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HAMAP rule MF_01678

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General rule information [?]

Accession MF_01678
Dates 21-OCT-2008 (Created)
14-MAY-2022 (Last updated, Version 24)
Name Salvage_MtnA
Scope
Bacteria
Archaea
Template O31662 (MTNA_BACSU)
case <OC:Bacteria> or <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MTNA
case <OC:Archaea>
Protein name
RecName: Full=Putative methylthioribose-1-phosphate isomerase;
Short=M1Pi;
Short=MTR-1-P isomerase;
EC 5.3.1.23;
AltName: Full=MTNA-like protein;
Short=aMTNA;
AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;
else
Protein name
RecName: Full=Methylthioribose-1-phosphate isomerase;
Short=M1Pi;
Short=MTR-1-P isomerase;
EC 5.3.1.23;
AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase;
end case
case <OC:Bacteria>
Gene name
mtnA
end case

Comments [?]

Function Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Catalytic activity RHEA:19989: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
EC 5.3.1.23
case <OC:Bacteria>
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.
end case
case <OC:Bacillaceae>
Subunit Homodimer.
end case
Similarity Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.

Keywords [?]

Amino-acid biosynthesis
Isomerase
Methionine biosynthesis

Gene Ontology [?]

GO:0046523; Molecular function: S-methyl-5-thioribose-1-phosphate isomerase activity.
GO:0019284; Biological process: L-methionine salvage from S-adenosylmethionine.

Cross-references [?]

Pfam PF01008; IF-2B; 1;
TIGRFAMs TIGR00524; EIF-2B_rel; 1;
TIGR00512; Salvage_mtnA; 1;

Features [?]

From: MTNA_BACSU (O31662)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     51     53       /ligand="substrate        
BINDING     250     251       /ligand="substrate        
ACT_SITE     240     240       Proton donor     D  
BINDING     94     94       /ligand="substrate     R  
BINDING     199     199       /ligand="substrate     Q  
SITE     160     160       Transition state stabilizer     [CS]  

Additional information [?]

Size range 311-552 amino acids
Related rules MF_02229 (DRDI supersedes the current rule)
Fusion Nter: <Thioesterase>; Cter: None


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