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HAMAP rule MF_01688

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General rule information [?]

Accession MF_01688
Dates 8-APR-2009 (Created)
1-JUN-2023 (Last updated, Version 19)
Name Biphenyl_BphD
Bacteria; Pseudomonadota
Template P47229 (BPHD_PARXL)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase;
Short=HOPDA hydrolase;
AltName: Full=2,6-dioxo-6-phenylhexa-3-enoate hydrolase;
Gene name

Comments [?]

Function Catalyzes an unusual C-C bond hydrolysis of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) to produce benzoic acid and 2-hydroxy-2,4-pentadienoic acid (HPD).
Catalytic activity RHEA:17161: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)
Pathway Xenobiotic degradation; biphenyl degradation; 2-hydroxy-2,4-pentadienoate and benzoate from biphenyl: step 4/4.
Subunit Homodimer.
Similarity Belongs to the AB hydrolase superfamily. BphD family.

Keywords [?]

Gene Ontology [?]

GO:0018771; Molecular function: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;
NCBIfam TIGR03343; Biphenyl_bphD; 1;

Features [?]

From: BPHD_PARXL (P47229)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     42     43       /ligand="substrate     G-G  
ACT_SITE     112     112             S  
ACT_SITE     265     265       Proton acceptor     H  
BINDING     51     51       /ligand="substrate     N  
BINDING     111     111       /ligand="substrate     [KN]  
BINDING     180     180       /ligand="substrate     [ST]  
BINDING     190     190       /ligand="substrate     R  
BINDING     266     266       /ligand="substrate     W  
SITE     112     112       Transition state stabilizer     S  

Additional information [?]

Size range 286-286 amino acids
Related rules None
Fusion None