HAMAP rule MF_01688

General rule information [?]

Accession	MF_01688
Dates	8-APR-2009 (Created) 26-JAN-2023 (Last updated, Version 18)

Name	Biphenyl_BphD

Scope

Bacteria; Pseudomonadota

Template

P47229 (BPHD_PARXL)

Triggered by

HAMAP; MF_01688 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

BPHD

Protein name

RecName:		Full=2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase;
		Short=HOPDA hydrolase;
		EC 3.7.1.8;
AltName:		Full=2,6-dioxo-6-phenylhexa-3-enoate hydrolase;

Gene name

bphD

Comments [?]

Function	Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD).
Catalytic activity	RHEA:17161: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+) EC 3.7.1.8
Pathway	Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4.
Subunit	Homodimer.
Similarity	Belongs to the AB hydrolase superfamily. BphD family.

Keywords [?]

Aromatic hydrocarbons catabolism
Hydrolase

Gene Ontology [?]

GO:0018771; Molecular function: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Pfam	PF00561; Abhydrolase_1; 1;
TIGRFAMs	TIGR03343; Biphenyl_bphD; 1;

Features [?]

From: BPHD_PARXL (P47229)

Key From To Description Tag Condition FTGroup

BINDING 42 43 /ligand="substrate G-G

ACT_SITE 112 112 S

ACT_SITE 265 265 Proton acceptor H

BINDING 51 51 /ligand="substrate N

BINDING 111 111 /ligand="substrate [KN]

BINDING 180 180 /ligand="substrate [ST]

BINDING 190 190 /ligand="substrate R

BINDING 266 266 /ligand="substrate W

SITE 112 112 Transition state stabilizer S

Additional information [?]

Size range	286-286 amino acids
Related rules	None
Fusion	None

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