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Annotation rule MF_01703
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General rule information [?]

Accession MF_01703
Dates 11-OCT-2004 (Created)
8-SEP-2020 (Last updated, Version 20)
Name ABC_ATPase_TM_MsbA
Scope
Bacteria; Proteobacteria
Template P60752 (MSBA_ECOLI)
Triggered by PROSITE; PS51239

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MSBA
Protein name
RecName: Full=ATP-dependent lipid A-core flippase;
EC 7.5.2.6;
AltName: Full=Lipid A export ATP-binding/permease protein MsbA;
Gene name
msbA

Comments [?]

Function Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Catalytic activity Reaction=ATP + H(2)O + lipid A-core oligosaccharide(Side 1) = ADP + phosphate + lipid A-core oligosaccharide(Side 2).; EC=7.5.2.6;
Subunit Homodimer.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Domain In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.
Similarity Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.

Keywords [?]

ATP-binding
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Translocase
Lipid transport
Membrane
Nucleotide-binding
Transmembrane
Transmembrane helix
Transport

Gene Ontology [?]

GO:0006869; Biological process: lipid transport.
GO:0034040; Molecular function: ATPase-coupled lipid transmembrane transporter activity.
case <OC:Bacteria>
GO:0005886; Cellular component: plasma membrane.
end case

Cross-references [?]

Pfam PF00005; ABC_tran; 1;
PF00664; ABC_membrane; 1;
TIGRFAMs TIGR02203; MsbA_lipidA; 1;
PROSITE PS50929; ABC_TM1F; 1; trigger=PRU00441;
PS00211; ABC_TRANSPORTER_1; 1;
PS50893; ABC_TRANSPORTER_2; 1; trigger=PRU00434;

Computed features [?]

General Transmembrane; -; 5-6; trigger=yes;

Additional information [?]

Size range 572-675 amino acids
Related rules PRU01700
Fusion None


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