HAMAP rule MF_01674

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01674
Accession	MF_01674
Dates	7-OCT-2008 (Created) 3-SEP-2024 (Last updated, Version 14)
Name	Sep_tRNA_synth
Scope(s)	Archaea
Template(s)	Q59054 (SEPS_METJA); O30126 (SEPS_ARCFU); [ Recover all ]
Triggered by	HAMAP; MF_01674 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SEPS
Protein name	RecName: Full=O-phosphoserine--tRNA(Cys) ligase; Short=O-phosphoserine--tRNA ligase; EC=6.1.1.27; AltName: Full=Non-canonical O-phosphoseryl-tRNA(Cys) synthetase; AltName: Full=O-phosphoseryl-tRNA(Cys) synthetase; Short=SepRS;
Gene name	Name=sepS;

Comments [?]

FUNCTION	Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
CATALYTIC ACTIVITY	Reaction=tRNA(Cys) + O-phospho-L-serine + ATP = O-phospho-L-seryl- tRNA(Cys) + AMP + diphosphate; Xref=Rhea:RHEA:25678, Rhea:RHEA- COMP:9661, Rhea:RHEA-COMP:9719, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57524, ChEBI:CHEBI:78442, ChEBI:CHEBI:78551, ChEBI:CHEBI:456215; EC=6.1.1.27;
SUBUNIT	Homotetramer. Interacts with SepCysS.
SIMILARITY	Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004812; Molecular function:aminoacyl-tRNA ligase activity

GO:0005524; Molecular function:ATP binding

GO:0043039; Biological process:tRNA aminoacylation

Cross-references [?]

Features [?]

From: SEPS_ARCFU (O30126)

Key

From

Description

Tag

Condition

FTGroup

BINDING

186

188

/ligand="substrate"

H-M-T

BINDING

231

233

/ligand="substrate"

S-A-S

BINDING

273

274

/ligand="substrate"

Y-Y

BINDING

325

/ligand="substrate"

Additional information [?]