HAMAP rule MF_01710
General rule information
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| Accession | MF_01710 |
| Dates | 11-OCT-2004 (Created)
1-MAR-2024 (Last updated, Version 42) |
| Name | ABC_ATPase_CbiO_EcfA |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q05596 (CBIO_SALTY); O68106 (CBIO_RHOCB); A2RI01 (ECFA1_LACLM); Q03ZL6 (ECFA1_LEUMM); Q035B2 (ECFA1_LACP3); Q9X1Z1 (ECFA1_THEMA); Q9WY65 (ECFA2_THEMA); Q5M243 (ECFA1_STRT2); Q5M244 (ECFA2_STRT2); [ Recover all ] |
| Triggered by |
PROSITE; PS51246 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| case <OC:Pseudomonadota> | |
| Identifier | CBIO |
| Protein name | RecName: Full=Cobalt import ATP-binding protein CbiO; EC=7.-.-.-; AltName: Full=Energy-coupling factor transporter ATP-binding protein CbiO; Short=ECF transporter A component CbiO; |
| Gene name | Name=cbiO; |
| else | |
| Identifier | ECFA |
| Protein name | RecName: Full=Energy-coupling factor transporter ATP-binding protein EcfA; Short=ECF transporter A component EcfA; EC=7.-.-.-; |
| Gene name | Name=ecfA; |
| end case | |
Comments
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| case <OC:Pseudomonadota> | |
| FUNCTION | Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. Presumably responsible for energy coupling to the transport system. |
| PATHWAY | Cofactor biosynthesis; adenosylcobalamin biosynthesis. |
| SUBUNIT | Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry. |
| else | |
| FUNCTION | ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. |
| SUBUNIT | Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component). |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
| end case | |
| case <OC:Pseudomonadota> | |
| SIMILARITY | Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family. |
| else | |
| SIMILARITY | Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family. |
| end case | |
Keywords
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| ATP-binding | |
| Nucleotide-binding | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Membrane | |
| Transport | |
| case <OC:Pseudomonadota> | |
| Cobalt | |
| Cobalt transport | |
| Cobalamin biosynthesis | |
| Ion transport | |
| end case | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
Gene Ontology
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| case <OCellular component:Pseudomonadota> | |
| GO:0006824; Biological process:cobalt ion transport | |
| GO:0009236; Biological process:cobalamin biosynthetic process | |
| GO:0015087; Molecular function:cobalt ion transmembrane transporter activity | |
| end case | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
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| Pfam | PF00005; ABC_tran; 1; |
| NCBIfam | TIGR01166; CbiO; 1; |
| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
| PROSITE | PS50893; ABC_TRANSPORTER_2; 1; |
Features
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| # Fix case/else syntax |
Additional information
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| Size range | 200-591 amino acids |
| Related rules |
PRU01700 |
| Fusion | Nter: None Cter: None |
| Comments | In Pseudomonadota is part of a dedicated cobalt transporter; RHOCB is experimentally a member of this family but does not fit the PROSITE profile. In Bacillota (and probably other bacteria and archaea) this is an ABC subunit of an energy-coupling transporter that imports more than 1 substrate. See: PubMed=18931129; DOI=10.1128/JB.01208-08; Rodionov D.A., Hebbeln P., Eudes A., ter Beek J., Rodionova I.A., Erkens G.B., Slotboom D.J., Gelfand M.S., Osterman A.L., Hanson A.D., Eitinger T.; "A novel class of modular transporters for vitamins in prokaryotes."; J. Bacteriol. 191:42-51(2009). The subunit composition has been determined to be 2S:2T:A1:A2 PMID:23359690. |