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HAMAP rule MF_01674

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General rule information [?]

Accession MF_01674
Dates 7-OCT-2008 (Created)
1-JUN-2023 (Last updated, Version 13)
Name Sep_tRNA_synth
Scope(s) Archaea
Template(s) Q59054 (SEPS_METJA); O30126 (SEPS_ARCFU); [ Recover all ]
Triggered by HAMAP; MF_01674 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SEPS
Protein name RecName: Full=O-phosphoserine--tRNA(Cys) ligase;
                 Short=O-phosphoserine--tRNA ligase;
AltName: Full=Non-canonical O-phosphoseryl-tRNA(Cys) synthetase;
AltName: Full=O-phosphoseryl-tRNA(Cys) synthetase;
Gene name Name=sepS;

Comments [?]

FUNCTIONCatalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
CATALYTIC ACTIVITY Reaction=ATP + O-phospho-L-serine + tRNA(Cys) = AMP + diphosphate + O- phospho-L-seryl-tRNA(Cys); Xref=Rhea:RHEA:25678, Rhea:RHEA-COMP:9661, Rhea:RHEA-COMP:9719, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57524, ChEBI:CHEBI:78442, ChEBI:CHEBI:78551, ChEBI:CHEBI:456215; EC=;
SUBUNITHomotetramer. Interacts with SepCysS.
SIMILARITYBelongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004812; Molecular function:aminoacyl-tRNA ligase activity
GO:0005524; Molecular function:ATP binding
GO:0043039; Biological process:tRNA aminoacylation

Cross-references [?]

Pfam PF01409; tRNA-synt_2d; 2;
NCBIfam TIGR00470; SepS; 1;

Features [?]

From: SEPS_ARCFU (O30126)
Key From To Description Tag Condition FTGroup
BINDING 186 188 /ligand="substrate" H-M-T
BINDING 231 233 /ligand="substrate" S-A-S
BINDING 273 274 /ligand="substrate" Y-Y
BINDING 325 325 /ligand="substrate" N

Additional information [?]

Size range 526-562 amino acids
Related rules None
Fusion Nter: None Cter: None

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