HAMAP rule MF_01686

General rule information [?]

Accession	MF_01686
Dates	30-JAN-2009 (Created) 19-NOV-2019 (Last updated, Version 6)

Name	Thymidy_synth_arch

Scope

Archaea

Template

P80305 (TYSY_METTM)

Triggered by

HAMAP; MF_01686 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

TYSY

Protein name

RecName:		Full=Putative thymidylate synthase;
		Short=TS;
		Short=TSase;
		EC 2.1.1.-;

Gene name

thyA

Comments [?]

Function	May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
Pathway	Pyrimidine metabolism; dTTP biosynthesis.
Subunit	Monomer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.

Keywords [?]

Cytoplasm
Methyltransferase
Nucleotide biosynthesis
Transferase

Gene Ontology [?]

GO:0004799; Molecular function: thymidylate synthase activity.
GO:0006231; Biological process: dTMP biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS00091; THYMIDYLATE_SYNTHASE; 1;
Pfam	PF00303; Thymidylat_synt; 1;
PRINTS	PR00108; THYMDSNTHASE; 1;
TIGRFAMs	TIGR03283; Thy_syn_methano; 1;

Features [?]

From: TYSY_METTM (P80305)

Key From To Description Tag Condition FTGroup

ACT_SITE 146 146 C

Additional information [?]

Size range	209-223 amino acids
Related rules	MF_00008 (TYSY)
Fusion	None
Comments	Bacterial ThyA belong to a separate family (MF_00008).

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