HAMAP rule MF_01824
General rule information
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| Accession | MF_01824 |
| Dates | 19-MAR-2004 (Created)
2-SEP-2024 (Last updated, Version 27) |
| Name | PdxS |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P37527 (PDXS_BACSU); Q9WYU4 (PDXS_THEMA); O59080 (PDXS_PYRHO); Q5L3Y2 (PDXS_GEOKA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01824 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PDXS |
| Protein name | RecName: Full=Pyridoxal 5'-phosphate synthase subunit PdxS; Short=PLP synthase subunit PdxS; EC=4.3.3.6; AltName: Full=Pdx1; |
| Gene name | Name=pdxS; |
Comments
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| FUNCTION | Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. |
| CATALYTIC ACTIVITY | Reaction=aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+); Xref=Rhea:RHEA:31507, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:43474, ChEBI:CHEBI:58273, ChEBI:CHEBI:58359, ChEBI:CHEBI:59776, ChEBI:CHEBI:597326; EC=4.3.3.6; |
| PATHWAY | Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. |
| SUBUNIT | In the presence of PdxT, forms a dodecamer of heterodimers. |
| SIMILARITY | Belongs to the PdxS/SNZ family. |
Keywords
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Gene Ontology
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| GO:0036381; Molecular function:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity |
| GO:0042823; Biological process:pyridoxal phosphate biosynthetic process |
Cross-references
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| Pfam | PF00218; IGPS; 1; |
| Pfam | PF01680; SOR_SNZ; 1; |
| PIRSF | PIRSF029271; Pdx1; 1; |
| NCBIfam | TIGR00343; TIGR00343; 1; |
| PROSITE | PS01235; PDXS_SNZ_1; 1; |
| PROSITE | PS51129; PDXS_SNZ_2; 1; |
Features
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| From: PDXS_PYRHO (O59080) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 278 | 279 | /ligand="D-ribose 5-phosphate" /ligand_id="ChEBI:CHEBI:78346" |
G-S | ||||||||
| ACT_SITE | 87 | 87 | /note="Schiff-base intermediate with D-ribose 5-phosphate" | K | ||||||||
| BINDING | 30 | 30 | /ligand="D-ribose 5-phosphate" /ligand_id="ChEBI:CHEBI:78346" |
D | ||||||||
| BINDING | 159 | 159 | /ligand="D-ribose 5-phosphate" /ligand_id="ChEBI:CHEBI:78346" |
G | ||||||||
| BINDING | 171 | 171 | /ligand="D-glyceraldehyde 3-phosphate" /ligand_id="ChEBI:CHEBI:59776" |
[RKQ] | ||||||||
| BINDING | 257 | 257 | /ligand="D-ribose 5-phosphate" /ligand_id="ChEBI:CHEBI:78346" |
G | ||||||||
Additional information
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| Size range | 280-338 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |