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Annotation rule MF_01667
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General rule information [?]

Accession MF_01667
Dates 5-AUG-2008 (Created)
19-NOV-2019 (Last updated, Version 10)
Name 2_Hacid_dh_C_GhrB
Scope
Bacteria; Enterobacterales
Template P37666 (GHRB_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GHRB
Protein name
RecName: Full=Glyoxylate/hydroxypyruvate reductase B;
EC 1.1.1.79;
EC 1.1.1.81;
Gene name
ghrB

Comments [?]

Function Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
Catalytic activity RHEA:10992: glycolate + NADP(+) = glyoxylate + H(+) + NADPH
EC 1.1.1.79
RHEA:17905: (R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH
EC 1.1.1.81
RHEA:18657: (R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH
EC 1.1.1.81
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.

Keywords [?]


Gene Ontology [?]

GO:0016618; Molecular function: hydroxypyruvate reductase activity.
GO:0030267; Molecular function: glyoxylate reductase (NADP) activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1;
PS00670; D_2_HYDROXYACID_DH_2; 1;
PS00671; D_2_HYDROXYACID_DH_3; 1;
Pfam PF00389; 2-Hacid_dh; 1;
PF02826; 2-Hacid_dh_C; 1;

Features [?]

From: GHRB_ECOLI (P37666)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     237     237             R  
ACT_SITE     266     266             E  
ACT_SITE     285     285       Proton donor     H  

Additional information [?]

Size range 320-326 amino acids
Related rules None
Fusion None