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HAMAP rule MF_01800

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General rule information [?]

Accession MF_01800
Dates 9-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 27)
Name MukB
Scope(s) Bacteria
Template(s) P22523 (MUKB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01800 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MUKB
Protein name RecName: Full=Chromosome partition protein MukB;
AltName: Full=Structural maintenance of chromosome-related protein;
Gene name Name=mukB;

Comments [?]

FUNCTIONPlays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
SUBUNITHomodimerization via its hinge domain. Binds to DNA via its C- terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.
SUBCELLULAR LOCATIONCytoplasm, nucleoid. Note=Restricted to the nucleoid region.
DOMAINThe hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.
SIMILARITYBelongs to the SMC family. MukB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm
GO:0003677; Molecular function:DNA binding
GO:0005524; Molecular function:ATP binding
GO:0006260; Biological process:DNA replication
GO:0007059; Biological process:chromosome segregation

Cross-references [?]

Pfam PF04310; MukB; 1;
General Coiled_coil; -; 1-unlimited;

Features [?]

From: MUKB_ECOLI (P22523)
Key From To Description Tag Condition FTGroup
BINDING 34 41 /ligand="ATP"
REGION 666 783 /note="Flexible hinge"

Additional information [?]

Size range 1479-1510 amino acids
Related rules MF_01801
Fusion Nter: None Cter: None
Comments Despite a low sequence conservation, mukB is strongly related to smc (MF_01801), and displays the same function.

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