HAMAP rule MF_01688
General rule information
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Accession | MF_01688 |
Dates | 8-APR-2009 (Created) 1-JUN-2023 (Last updated, Version 19) |
Name | Biphenyl_BphD |
Scope | Bacteria; Pseudomonadota |
Template | P47229 (BPHD_PARXL) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD). |
Catalytic activity | RHEA:17161: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)
EC 3.7.1.8 |
Pathway | Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4. |
Subunit | Homodimer. |
Similarity | Belongs to the AB hydrolase superfamily. BphD family. |
Keywords
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Gene Ontology
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GO:0018771; Molecular function: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity.
GO:0019439; Biological process: aromatic compound catabolic process.
GO:0019439; Biological process: aromatic compound catabolic process.
Cross-references
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Features
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From: BPHD_PARXL (P47229) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 42 | 43 | /ligand="substrate | G-G | ||||||||
ACT_SITE | 112 | 112 | S | |||||||||
ACT_SITE | 265 | 265 | Proton acceptor | H | ||||||||
BINDING | 51 | 51 | /ligand="substrate | N | ||||||||
BINDING | 111 | 111 | /ligand="substrate | [KN] | ||||||||
BINDING | 180 | 180 | /ligand="substrate | [ST] | ||||||||
BINDING | 190 | 190 | /ligand="substrate | R | ||||||||
BINDING | 266 | 266 | /ligand="substrate | W | ||||||||
SITE | 112 | 112 | Transition state stabilizer | S |
Additional information
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Size range | 286-286 amino acids |
Related rules | None |
Fusion | None |