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Annotation rule MF_01824
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General rule information [?]

Accession MF_01824
Dates 19-MAR-2004 (Created)
19-NOV-2019 (Last updated, Version 22)
Name PdxS
Templates P37527 (PDXS_BACSU); Q9WYU4 (PDXS_THEMA); O59080 (PDXS_PYRHO); Q5L3Y2 (PDXS_GEOKA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Pyridoxal 5'-phosphate synthase subunit PdxS;
Short=PLP synthase subunit PdxS;
AltName: Full=Pdx1;
Gene name

Comments [?]

Function Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Catalytic activity RHEA:31507: aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate
Pathway Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.
Subunit In the presence of PdxT, forms a dodecamer of heterodimers.
Similarity Belongs to the PdxS/SNZ family.

Keywords [?]

Gene Ontology [?]

GO:0036381; Molecular function: pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity.
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process.

Cross-references [?]

Pfam PF00218; IGPS; 1;
PF01680; SOR_SNZ; 1;
PIRSF PIRSF029271; Pdx1; 1;
TIGRFAMs TIGR00343; TIGR00343; 1;
PS51129; PDXS_SNZ_2; 1;

Features [?]

From: PDXS_PYRHO (O59080)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     278     279       D-ribose 5-phosphate binding     G-S  
ACT_SITE     87     87       Schiff-base intermediate with D-ribose 5-phosphate     K  
BINDING     30     30       D-ribose 5-phosphate     D  
BINDING     159     159       D-ribose 5-phosphate; via amide nitrogen     G  
BINDING     171     171       Glyceraldehyde 3-phosphate     [RKQ]  
BINDING     257     257       D-ribose 5-phosphate; via amide nitrogen     G  

Additional information [?]

Size range 280-338 amino acids
Related rules None
Fusion None