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HAMAP rule MF_01800

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General rule information [?]

Accession MF_01800
Dates 9-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 27)
Name MukB
Bacteria; Gammaproteobacteria
Template P22523 (MUKB_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Chromosome partition protein MukB;
AltName: Full=Structural maintenance of chromosome-related protein;
Gene name

Comments [?]

Function Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
Subunit Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.
Subcellular location Cytoplasm, nucleoid. Note=Restricted to the nucleoid region.
Domain The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.
Similarity Belongs to the SMC family. MukB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0003677; Molecular function: DNA binding.
GO:0005524; Molecular function: ATP binding.
GO:0006260; Biological process: DNA replication.
GO:0007059; Biological process: chromosome segregation.

Cross-references [?]

Pfam PF04310; MukB; 1;

Computed features [?]

General Coiled_coil; -; 1-unlimited; trigger=yes;

Features [?]

From: MUKB_ECOLI (P22523)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     34     41       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [AG]-x(4)-G-K-[ST]  
REGION     666     783       Flexible hinge        

Additional information [?]

Size range 1479-1510 amino acids
Related rules MF_01801
Fusion None
Comments Despite a low sequence conservation, mukB is strongly related to smc (MF_01801), and displays the same function.