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Annotation rule MF_01710 |
General rule information
[?]
Accession |
MF_01710 |
Dates |
11-OCT-2004 (Created) 19-NOV-2019 (Last updated, Version 28) |
Name |
ABC_ATPase_CbiO_EcfA |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Proteobacteria>
Protein name |
RecName:
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Full=Cobalt import ATP-binding protein CbiO;
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EC 7.-.-.-;
|
AltName:
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Full=Energy-coupling factor transporter ATP-binding protein CbiO;
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Short=ECF transporter A component CbiO;
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|
else
Protein name |
RecName:
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Full=Energy-coupling factor transporter ATP-binding protein EcfA;
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|
Short=ECF transporter A component EcfA;
|
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EC 7.-.-.-;
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|
end case
case <OC:Proteobacteria>
Function |
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. Presumably responsible for energy coupling to the transport system. |
Pathway |
Cofactor biosynthesis; adenosylcobalamin biosynthesis. |
Subunit |
Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry. |
else
Function |
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. |
Subunit |
Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component). |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Peripheral membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Peripheral membrane protein. |
end case
case <OC:Proteobacteria>
Similarity |
Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family. |
else
Similarity |
Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family. |
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case
case <OC:Proteobacteria>
end case
case <OC:Proteobacteria>
GO:0006824; Biological process: cobalt ion transport.
GO:0015087; Molecular function: cobalt ion transmembrane transporter activity.
end case
Additional information
[?]
Size range |
200-591 amino acids |
Related rules |
PRU01700 |
Fusion |
None |
Comments |
In Proteobacteria is part of a dedicated cobalt transporter; RHOCB is experimentally a member of this family but does not fit the PROSITE profile. In Firmicutes (and probably other bacteria and archaea) this is an ABC subunit of an energy-coupling transporter that imports more than 1 substrate. See: PubMed=18931129; DOI=10.1128/JB.01208-08; Rodionov D.A., Hebbeln P., Eudes A., ter Beek J., Rodionova I.A., Erkens G.B., Slotboom D.J., Gelfand M.S., Osterman A.L., Hanson A.D., Eitinger T.; "A novel class of modular transporters for vitamins in prokaryotes."; J. Bacteriol. 191:42-51(2009). The subunit composition has been determined to be 2S:2T:A1:A2 PMID:23359690. |