HAMAP rule MF_01710
General rule information
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Accession | MF_01710 |
Dates | 11-OCT-2004 (Created) 1-JUN-2023 (Last updated, Version 41) |
Name | ABC_ATPase_CbiO_EcfA |
Scope | Bacteria
Archaea |
Templates | Q05596 (CBIO_SALTY); O68106 (CBIO_RHOCB); A2RI01 (ECFA1_LACLM); Q03ZL6 (ECFA1_LEUMM); Q035B2 (ECFA1_LACP3); Q9X1Z1 (ECFA1_THEMA); Q9WY65 (ECFA2_THEMA); Q5M243 (ECFA1_STRT2); Q5M244 (ECFA2_STRT2): [Recover all] |
Triggered by | PROSITE; PS51246 |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Pseudomonadota>
Identifier |
|
Protein name |
|
Gene name |
|
else
Identifier |
|
Protein name |
|
Gene name |
|
end case
Comments
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case <OC:Pseudomonadota>
Function | Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. Presumably responsible for energy coupling to the transport system. |
Pathway | Cofactor biosynthesis; adenosylcobalamin biosynthesis. |
Subunit | Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry. |
else
Function | ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. |
Subunit | Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component). |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Peripheral membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Peripheral membrane protein. |
end case
case <OC:Pseudomonadota>
Similarity | Belongs to the ABC transporter superfamily. Cobalt importer (TC 3.A.1.18.1) family. |
else
Similarity | Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family. |
end case
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
case <OC:Pseudomonadota>
end case
Gene Ontology
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case <OC:Pseudomonadota>
GO:0006824; Biological process: cobalt ion transport.
GO:0015087; Molecular function: cobalt ion transmembrane transporter activity.
GO:0015087; Molecular function: cobalt ion transmembrane transporter activity.
end case
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Pfam | PF00005; ABC_tran; 1; |
NCBIfam | TIGR01166; CbiO; 1; |
PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
PS50893; ABC_TRANSPORTER_2; 1; trigger=PRU00434; |
Additional information
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Size range | 200-591 amino acids |
Related rules | PRU01700 |
Fusion | None |
Comments | In Pseudomonadota is part of a dedicated cobalt transporter; RHOCB is experimentally a member of this family but does not fit the PROSITE profile. In Bacillota (and probably other bacteria and archaea) this is an ABC subunit of an energy-coupling transporter that imports more than 1 substrate. See: PubMed=18931129; DOI=10.1128/JB.01208-08; Rodionov D.A., Hebbeln P., Eudes A., ter Beek J., Rodionova I.A., Erkens G.B., Slotboom D.J., Gelfand M.S., Osterman A.L., Hanson A.D., Eitinger T.; "A novel class of modular transporters for vitamins in prokaryotes."; J. Bacteriol. 191:42-51(2009). The subunit composition has been determined to be 2S:2T:A1:A2 PMID:23359690. |