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HAMAP rule MF_01816

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General rule information [?]

Accession MF_01816
Dates 17-AUG-2003 (Created)
19-NOV-2019 (Last updated, Version 25)
Name Recomb_XerS
Scope(s) Bacteria
Template(s) A2RKP9 (XERS_LACLM); Q7ZAK7 (XERS_STRR6); [ Recover all ]
Triggered by HAMAP; MF_01816 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier XERS
Protein name RecName: Full=Tyrosine recombinase XerS;
Gene name Name=xerS;

Comments [?]

FUNCTIONSite-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division.
ACTIVITY REGULATIONFtsK is required for recombination.
SIMILARITYBelongs to the 'phage' integrase family. XerS subfamily.

Keywords [?]

Gene Ontology [?]

GO:0009037; Molecular function:tyrosine-based site-specific recombinase activity
GO:0007059; Biological process:chromosome segregation
GO:0006310; Biological process:DNA recombination
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00589; Phage_integrase; 1;
Pfam PF02899; Phage_integr_N; 1;
PROSITE PS51900; CB; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 210 210 R
ACT_SITE 234 234 K
ACT_SITE 306 306 H
ACT_SITE 309 309 R
ACT_SITE 332 332 H
ACT_SITE 341 341 /note="O-(3'-phospho-DNA)-tyrosine intermediate" Y

Additional information [?]

Size range 340-375 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments XerS is an alternative Xer recombination machinery found in Streptococci and Lactococci. It is related to Xerc/XerD tyrosine recombinases of E.coli.

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