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HAMAP rule MF_01817

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General rule information [?]

Accession MF_01817
Dates 17-AUG-2003 (Created)
27-MAR-2023 (Last updated, Version 26)
Name Recomb_XerD_like
Bacteria; Streptococcaceae
Templates P0A4T0 (XERDL_STRR6); Q9CG32 (XERDL_LACLA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Tyrosine recombinase XerD-like;

Comments [?]

Function Putative tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site.
Subcellular location Cytoplasm.
Similarity Belongs to the 'phage' integrase family. XerD-like subfamily.

Keywords [?]

Gene Ontology [?]

GO:0009037; Molecular function: tyrosine-based site-specific recombinase activity.
GO:0006310; Biological process: DNA recombination.
GO:0006313; Biological process: DNA transposition.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00589; Phage_integrase; 1;
PF02899; Phage_integr_N; 1;
PROSITE PS51900; CB; 1; trigger=PRU01248;
PS51898; TYR_RECOMBINASE; 1; trigger=PRU01246;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     236     236       O-(3'-phospho-DNA)-tyrosine intermediate     Y  

Additional information [?]

Size range 238-253 amino acids
Related rules None
Fusion None
Comments Although strongly related to XerD, it constitutes a distinct protein family. In contrast to the classic XerD protein, it does not contain the Arg-His-Arg-His (R-H-R-H) sandwich residues that are clustered with the Tyr active site. It also lacks the C-terminal region which is known to mediate the interaction with XerC. It is therefore unknown whether it has tyrosine recombinase activity or acts as a regulator.