HAMAP rule MF_01717
General rule information
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| Accession | MF_01717 |
| Dates | 11-OCT-2006 (Created) 16-JUN-2022 (Last updated, Version 18) |
| Name | ABC_ATPase_MglA |
| Scope | Bacteria |
| Template | P0AAG8 (MGLA_ECOLI) |
| Triggered by | PROSITE; PS51260 |
Propagated annotation
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Identifier, protein and gene names
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case not <AnyFeature:PS51254>
| Identifier |
|
| Protein name |
|
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| Gene name |
|
else
| Identifier |
|
| Protein name |
|
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end case
Comments
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case <OC:Bacteria> and not <AnyFeature:PS51254>
| Function | Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system. |
| Catalytic activity | RHEA:60156: ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate
EC 7.5.2.11 PhysiologicalDirection=left-to-right (RHEA:60157) |
| RHEA:72531: ATP + H2O + methyl beta-D-galactoside(out) = ADP + H(+) + methyl beta-D-galactoside(in) + phosphate
PhysiologicalDirection=left-to-right (RHEA:72532) |
|
| Subunit | The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB). |
| Similarity | Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family. |
else
| Function | Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and/or methyl galactoside import. Responsible for energy coupling to the transport system. |
| Catalytic activity | RHEA:29903: ATP + D-ribose(out) + H2O = ADP + D-ribose(in) + H(+) + phosphate
EC 7.5.2.7 |
| RHEA:60156: ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate
EC 7.5.2.11 |
|
| Similarity | Belongs to the ABC transporter superfamily. Carbohydrate importer 2 (CUT2) (TC 3.A.1.2) family. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Peripheral membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Peripheral membrane protein. |
end case
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0008643; Biological process: carbohydrate transport.
case not <AnyFeature:PS51254>
GO:0005354; Molecular function: galactose transmembrane transporter activity.
end case
case <OC:Bacteria>
GO:0005886; Cellular component: plasma membrane.
end case
Cross-references
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| Pfam | PF00005; ABC_tran; 1; |
| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
| PS50893; ABC_TRANSPORTER_2; 2; trigger=PRU00434; |
case <OC:Bacteria> and <AnyFeature:PS51254>
| PS51254; RBSA; 1; |
end case
Additional information
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| Size range | 450-550 amino acids |
| Related rules | PRU01700 |
| Fusion | None |
| Comments | Some of these proteins are related to two differents sugar ABC import subfamilies, (PRU01716-PRU01717) therefore it is not possible to assign their substrate. For those cases a specific annotation is propagated. |