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Annotation rule MF_01821
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General rule information [?]

Accession MF_01821
Dates 12-DEC-2003 (Created)
19-NOV-2019 (Last updated, Version 22)
Name Helicase_RapA
Scope
Bacteria; Gammaproteobacteria
Template P60240 (RAPA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RAPA
Protein name
RecName: Full=RNA polymerase-associated protein RapA;
EC 3.6.4.-;
AltName: Full=ATP-dependent helicase HepA;
Gene name
rapA

Comments [?]

Function Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.
Subunit Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
Similarity Belongs to the SNF2/RAD54 helicase family. RapA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004386; Molecular function: helicase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006355; Biological process: regulation of transcription, DNA-templated.

Cross-references [?]

Pfam PF00271; Helicase_C; 1;
PF00176; SNF2_N; 1;
PROSITE PS00690; DEAH_ATP_HELICASE; 1;
PS51192; HELICASE_ATP_BIND_1; 1; trigger=PRU00541;
PS51194; HELICASE_CTER; 1; trigger=PRU00542;

Features [?]

From: RAPA_ECOLI (P60240)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     177     184       ATP     D-x-x-G-x-G-K-T  
MOTIF     280     283       DEAH box     D-E-[ALIV]-H  

Additional information [?]

Size range 556-1170 amino acids
Related rules None
Fusion None