HAMAP rule MF_01683
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01683 |
| Accession | MF_01683 |
| Dates | 19-NOV-2008 (Created)
19-SEP-2024 (Last updated, Version 21) |
| Name | Salvage_MtnK |
| Scope(s) |
Bacteria |
| Template(s) | O31663; Q9F0P1; [ Recover all ] |
| Triggered by |
HAMAP; MF_01683 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MTNK |
| Protein name | RecName: Full=Methylthioribose kinase; Short=MTR kinase; EC=2.7.1.100; |
| Gene name | Name=mtnK; |
Comments
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| FUNCTION | Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. |
| CATALYTIC ACTIVITY | Reaction=5-(methylsulfanyl)-D-ribose + ATP = 5-(methylsulfanyl)-alpha- D-ribose 1-phosphate + ADP + H(+); Xref=Rhea:RHEA:22312, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58533, ChEBI:CHEBI:78440, ChEBI:CHEBI:456216; EC=2.7.1.100; |
| PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'- thioadenosine (hydrolase route): step 2/2. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the methylthioribose kinase family. |
Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0046522; Molecular function:S-methyl-5-thioribose kinase activity |
| GO:0019509; Biological process:L-methionine salvage from methylthioadenosine |
Cross-references
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| Pfam | PF01636; APH; 1; |
| PIRSF | PIRSF031134; MTRK; 1; |
| NCBIfam | TIGR01767; MTRK; 1; |
Features
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| From: MTNK_BACSU (O31663) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 115 | 117 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
E-D-L | ||||||||
| BINDING | 250 | 252 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D-[AP]-E | ||||||||
| BINDING | 44 | 44 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
N | ||||||||
| BINDING | 61 | 61 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 233 | 233 | /ligand="substrate" | D | ||||||||
| BINDING | 340 | 340 | /ligand="substrate" | R | ||||||||
Additional information
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| Size range | 389-407 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |