HAMAP rule MF_01800
General rule information
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| Accession | MF_01800 |
| Dates | 9-DEC-2003 (Created) 19-NOV-2022 (Last updated, Version 27) |
| Name | MukB |
| Scope | Bacteria; Gammaproteobacteria |
| Template | P22523 (MUKB_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. |
| Subunit | Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ. |
| Subcellular location | Cytoplasm, nucleoid. Note=Restricted to the nucleoid region. |
| Domain | The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer. |
| Similarity | Belongs to the SMC family. MukB subfamily. |
Keywords
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Cytoplasm
Cell cycle
Cell division
Chromosome partition
DNA-binding
DNA condensation
ATP-binding
Nucleotide-binding
Coiled coil
Cell cycle
Cell division
Chromosome partition
DNA-binding
DNA condensation
ATP-binding
Nucleotide-binding
Coiled coil
Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0003677; Molecular function: DNA binding.
GO:0005524; Molecular function: ATP binding.
GO:0006260; Biological process: DNA replication.
GO:0007059; Biological process: chromosome segregation.
GO:0003677; Molecular function: DNA binding.
GO:0005524; Molecular function: ATP binding.
GO:0006260; Biological process: DNA replication.
GO:0007059; Biological process: chromosome segregation.
Cross-references
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| Pfam | PF04310; MukB; 1; |
Computed features
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| General | Coiled_coil; -; 1-unlimited; trigger=yes; |
Features
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| From: MUKB_ECOLI (P22523) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 34 | 41 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [AG]-x(4)-G-K-[ST] | ||||||||
| REGION | 666 | 783 | Flexible hinge | |||||||||
Additional information
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| Size range | 1479-1510 amino acids |
| Related rules | MF_01801 |
| Fusion | None |
| Comments | Despite a low sequence conservation, mukB is strongly related to smc (MF_01801), and displays the same function. |