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Annotation rule MF_01825 |
Accession | MF_01825 |
Dates | 19-MAR-2004 (Created) 19-NOV-2019 (Last updated, Version 16) |
Name | PdxB |
Scope | Bacteria; Bacteroidetes
Bacteria; Gammaproteobacteria |
Templates | P05459 (PDXB_ECOLI); Q9I3W9 (PDXB_PSEAE): [Recover all] |
Triggered by |
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Protein name |
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Gene name |
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Function | Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate. |
Catalytic activity | RHEA:18829: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + H(+) + NADH
EC 1.1.1.290 |
Pathway | Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 2/5. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily. |
PROSITE | PS00065; D_2_HYDROXYACID_DH_1; 1; |
PS00670; D_2_HYDROXYACID_DH_2; 1; | |
PS00671; D_2_HYDROXYACID_DH_3; 1; | |
Pfam | PF00389; 2-Hacid_dh; 1; |
PF02826; 2-Hacid_dh_C; 1; | |
PRINTS | PR00411; PNDRDTASEI; 1; |
From: PDXB_PSEAE (Q9I3W9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND (Optional) | 126 | 127 | NAD | Q-V | ||||||||
NP_BIND (Optional) | 206 | 208 | NAD | A-S-R | ||||||||
ACT_SITE | 208 | 208 | R | |||||||||
ACT_SITE | 237 | 237 | E | |||||||||
ACT_SITE | 254 | 254 | Proton donor | H | ||||||||
BINDING (Optional) | 45 | 45 | Substrate | [ST] | ||||||||
BINDING (Optional) | 66 | 66 | Substrate | T | ||||||||
BINDING (Optional) | 146 | 146 | NAD | D | ||||||||
BINDING (Optional) | 175 | 175 | NAD; via carbonyl oxygen | T | ||||||||
BINDING (Optional) | 232 | 232 | NAD | D | ||||||||
BINDING (Optional) | 257 | 257 | NAD; via amide nitrogen | G | ||||||||
BINDING (Optional) | 258 | 258 | Substrate | Y |
Size range | 345-393 amino acids |
Related rules | None |
Fusion | None |
Comments | The pyridoxal phosphate can be synthetised from two separate branches: the pdxA branch (that requires the gapA (or epd), pdxB, serC and pdxA enzymes) and the pdxJ branch (that requires the dxs and pdxJ enzymes) that start different precursors. Both branches for the last step (pdxH) of the from pyridoxal phosphate pathway. |