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Annotation rule MF_01844
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General rule information [?]

Accession MF_01844
Dates 22-APR-2008 (Created)
19-NOV-2019 (Last updated, Version 21)
Name NhaA
Templates P13738 (NHAA_ECOLI); O85187 (NHAA_VIBCH); Q56725 (NHAA_VIBPA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Na(+)/H(+) antiporter NhaA;
AltName: Full=Sodium/proton antiporter NhaA;
Gene name

Comments [?]

Function Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0015297; Molecular function: antiporter activity.
GO:0015081; Molecular function: sodium ion transmembrane transporter activity.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF06965; Na_H_antiport_1; 1;
TIGRFAMs TIGR00773; NhaA; 1;

Computed features [?]

case not <OC:Escherichia> and not <OC:Shigella>
General Transmembrane; -; 9-12; trigger=yes;
end case

Features [?]

case <OC:Escherichia> or <OC:Shigella>
From: NHAA_ECOLI (P13738)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     11       Cytoplasmic        
TRANSMEM     12     30       Helical        
TOPO_DOM     31     58       Periplasmic        
TRANSMEM     59     85       Helical        
TOPO_DOM     86     94       Cytoplasmic        
TRANSMEM     95     116       Helical        
TOPO_DOM     117     120       Periplasmic        
TRANSMEM     121     143       Helical        
TOPO_DOM     144     149       Cytoplasmic        
TRANSMEM     150     175       Helical        
TOPO_DOM     176     181       Periplasmic        
TRANSMEM     182     200       Helical        
TOPO_DOM     201     204       Cytoplasmic        
TRANSMEM     205     218       Helical        
TOPO_DOM     219     222       Periplasmic        
TRANSMEM     223     236       Helical        
TOPO_DOM     237     246       Cytoplasmic        
TRANSMEM     247     271       Helical        
TOPO_DOM     272     289       Periplasmic        
TRANSMEM     290     311       Helical        
TOPO_DOM     312     326       Cytoplasmic        
TRANSMEM     327     350       Helical        
TOPO_DOM     351     356       Periplasmic        
TRANSMEM     357     382       Helical        
TOPO_DOM     383     Cter       Cytoplasmic        
end case

Additional information [?]

Size range 376-503 amino acids
Related rules None
Fusion Nter: <Unknown>, <Thioredoxin domain>; Cter: <Thioredoxin domain>, <Peptidase S49>
Comments Some of the Rickettsiales are shorter than orthologs; sequences are not shown in alignment and not taken into account in size range.