HAMAP rule MF_01840

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01840
Accession	MF_01840
Dates	28-JUL-2005 (Created) 02-SEP-2024 (Last updated, Version 29)
Name	AcsF
Scope(s)	Bacteria Cyanobacteriota Alphaproteobacteria Betaproteobacteria Plastid
Template(s)	P0DJN9; [ Recover all ]
Triggered by	HAMAP; MF_01840 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ACSF
case <OC:Bacteria> and not <OC:Cyanobacteriota>
Protein name	RecName: Full=Aerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase; Short=Aerobic Mg-protoporphyrin IX monomethyl ester oxidative cyclase; EC=1.14.13.81;
else case <OC:Cyanobacteriota> or <OG:Chloroplast>
Protein name	RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase; Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase; EC=1.14.13.81;
else
Protein name	RecName: Full=Probable magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase; Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase; EC=1.14.13.81;
end case
Gene name	Name=acsF;

Comments [?]

FUNCTION	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).
CATALYTIC ACTIVITY	Reaction=Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 + 2 H(+) = 3,8-divinyl protochlorophyllide a + 3 NADP(+) + 5 H2O; Xref=Rhea:RHEA:33235, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58632, ChEBI:CHEBI:60491; EC=1.14.13.81;
COFACTOR	Name=Fe cation; Xref=ChEBI:CHEBI:24875;
case <OC:Bacteria> and not <OC:Cyanobacteriota>
PATHWAY	Porphyrin-containing compound metabolism; bacteriochlorophyll biosynthesis (light-independent).
end case
case <OC:Cyanobacteriota> or <OG:Chloroplast>
PATHWAY	Porphyrin-containing compound metabolism; chlorophyll biosynthesis (light-independent).
end case
case <OG:Chloroplast>
SUBCELLULAR LOCATION	Plastid, chloroplast.
end case
SIMILARITY	Belongs to the AcsF family.

Keywords [?]

case <OC:Bacteria> and not <OC:Cyanobacteriota>
Bacteriochlorophyll biosynthesis
end case
Chlorophyll biosynthesis
Iron
Metal-binding
NADP
Oxidoreductase
Photosynthesis

Gene Ontology [?]

case <OCellular component:Bacteria> and not <OC:Cyanobacteriota>
GO:0036070; Biological process:light-independent bacteriochlorophyll biosynthetic process
end case
case <OCellular component:Cyanobacteriota> or <OG:Chloroplast>
GO:0036068; Biological process:light-independent chlorophyll biosynthetic process
end case
GO:0005506; Molecular function:iron ion binding
GO:0048529; Molecular function:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
GO:0015979; Biological process:photosynthesis
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam	PF02915; Rubrerythrin; 1;
NCBIfam	TIGR02029; AcsF; 1;

Features [?]

Additional information [?]

Size range	299-390 amino acids
Related rules	None
Fusion	Nter: None Cter: None

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