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HAMAP rule MF_01820
General rule information
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| Accession | MF_01820 |
| Dates | 30-OCT-2003 (Created)
1-JUN-2023 (Last updated, Version 32) |
| Name | GTPase_RsgA |
| Scope(s) |
Bacteria Archaea Methanosarcinales |
| Template(s) | P39286 (RSGA_ECOLI); Q9X242 (RSGA_THEMA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01820 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RSGA |
| Protein name | RecName: Full=Small ribosomal subunit biogenesis GTPase RsgA; EC=3.6.1.-; |
| Gene name | Name=rsgA; |
Comments
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| FUNCTION | One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| SUBUNIT | Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. |
Keywords
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| Cytoplasm | |
| Hydrolase | |
| GTP-binding | |
| Nucleotide-binding | |
| Ribosome biogenesis | |
| RNA-binding | |
| rRNA-binding | |
| case <FTGroup:1> | |
| Zinc | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0003924; Molecular function:GTPase activity |
| GO:0005525; Molecular function:GTP binding |
| GO:0005737; Cellular component:cytoplasm |
| GO:0042274; Biological process:ribosomal small subunit biogenesis |
Cross-references
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| Pfam | PF03193; DUF258; 1; |
| NCBIfam | TIGR00157; TIGR00157; 1; |
| PROSITE | PS50936; ENGC_GTPASE; 1; |
| PROSITE | PS51721; G_CP; 1; |
Features
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| From: RSGA_SALTY (Q8ZKB0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 160 | 163 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[NTSA]-K-x-D | ||||||||
| BINDING | 214 | 222 | /ligand="GTP" /ligand_id="ChEBI:CHEBI:37565" |
[AG]-x(4)-G-K-[ST]-[TS] | ||||||||
| BINDING | 297 | 297 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 302 | 302 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 304 | 304 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 310 | 310 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 272-387 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | In contrast to most P-loop GTPases, which have a G1-G2-G3-G4 pattern of GTP-binding motifs, contains a permuted G4-G1-G2-G3 pattern. Often referred to as YjeQ. |