HAMAP rule MF_01800
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01800 |
| Accession | MF_01800 |
| Dates | 9-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 27) |
| Name | MukB |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P22523 (MUKB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01800 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MUKB |
| Protein name | RecName: Full=Chromosome partition protein MukB; AltName: Full=Structural maintenance of chromosome-related protein; |
| Gene name | Name=mukB; |
Comments
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| FUNCTION | Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. |
| SUBUNIT | Homodimerization via its hinge domain. Binds to DNA via its C- terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ. |
| SUBCELLULAR LOCATION | Cytoplasm, nucleoid. Note=Restricted to the nucleoid region. |
| DOMAIN | The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer. |
| SIMILARITY | Belongs to the SMC family. MukB subfamily. |
Keywords
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| Cytoplasm |
| Cell cycle |
| Cell division |
| Chromosome partition |
| DNA-binding |
| DNA condensation |
| ATP-binding |
| Nucleotide-binding |
| Coiled coil |
Gene Ontology
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| GO:0005737; Cellular component:cytoplasm |
| GO:0003677; Molecular function:DNA binding |
| GO:0005524; Molecular function:ATP binding |
| GO:0006260; Biological process:DNA replication |
| GO:0007059; Biological process:chromosome segregation |
Cross-references
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| Pfam | PF04310; MukB; 1; |
| General | Coiled_coil; -; 1-unlimited; |
Features
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| From: MUKB_ECOLI (P22523) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 34 | 41 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[AG]-x(4)-G-K-[ST] | ||||||||
| REGION | 666 | 783 | /note="Flexible hinge" | |||||||||
Additional information
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| Size range | 1479-1510 amino acids |
| Related rules |
MF_01801 |
| Fusion | Nter: None Cter: None |
| Comments | Despite a low sequence conservation, mukB is strongly related to smc (MF_01801), and displays the same function. |