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HAMAP rule MF_01710

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General rule information [?]

Accession MF_01710
Dates 11-OCT-2004 (Created)
1-MAR-2024 (Last updated, Version 42)
Name ABC_ATPase_CbiO_EcfA
Scope(s) Bacteria
Template(s) Q05596 (CBIO_SALTY); O68106 (CBIO_RHOCB); A2RI01 (ECFA1_LACLM); Q03ZL6 (ECFA1_LEUMM); Q035B2 (ECFA1_LACP3); Q9X1Z1 (ECFA1_THEMA); Q9WY65 (ECFA2_THEMA); Q5M243 (ECFA1_STRT2); Q5M244 (ECFA2_STRT2); [ Recover all ]
Triggered by PROSITE; PS51246 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Pseudomonadota>
Identifier CBIO
Protein name RecName: Full=Cobalt import ATP-binding protein CbiO;
AltName: Full=Energy-coupling factor transporter ATP-binding protein CbiO;
                 Short=ECF transporter A component CbiO;
Gene name Name=cbiO;
Identifier ECFA
Protein name RecName: Full=Energy-coupling factor transporter ATP-binding protein EcfA;
                 Short=ECF transporter A component EcfA;
Gene name Name=ecfA;
end case

Comments [?]

case <OC:Pseudomonadota>
FUNCTIONPart of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. Presumably responsible for energy coupling to the transport system.
PATHWAYCofactor biosynthesis; adenosylcobalamin biosynthesis.
SUBUNITForms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
FUNCTIONATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
SUBUNITForms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Peripheral membrane protein.
end case
case <OC:Pseudomonadota>
SIMILARITYBelongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family.
SIMILARITYBelongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
end case

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
case <OC:Pseudomonadota>
Cobalt transport
Cobalamin biosynthesis
Ion transport
end case
<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>

Gene Ontology [?]

case <OCellular component:Pseudomonadota>
GO:0006824; Biological process:cobalt ion transport
GO:0009236; Biological process:cobalamin biosynthetic process
GO:0015087; Molecular function:cobalt ion transmembrane transporter activity
end case
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00005; ABC_tran; 1;
NCBIfam TIGR01166; CbiO; 1;

Features [?]

# Fix case/else syntax

Additional information [?]

Size range 200-591 amino acids
Related rules PRU01700
Fusion Nter: None Cter: None
Comments In Pseudomonadota is part of a dedicated cobalt transporter; RHOCB is experimentally a member of this family but does not fit the PROSITE profile. In Bacillota (and probably other bacteria and archaea) this is an ABC subunit of an energy-coupling transporter that imports more than 1 substrate. See: PubMed=18931129; DOI=10.1128/JB.01208-08; Rodionov D.A., Hebbeln P., Eudes A., ter Beek J., Rodionova I.A., Erkens G.B., Slotboom D.J., Gelfand M.S., Osterman A.L., Hanson A.D., Eitinger T.; "A novel class of modular transporters for vitamins in prokaryotes."; J. Bacteriol. 191:42-51(2009). The subunit composition has been determined to be 2S:2T:A1:A2 PMID:23359690.

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