HAMAP rule MF_01821

General rule information [?]

Accession	MF_01821
Dates	12-DEC-2003 (Created) 19-NOV-2022 (Last updated, Version 25)
Name	Helicase_RapA
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P60240 (RAPA_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01821 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RAPA
RecName: Full=RNA polymerase-associated protein RapA;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;<br /> AltName: Full=ATP-dependent helicase HepA;
Gene name	Name=rapA;

Comments [?]

FUNCTION	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.
SUBUNIT	Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
SIMILARITY	Belongs to the SNF2/RAD54 helicase family. RapA subfamily.

Keywords [?]

Transcription
Transcription regulation
Hydrolase
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Activator
ATP-binding
Nucleotide-binding
DNA-binding

Gene Ontology [?]

GO:0004386; Molecular function:helicase activity

GO:0005524; Molecular function:ATP binding

GO:0006355; Biological process:regulation of DNA-templated transcription

Cross-references [?]

Features [?]

From: RAPA_ECOLI (P60240)

Key

From

Description

Tag

Condition

FTGroup

BINDING

177

184

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

D-x-x-G-x-G-K-T

MOTIF

280

283

/note="DEAH box"

D-E-[ALIV]-H

Additional information [?]