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HAMAP rule MF_01824

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General rule information [?]

Accession MF_01824
Dates 19-MAR-2004 (Created)
1-JUN-2023 (Last updated, Version 26)
Name PdxS
Scope(s) Bacteria
Archaea
Template(s) P37527 (PDXS_BACSU); Q9WYU4 (PDXS_THEMA); O59080 (PDXS_PYRHO); Q5L3Y2 (PDXS_GEOKA); [ Recover all ]
Triggered by HAMAP; MF_01824 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PDXS
Protein name RecName: Full=Pyridoxal 5'-phosphate synthase subunit PdxS;
                 Short=PLP synthase subunit PdxS;
                 EC=4.3.3.6;
AltName: Full=Pdx1;
Gene name Name=pdxS;

Comments [?]

FUNCTIONCatalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
CATALYTIC ACTIVITY Reaction=aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'- phosphate; Xref=Rhea:RHEA:31507, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:43474, ChEBI:CHEBI:58273, ChEBI:CHEBI:58359, ChEBI:CHEBI:59776, ChEBI:CHEBI:597326; EC=4.3.3.6;
PATHWAYCofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.
SUBUNITIn the presence of PdxT, forms a dodecamer of heterodimers.
SIMILARITYBelongs to the PdxS/SNZ family.

Keywords [?]


Gene Ontology [?]

GO:0036381; Molecular function:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
GO:0042823; Biological process:pyridoxal phosphate biosynthetic process

Cross-references [?]

Pfam PF00218; IGPS; 1;
Pfam PF01680; SOR_SNZ; 1;
PIRSF PIRSF029271; Pdx1; 1;
NCBIfam TIGR00343; TIGR00343; 1;
PROSITE PS01235; PDXS_SNZ_1; 1;
PROSITE PS51129; PDXS_SNZ_2; 1;

Features [?]

From: PDXS_PYRHO (O59080)
Key From To Description Tag Condition FTGroup
BINDING 278 279 /ligand="D-ribose 5-phosphate"
/ligand_id="ChEBI:CHEBI:78346"
G-S
ACT_SITE 87 87 /note="Schiff-base intermediate with D-ribose 5-phosphate" K
BINDING 30 30 /ligand="D-ribose 5-phosphate"
/ligand_id="ChEBI:CHEBI:78346"
D
BINDING 159 159 /ligand="D-ribose 5-phosphate"
/ligand_id="ChEBI:CHEBI:78346"
G
BINDING 171 171 /ligand="D-glyceraldehyde 3-phosphate"
/ligand_id="ChEBI:CHEBI:59776"
[RKQ]
BINDING 257 257 /ligand="D-ribose 5-phosphate"
/ligand_id="ChEBI:CHEBI:78346"
G

Additional information [?]

Size range 280-338 amino acids
Related rules None
Fusion Nter: None Cter: None



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