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Annotation rule MF_01703 |
General rule information
[?]
Accession |
MF_01703 |
Dates |
11-OCT-2004 (Created) 8-SEP-2020 (Last updated, Version 20) |
Scope |
Bacteria; Proteobacteria |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=ATP-dependent lipid A-core flippase;
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EC 7.5.2.6;
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AltName:
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Full=Lipid A export ATP-binding/permease protein MsbA;
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Function |
Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. |
Catalytic activity |
Reaction=ATP + H(2)O + lipid A-core oligosaccharide(Side 1) = ADP + phosphate + lipid A-core oligosaccharide(Side 2).; EC=7.5.2.6; |
Subunit |
Homodimer. |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
end case
Domain |
In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused. |
Similarity |
Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0006869; Biological process: lipid transport.
GO:0034040; Molecular function: ATPase-coupled lipid transmembrane transporter activity.
case <OC:Bacteria>
end case
General |
Transmembrane; -; 5-6; trigger=yes; |
Additional information
[?]
Size range |
572-675 amino acids |
Related rules |
PRU01700 |
Fusion |
None |