HAMAP rule MF_01678
General rule information
[?]
| Accession | MF_01678 |
| Dates | 21-OCT-2008 (Created)
30-APR-2024 (Last updated, Version 26) |
| Name | Salvage_MtnA |
| Scope(s) |
Bacteria Archaea |
| Template(s) | O31662 (MTNA_BACSU); [ Recover all ] |
| Triggered by |
case c? <OC:Bacteria> or <OC:Archaea>
HAMAP; MF_01678 (Get profile general information and statistics) end case
|
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | MTNA |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Putative methylthioribose-1-phosphate isomerase; Short=M1Pi; Short=MTR-1-P isomerase; EC=5.3.1.23; AltName: Full=MTNA-like protein; Short=aMTNA; AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase; |
| else | |
| Protein name | RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi; Short=MTR-1-P isomerase; EC=5.3.1.23; AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase; |
| end case | |
| case <OC:Bacteria> | |
| Gene name | Name=mtnA; |
| end case | |
Comments
[?]
| FUNCTION | Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). |
| CATALYTIC ACTIVITY | Reaction=S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio- D-ribulose 1-phosphate; Xref=Rhea:RHEA:19989, ChEBI:CHEBI:58533, ChEBI:CHEBI:58548; EC=5.3.1.23; |
| case <OC:Bacteria> | |
| PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. |
| end case | |
| case <OC:Bacillaceae> | |
| SUBUNIT | Homodimer. |
| end case | |
| SIMILARITY | Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0046523; Molecular function:S-methyl-5-thioribose-1-phosphate isomerase activity |
| GO:0019509; Biological process:L-methionine salvage from methylthioadenosine |
Cross-references
[?]
Features
[?]
| From: MTNA_BACSU (O31662) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 51 | 53 | /ligand="substrate" | |||||||||
| BINDING | 250 | 251 | /ligand="substrate" | |||||||||
| ACT_SITE | 240 | 240 | /note="Proton donor" | D | ||||||||
| BINDING | 94 | 94 | /ligand="substrate" | R | ||||||||
| BINDING | 199 | 199 | /ligand="substrate" | Q | ||||||||
| SITE | 160 | 160 | /note="Transition state stabilizer" | [CS] | ||||||||
Additional information
[?]
| Size range | 311-552 amino acids |
| Related rules |
MF_02229 |
| Fusion | Nter: <Thioesterase> Cter: None |