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HAMAP rule MF_01678

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General rule information [?]

Accession MF_01678
Dates 21-OCT-2008 (Created)
1-JUN-2023 (Last updated, Version 25)
Name Salvage_MtnA
Scope(s) Bacteria
Template(s) O31662 (MTNA_BACSU); [ Recover all ]
Triggered by
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01678 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MTNA
case <OC:Archaea>
Protein name RecName: Full=Putative methylthioribose-1-phosphate isomerase;
                 Short=MTR-1-P isomerase;
AltName: Full=MTNA-like protein;
AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;
Protein name RecName: Full=Methylthioribose-1-phosphate isomerase;
                 Short=MTR-1-P isomerase;
AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;
end case
case <OC:Bacteria>
Gene name Name=mtnA;
end case

Comments [?]

FUNCTIONCatalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
CATALYTIC ACTIVITY Reaction=S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio- D-ribulose 1-phosphate; Xref=Rhea:RHEA:19989, ChEBI:CHEBI:58533, ChEBI:CHEBI:58548; EC=;
case <OC:Bacteria>
PATHWAYAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.
end case
case <OC:Bacillaceae>
end case
SIMILARITYBelongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0046523; Molecular function:S-methyl-5-thioribose-1-phosphate isomerase activity
GO:0019284; Biological process:L-methionine salvage from S-adenosylmethionine

Cross-references [?]

Pfam PF01008; IF-2B; 1;
NCBIfam TIGR00524; EIF-2B_rel; 1;
NCBIfam TIGR00512; Salvage_mtnA; 1;

Features [?]

From: MTNA_BACSU (O31662)
Key From To Description Tag Condition FTGroup
BINDING 51 53 /ligand="substrate"
BINDING 250 251 /ligand="substrate"
ACT_SITE 240 240 /note="Proton donor" D
BINDING 94 94 /ligand="substrate" R
BINDING 199 199 /ligand="substrate" Q
SITE 160 160 /note="Transition state stabilizer" [CS]

Additional information [?]

Size range 311-552 amino acids
Related rules MF_02229
Fusion Nter: <Thioesterase> Cter: None

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