HAMAP rule MF_01818
General rule information
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Accession | MF_01818 |
Dates | 12-DEC-2003 (Created) 19-NOV-2022 (Last updated, Version 25) |
Name | RNase_Z_BN |
Scope | Bacteria
Archaea |
Templates | P0A8V0 (RBN_ECOLI); Q58897 (RNZ_METJA); P54548 (RNZ_BACSU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Enterobacterales>
Identifier |
|
Protein name |
|
Gene name |
|
else
Identifier |
|
Protein name |
|
Gene name |
|
end case
Comments
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case <OC:Enterobacterales>
Function | Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities. |
else
Function | Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. |
Catalytic activity | Reaction=Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.; EC=3.1.26.11; |
end case
case <FTGroup:1>
Cofactor | Zn(2+) Note: Binds 2 Zn(2+) ions. |
end case
Subunit | Homodimer. |
case <OC:Enterobacterales>
Similarity | Belongs to the RNase Z family. RNase BN subfamily. |
else
Similarity | Belongs to the RNase Z family. |
end case
Keywords
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case <OC:Enterobacterales>
end case
case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
case <OC:Enterobacterales>
GO:0004519; Molecular function: endonuclease activity.
GO:0004527; Molecular function: exonuclease activity.
GO:0004527; Molecular function: exonuclease activity.
else
GO:0042781; Molecular function: 3'-tRNA processing endoribonuclease activity.
end case
GO:0008033; Biological process: tRNA processing.
Cross-references
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Features
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From: RNZ_BACSU (P54548) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 67 | 67 | Proton acceptor | D | ||||||||
BINDING | 63 | 63 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 65 | 65 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 67 | 67 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic | D | 1 | |||||||
BINDING | 68 | 68 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 140 | 140 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 211 | 211 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /ligand_note="catalytic | D | 1 | |||||||
BINDING | 211 | 211 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic | D | 1 | |||||||
BINDING | 269 | 269 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /ligand_note="catalytic | H | 1 |
Additional information
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Size range | 220-407 amino acids |
Related rules | None |
Fusion | Nter: None; Cter: <Unknown> |
Comments | Was initially thought to be an arylsulfatase, given its similarity with the atsA family. |