HAMAP rule MF_01676
General rule information
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Accession | MF_01676 |
Dates | 9-OCT-2008 (Created)
14-SEP-2023 (Last updated, Version 18) |
Name | AhpD |
Scope(s) |
Bacteria |
Template(s) | P9WQB5 (AHPD_MYCTU); [ Recover all ] |
Triggered by |
HAMAP; MF_01676 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | AHPD |
Protein name | RecName: Full=Alkyl hydroperoxide reductase AhpD; EC=1.11.1.28; AltName: Full=Alkylhydroperoxidase AhpD; |
Gene name | Name=ahpD; |
Comments
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FUNCTION | Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. |
CATALYTIC ACTIVITY | Reaction=a hydroperoxide + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl- carrier protein] = an alcohol + H2O + N(6)-[(R)-lipoyl]-L-lysyl- [lipoyl-carrier protein]; Xref=Rhea:RHEA:62636, Rhea:RHEA-COMP:10502, Rhea:RHEA-COMP:16355, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=1.11.1.28; |
case <OC:Actinomycetota> | |
SUBUNIT | Homotrimer. |
end case | |
SIMILARITY | Belongs to the AhpD family. |
Keywords
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Antioxidant | |
case <FT:3> or <FT:4> | |
Disulfide bond | |
end case | |
Oxidoreductase | |
Peroxidase | |
Redox-active center |
Gene Ontology
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GO:0008785; Molecular function:alkyl hydroperoxide reductase activity |
GO:0016209; Molecular function:antioxidant activity |
Cross-references
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Features
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From: AHPD_MYCTU (P9WQB5) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 130 | 130 | /note="Proton donor" | C | ||||||||
ACT_SITE | 133 | 133 | /note="Cysteine sulfenic acid (-SOH) intermediate" | C | ||||||||
DISULFID | 130 | 133 | C-x*-C | |||||||||
DISULFID | 133 | 133 | /note="Interchain (with AhpC); in linked form" | C |
Additional information
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Size range | 173-194 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |