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HAMAP rule MF_01844

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General rule information [?]

Accession MF_01844
Dates 22-APR-2008 (Created)
1-JUN-2023 (Last updated, Version 26)
Name NhaA
Scope(s) Bacteria
Template(s) P13738 (NHAA_ECOLI); O85187 (NHAA_VIBCH); Q56725 (NHAA_VIBPA); [ Recover all ]
Triggered by HAMAP; MF_01844 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NHAA
Protein name RecName: Full=Na(+)/H(+) antiporter NhaA;
AltName: Full=Sodium/proton antiporter NhaA;
Gene name Name=nhaA;

Comments [?]

FUNCTIONNa(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
CATALYTIC ACTIVITY Reaction=2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out); Xref=Rhea:RHEA:29251, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29252;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.

Keywords [?]

Gene Ontology [?]

GO:0015297; Molecular function:antiporter activity
GO:0015081; Molecular function:sodium ion transmembrane transporter activity
GO:0006814; Biological process:sodium ion transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF06965; Na_H_antiport_1; 1;
NCBIfam TIGR00773; NhaA; 1;
General Transmembrane; -; 9-12;

Features [?]

From: NHAA_ECOLI (P13738)
Key From To Description Tag Condition FTGroup
case <OC:Escherichia> or <OC:Shigella>
TOPO_DOM Nter 11 /note="Cytoplasmic"
TRANSMEM 12 31 /note="Helical; Name=1"
TOPO_DOM 32 58 /note="Periplasmic"
TRANSMEM 59 80 /note="Helical; Name=2"
TOPO_DOM 81 96 /note="Cytoplasmic"
TRANSMEM 97 116 /note="Helical; Name=3"
TOPO_DOM 117 122 /note="Periplasmic"
TRANSMEM 123 130 /note="Helical; Name=4"
TOPO_DOM 131 154 /note="Cytoplasmic"
TRANSMEM 155 176 /note="Helical; Name=5"
TOPO_DOM 177 180 /note="Periplasmic"
TRANSMEM 181 200 /note="Helical; Name=6"
TOPO_DOM 201 204 /note="Cytoplasmic"
TRANSMEM 205 222 /note="Helical; Name=7"
TOPO_DOM 223 223 /note="Periplasmic"
TRANSMEM 224 236 /note="Helical; Name=8"
TOPO_DOM 237 253 /note="Cytoplasmic"
TRANSMEM 254 272 /note="Helical; Name=9"
TOPO_DOM 273 286 /note="Periplasmic"
TRANSMEM 287 310 /note="Helical; Name=10"
TOPO_DOM 311 339 /note="Cytoplasmic"
TRANSMEM 340 350 /note="Helical; Name=11"
TOPO_DOM 351 357 /note="Periplasmic"
TRANSMEM 358 380 /note="Helical; Name=12"
TOPO_DOM 381 Cter /note="Cytoplasmic"
end case

Additional information [?]

Size range 376-503 amino acids
Related rules None
Fusion Nter: <Unknown>; <Thioredoxin domain> Cter: <Thioredoxin domain>; <Peptidase S49>
Comments Some of the Rickettsiales are shorter than orthologs; sequences are not shown in alignment and not taken into account in size range.

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