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HAMAP rule MF_01840

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General rule information [?]

Accession MF_01840
Dates 28-JUL-2005 (Created)
1-JUN-2023 (Last updated, Version 26)
Name AcsF
Scope(s) Bacteria
Template(s) P0DJN9 (ACSF_RUBGE); [ Recover all ]
Triggered by HAMAP; MF_01840 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACSF
case <OC:Bacteria> and not <OC:Cyanobacteriota>
Protein name RecName: Full=Aerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
                 Short=Aerobic Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
else case <OC:Cyanobacteriota> or <OG:Chloroplast>
Protein name RecName: Full=Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
                 Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
Protein name RecName: Full=Probable magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase;
                 Short=Mg-protoporphyrin IX monomethyl ester oxidative cyclase;
end case
Gene name Name=acsF;

Comments [?]

FUNCTIONCatalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).
CATALYTIC ACTIVITY Reaction=2 H(+) + Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = 3,8-divinyl protochlorophyllide a + 5 H2O + 3 NADP(+); Xref=Rhea:RHEA:33235, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:58632, ChEBI:CHEBI:60491; EC=;
COFACTOR Name=Fe cation; Xref=ChEBI:CHEBI:24875;
case <OC:Bacteria> and not <OC:Cyanobacteriota>
PATHWAYPorphyrin-containing compound metabolism; bacteriochlorophyll biosynthesis (light-independent).
end case
case <OC:Cyanobacteriota> or <OG:Chloroplast>
PATHWAYPorphyrin-containing compound metabolism; chlorophyll biosynthesis (light-independent).
end case
case <OG:Chloroplast>
SUBCELLULAR LOCATIONPlastid, chloroplast.
end case
SIMILARITYBelongs to the AcsF family.

Keywords [?]

Gene Ontology [?]

case <OCellular component:Bacteria> and not <OC:Cyanobacteriota>
GO:0030494; Biological process:bacteriochlorophyll biosynthetic process
end case
case <OCellular component:Cyanobacteriota> or <OG:Chloroplast>
GO:0015995; Biological process:chlorophyll biosynthetic process
end case
GO:0005506; Molecular function:iron ion binding
GO:0048529; Molecular function:magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity
GO:0015979; Biological process:photosynthesis
case <OG:Chloroplast>
GO:0009507; Cellular component:chloroplast
end case

Cross-references [?]

Pfam PF02915; Rubrerythrin; 1;
NCBIfam TIGR02029; AcsF; 1;

Features [?]

Additional information [?]

Size range 299-390 amino acids
Related rules None
Fusion Nter: None Cter: None

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