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HAMAP rule MF_01676

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General rule information [?]

Accession MF_01676
Dates 9-OCT-2008 (Created)
14-SEP-2023 (Last updated, Version 18)
Name AhpD
Scope(s) Bacteria
Template(s) P9WQB5 (AHPD_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_01676 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AHPD
Protein name RecName: Full=Alkyl hydroperoxide reductase AhpD;
AltName: Full=Alkylhydroperoxidase AhpD;
Gene name Name=ahpD;

Comments [?]

FUNCTIONAntioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
CATALYTIC ACTIVITY Reaction=a hydroperoxide + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl- carrier protein] = an alcohol + H2O + N(6)-[(R)-lipoyl]-L-lysyl- [lipoyl-carrier protein]; Xref=Rhea:RHEA:62636, Rhea:RHEA-COMP:10502, Rhea:RHEA-COMP:16355, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=;
case <OC:Actinomycetota>
end case
SIMILARITYBelongs to the AhpD family.

Keywords [?]

Gene Ontology [?]

GO:0008785; Molecular function:alkyl hydroperoxide reductase activity
GO:0016209; Molecular function:antioxidant activity

Cross-references [?]

Pfam PF02627; CMD; 1;
NCBIfam TIGR00777; AhpD; 1;
NCBIfam TIGR00778; AhpD_dom; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 130 130 /note="Proton donor" C
ACT_SITE 133 133 /note="Cysteine sulfenic acid (-SOH) intermediate" C
DISULFID 130 133 C-x*-C
DISULFID 133 133 /note="Interchain (with AhpC); in linked form" C

Additional information [?]

Size range 173-194 amino acids
Related rules None
Fusion Nter: None Cter: None

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