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HAMAP rule MF_01688

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General rule information [?]

Accession MF_01688
Dates 8-APR-2009 (Created)
1-JUN-2023 (Last updated, Version 19)
Name Biphenyl_BphD
Scope(s) Bacteria
Template(s) P47229 (BPHD_PARXL); [ Recover all ]
Triggered by HAMAP; MF_01688 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BPHD
Protein name RecName: Full=2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase;
                 Short=HOPDA hydrolase;
AltName: Full=2,6-dioxo-6-phenylhexa-3-enoate hydrolase;
Gene name Name=bphD;

Comments [?]

FUNCTIONCatalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo- 6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2- hydroxy-2,4-pentadienoic acid (HPD).
CATALYTIC ACTIVITY Reaction=2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+); Xref=Rhea:RHEA:17161, ChEBI:CHEBI:11641, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:64675; EC=;
PATHWAYXenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4- pentadienoate and benzoate from biphenyl: step 4/4.
SIMILARITYBelongs to the AB hydrolase superfamily. BphD family.

Keywords [?]

Gene Ontology [?]

GO:0018771; Molecular function:2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity
GO:0019439; Biological process:aromatic compound catabolic process

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;
NCBIfam TIGR03343; Biphenyl_bphD; 1;

Features [?]

From: BPHD_PARXL (P47229)
Key From To Description Tag Condition FTGroup
BINDING 42 43 /ligand="substrate" G-G
ACT_SITE 112 112 S
ACT_SITE 265 265 /note="Proton acceptor" H
BINDING 51 51 /ligand="substrate" N
BINDING 111 111 /ligand="substrate" [KN]
BINDING 180 180 /ligand="substrate" [ST]
BINDING 190 190 /ligand="substrate" R
BINDING 266 266 /ligand="substrate" W
SITE 112 112 /note="Transition state stabilizer" S

Additional information [?]

Size range 286-286 amino acids
Related rules None
Fusion Nter: None Cter: None

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