HAMAP rule MF_01686
General rule information
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Accession | MF_01686 |
Dates | 30-JAN-2009 (Created)
1-JUN-2023 (Last updated, Version 7) |
Name | Thymidy_synth_arch |
Scope(s) |
Archaea |
Template(s) | P80305 (TYSY_METTM); [ Recover all ] |
Triggered by |
HAMAP; MF_01686 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TYSY |
Protein name | RecName: Full=Putative thymidylate synthase; Short=TS; Short=TSase; EC=2.1.1.-; |
Gene name | Name=thyA; |
Comments
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FUNCTION | May catalyze the biosynthesis of dTMP using an unknown cosubstrate. |
PATHWAY | Pyrimidine metabolism; dTTP biosynthesis. |
SUBUNIT | Monomer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily. |
Keywords
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Gene Ontology
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GO:0004799; Molecular function:thymidylate synthase activity |
GO:0006231; Biological process:dTMP biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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PROSITE | PS00091; THYMIDYLATE_SYNTHASE; 1; |
Pfam | PF00303; Thymidylat_synt; 1; |
PRINTS | PR00108; THYMDSNTHASE; 1; |
NCBIfam | TIGR03283; Thy_syn_methano; 1; |
Features
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From: TYSY_METTM (P80305) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 146 | 146 | C |
Additional information
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Size range | 209-223 amino acids |
Related rules |
MF_00008 |
Fusion | Nter: None Cter: None |
Comments | Bacterial ThyA belong to a separate family (MF_00008). |