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Annotation rule MF_01697
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General rule information [?]

Accession MF_01697
Dates 20-SEP-2010 (Created)
19-NOV-2019 (Last updated, Version 9)
Name MshC
Scope
Bacteria; Actinobacteria
Templates A0QZY0 (MSHC_MYCS2); P9WJM9 (MSHC_MYCTU): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MSHC
Protein name
RecName: Full=L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase;
Short=L-Cys:GlcN-Ins ligase;
EC 6.3.1.13;
AltName: Full=Mycothiol ligase;
Short=MSH ligase;
Gene name
mshC

Comments [?]

Function Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
Catalytic activity RHEA:26176: 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + ATP + L-cysteine = 1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + H(+)
EC 6.3.1.13
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
Subunit Monomer.
Similarity Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008270; Molecular function: zinc ion binding.
GO:0035446; Molecular function: cysteine-glucosaminylinositol ligase activity.
GO:0010125; Biological process: mycothiol biosynthetic process.

Cross-references [?]

Pfam PF01406; tRNA-synt_1e; 1;
PRINTS PR00983; TRNASYNTHCYS; 1;
TIGRFAMs TIGR03447; Mycothiol_MshC; 1;

Features [?]

From: MSHC_MYCS2 (A0QZY0)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     43     46       Cysteinyl adenylate binding     C-G-I-T  
REGION     81     83       Cysteinyl adenylate binding     N-x-T  
REGION     249     251       Cysteinyl adenylate binding     G-x-D  
MOTIF     45     55       'HIGH' region     I-T-P-Y-D-[AS]-[AT]-H-[ILM]-G-H  
MOTIF     187     192       'ERGGDP' region     [EDQ]-[HR]-G-G-D-P  
MOTIF     289     293       'KMSKS' region     K-M-S-K-S  
METAL     43     43       Zinc     C  
METAL     231     231       Zinc     C  
METAL     256     256       Zinc     H  
BINDING     58     58       Cysteinyl adenylate     [ST]  
BINDING     227     227       Cysteinyl adenylate     W  
BINDING     283     283       Cysteinyl adenylate; via amide nitrogen and carbonyl oxygen     [LIV]  

Additional information [?]

Size range 384-520 amino acids
Related rules None
Fusion None