HAMAP rule MF_01667
General rule information
[?]
Accession | MF_01667 |
Dates | 5-AUG-2008 (Created) 13-JAN-2021 (Last updated, Version 11) |
Name | 2_Hacid_dh_C_GhrB |
Scope | Bacteria; Enterobacterales |
Template | P37666 (GHRB_ECOLI) |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
Protein name |
|
Gene name |
|
Comments
[?]
Function | Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. |
Catalytic activity | RHEA:10992: glycolate + NADP(+) = glyoxylate + H(+) + NADPH
EC 1.1.1.79 |
RHEA:17905: (R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH
EC 1.1.1.81 |
|
RHEA:18657: (R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH
EC 1.1.1.81 |
|
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. |
Keywords
[?]
Gene Ontology
[?]
GO:0016618; Molecular function: hydroxypyruvate reductase activity.
GO:0030267; Molecular function: glyoxylate reductase (NADP+) activity.
GO:0005886; Cellular component: plasma membrane.
GO:0030267; Molecular function: glyoxylate reductase (NADP+) activity.
GO:0005886; Cellular component: plasma membrane.
Cross-references
[?]
PROSITE | PS00065; D_2_HYDROXYACID_DH_1; 1; |
PS00670; D_2_HYDROXYACID_DH_2; 1; | |
PS00671; D_2_HYDROXYACID_DH_3; 1; | |
Pfam | PF00389; 2-Hacid_dh; 1; |
PF02826; 2-Hacid_dh_C; 1; |
Features
[?]
From: GHRB_ECOLI (P37666) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 237 | 237 | R | |||||||||
ACT_SITE | 266 | 266 | E | |||||||||
ACT_SITE | 285 | 285 | Proton donor | H |
Additional information
[?]
Size range | 320-326 amino acids |
Related rules | None |
Fusion | None |