HAMAP rule MF_01816
General rule information
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| Accession | MF_01816 |
| Dates | 17-AUG-2003 (Created)
19-NOV-2019 (Last updated, Version 25) |
| Name | Recomb_XerS |
| Scope(s) |
Bacteria Streptococcaceae |
| Template(s) | A2RKP9 (XERS_LACLM); Q7ZAK7 (XERS_STRR6); [ Recover all ] |
| Triggered by |
HAMAP; MF_01816 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | XERS |
| Protein name | RecName: Full=Tyrosine recombinase XerS; |
| Gene name | Name=xerS; |
Comments
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| FUNCTION | Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. |
| ACTIVITY REGULATION | FtsK is required for recombination. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the 'phage' integrase family. XerS subfamily. |
Keywords
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| Cell cycle |
| Cell division |
| Chromosome partition |
| Cytoplasm |
| DNA integration |
| DNA recombination |
| DNA-binding |
Gene Ontology
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| GO:0009037; Molecular function:tyrosine-based site-specific recombinase activity |
| GO:0007059; Biological process:chromosome segregation |
| GO:0006310; Biological process:DNA recombination |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF00589; Phage_integrase; 1; |
| Pfam | PF02899; Phage_integr_N; 1; |
| PROSITE | PS51900; CB; 1; |
| PROSITE | PS51898; TYR_RECOMBINASE; 1; |
Features
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| From: XERS_LACLM (A2RKP9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 210 | 210 | R | |||||||||
| ACT_SITE | 234 | 234 | K | |||||||||
| ACT_SITE | 306 | 306 | H | |||||||||
| ACT_SITE | 309 | 309 | R | |||||||||
| ACT_SITE | 332 | 332 | H | |||||||||
| ACT_SITE | 341 | 341 | /note="O-(3'-phospho-DNA)-tyrosine intermediate" | Y | ||||||||
Additional information
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| Size range | 340-375 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | XerS is an alternative Xer recombination machinery found in Streptococci and Lactococci. It is related to Xerc/XerD tyrosine recombinases of E.coli. |