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| Annotation rule MF_01844 |
General rule information
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| Accession | MF_01844 |
| Dates | 22-APR-2008 (Created) 19-NOV-2019 (Last updated, Version 21) |
| Name | NhaA |
| Scope | Bacteria |
| Templates | P13738 (NHAA_ECOLI); O85187 (NHAA_VIBCH); Q56725 (NHAA_VIBPA): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. |
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
| Similarity | Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0015297; Molecular function: antiporter activity.
GO:0015081; Molecular function: sodium ion transmembrane transporter activity.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.
GO:0015081; Molecular function: sodium ion transmembrane transporter activity.
GO:0006814; Biological process: sodium ion transport.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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case not <OC:Escherichia> and not <OC:Shigella>
| General | Transmembrane; -; 9-12; trigger=yes; |
end case
Features
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case <OC:Escherichia> or <OC:Shigella>
| From: NHAA_ECOLI (P13738) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 11 | Cytoplasmic | |||||||||
| TRANSMEM | 12 | 30 | Helical | |||||||||
| TOPO_DOM | 31 | 58 | Periplasmic | |||||||||
| TRANSMEM | 59 | 85 | Helical | |||||||||
| TOPO_DOM | 86 | 94 | Cytoplasmic | |||||||||
| TRANSMEM | 95 | 116 | Helical | |||||||||
| TOPO_DOM | 117 | 120 | Periplasmic | |||||||||
| TRANSMEM | 121 | 143 | Helical | |||||||||
| TOPO_DOM | 144 | 149 | Cytoplasmic | |||||||||
| TRANSMEM | 150 | 175 | Helical | |||||||||
| TOPO_DOM | 176 | 181 | Periplasmic | |||||||||
| TRANSMEM | 182 | 200 | Helical | |||||||||
| TOPO_DOM | 201 | 204 | Cytoplasmic | |||||||||
| TRANSMEM | 205 | 218 | Helical | |||||||||
| TOPO_DOM | 219 | 222 | Periplasmic | |||||||||
| TRANSMEM | 223 | 236 | Helical | |||||||||
| TOPO_DOM | 237 | 246 | Cytoplasmic | |||||||||
| TRANSMEM | 247 | 271 | Helical | |||||||||
| TOPO_DOM | 272 | 289 | Periplasmic | |||||||||
| TRANSMEM | 290 | 311 | Helical | |||||||||
| TOPO_DOM | 312 | 326 | Cytoplasmic | |||||||||
| TRANSMEM | 327 | 350 | Helical | |||||||||
| TOPO_DOM | 351 | 356 | Periplasmic | |||||||||
| TRANSMEM | 357 | 382 | Helical | |||||||||
| TOPO_DOM | 383 | Cter | Cytoplasmic | |||||||||
end case
Additional information
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| Size range | 376-503 amino acids |
| Related rules | None |
| Fusion | Nter: <Unknown>, <Thioredoxin domain>; Cter: <Thioredoxin domain>, <Peptidase S49> |
| Comments | Some of the Rickettsiales are shorter than orthologs; sequences are not shown in alignment and not taken into account in size range. |