HAMAP rule MF_01686
General rule information
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| Accession | MF_01686 |
| Dates | 30-JAN-2009 (Created)
31-JAN-2024 (Last updated, Version 8) |
| Name | Thymidy_synth_arch |
| Scope(s) |
Archaea |
| Template(s) | P80305 (TYSY_METTM); [ Recover all ] |
| Triggered by |
HAMAP; MF_01686 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TYSY |
| Protein name | RecName: Full=Putative thymidylate synthase; Short=TS; Short=TSase; EC=2.1.1.-; |
| Gene name | Name=thyA; |
Comments
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| FUNCTION | May catalyze the biosynthesis of dTMP using an unknown cosubstrate. |
| PATHWAY | Pyrimidine metabolism; dTTP biosynthesis. |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. |
Keywords
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Gene Ontology
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| GO:0004799; Molecular function:thymidylate synthase activity |
| GO:0006231; Biological process:dTMP biosynthetic process |
| GO:0006235; Biological process:dTTP biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS00091; THYMIDYLATE_SYNTHASE; 1; |
| Pfam | PF00303; Thymidylat_synt; 1; |
| PRINTS | PR00108; THYMDSNTHASE; 1; |
| NCBIfam | TIGR03283; Thy_syn_methano; 1; |
Features
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| From: TYSY_METTM (P80305) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 146 | 146 | C | |||||||||
Additional information
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| Size range | 209-223 amino acids |
| Related rules |
MF_00008 |
| Fusion | Nter: None Cter: None |
| Comments | Bacterial ThyA belong to a separate family (MF_00008). |