HAMAP rule MF_01676

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01676
Accession	MF_01676
Dates	09-OCT-2008 (Created) 06-FEB-2025 (Last updated, Version 21)
Name	AhpD
Scope(s)	Bacteria
Template(s)	P9WQB5; [ Recover all ]
Triggered by	HAMAP; MF_01676 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	AHPD
Protein name	RecName: Full=Alkyl hydroperoxide reductase AhpD; EC=1.11.1.28; AltName: Full=Alkylhydroperoxidase AhpD;
Gene name	Name=ahpD;

Comments [?]

FUNCTION	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.
CATALYTIC ACTIVITY	Reaction=N(6)-[(R)-dihydrolipoyl]-L-lysyl-[lipoyl-carrier protein] + a hydroperoxide = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + an alcohol + H2O; Xref=Rhea:RHEA:62636, Rhea:RHEA-COMP:10502, Rhea:RHEA-COMP:16355, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924, ChEBI:CHEBI:83099, ChEBI:CHEBI:83100; EC=1.11.1.28;
case <OC:Actinomycetota>
SUBUNIT	Homotrimer.
end case
SIMILARITY	Belongs to the AhpD family.

Keywords [?]

Gene Ontology [?]

GO:0016209; Molecular function:antioxidant activity

Cross-references [?]

Features [?]

From: AHPD_MYCTU (P9WQB5)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

130

/note="Proton donor"

ACT_SITE

133

/note="Cysteine sulfenic acid (-SOH) intermediate"

DISULFID

130

133

C-x*-C

DISULFID

133

/note="Interchain (with AhpC); in linked form"

Additional information [?]