HAMAP rule MF_01667
General rule information
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| Accession | MF_01667 |
| Dates | 5-AUG-2008 (Created) 13-JAN-2021 (Last updated, Version 11) |
| Name | 2_Hacid_dh_C_GhrB |
| Scope | Bacteria; Enterobacterales |
| Template | P37666 (GHRB_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. |
| Catalytic activity | RHEA:10992: glycolate + NADP(+) = glyoxylate + H(+) + NADPH
EC 1.1.1.79 |
| RHEA:17905: (R)-glycerate + NAD(+) = 3-hydroxypyruvate + H(+) + NADH
EC 1.1.1.81 |
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| RHEA:18657: (R)-glycerate + NADP(+) = 3-hydroxypyruvate + H(+) + NADPH
EC 1.1.1.81 |
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| Subunit | Homodimer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. |
Keywords
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Gene Ontology
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GO:0016618; Molecular function: hydroxypyruvate reductase activity.
GO:0030267; Molecular function: glyoxylate reductase (NADP+) activity.
GO:0005886; Cellular component: plasma membrane.
GO:0030267; Molecular function: glyoxylate reductase (NADP+) activity.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| PROSITE | PS00065; D_2_HYDROXYACID_DH_1; 1; |
| PS00670; D_2_HYDROXYACID_DH_2; 1; | |
| PS00671; D_2_HYDROXYACID_DH_3; 1; | |
| Pfam | PF00389; 2-Hacid_dh; 1; |
| PF02826; 2-Hacid_dh_C; 1; |
Features
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| From: GHRB_ECOLI (P37666) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 237 | 237 | R | |||||||||
| ACT_SITE | 266 | 266 | E | |||||||||
| ACT_SITE | 285 | 285 | Proton donor | H | ||||||||
Additional information
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| Size range | 320-326 amino acids |
| Related rules | None |
| Fusion | None |