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Annotation rule MF_01816
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General rule information [?]

Accession MF_01816
Dates 17-AUG-2003 (Created)
19-NOV-2019 (Last updated, Version 25)
Name Recomb_XerS
Scope
Bacteria; Streptococcaceae
Templates A2RKP9 (XERS_LACLM); Q7ZAK7 (XERS_STRR6): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
XERS
Protein name
RecName: Full=Tyrosine recombinase XerS;
Gene name
xerS

Comments [?]

Function Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.
Activity regulation FtsK is required for recombination.
Subcellular location Cytoplasm.
Similarity Belongs to the 'phage' integrase family. XerS subfamily.

Keywords [?]


Gene Ontology [?]

GO:0009037; Molecular function: tyrosine-based site-specific recombinase activity.
GO:0007059; Biological process: chromosome segregation.
GO:0006310; Biological process: DNA recombination.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00589; Phage_integrase; 1;
PF02899; Phage_integr_N; 1;
PROSITE PS51900; CB; 1; trigger=PRU01248;
PS51898; TYR_RECOMBINASE; 1; trigger=PRU01246;

Features [?]

From: XERS_LACLM (A2RKP9)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     210     210             R  
ACT_SITE     234     234             K  
ACT_SITE     306     306             H  
ACT_SITE     309     309             R  
ACT_SITE     332     332             H  
ACT_SITE     341     341       O-(3'-phospho-DNA)-tyrosine intermediate     Y  

Additional information [?]

Size range 340-375 amino acids
Related rules None
Fusion None
Comments XerS is an alternative Xer recombination machinery found in Streptococci and Lactococci. It is related to Xerc/XerD tyrosine recombinases of E.coli.