HAMAP rule MF_01847
General rule information
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| Accession | MF_01847 |
| Dates | 4-JUN-2008 (Created)
1-JUN-2023 (Last updated, Version 18) |
| Name | HMP_PP_phosphat |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P46891 (COF_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01847 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | COF |
| Protein name | RecName: Full=HMP-PP phosphatase; EC=3.6.1.-; |
| Gene name | Name=cof; |
Comments
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| FUNCTION | Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P). |
| CATALYTIC ACTIVITY | Reaction=4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4- amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate; Xref=Rhea:RHEA:27914, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57841, ChEBI:CHEBI:58354; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SIMILARITY | Belongs to the HAD-like hydrolase superfamily. Cof family. |
Keywords
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Gene Ontology
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| GO:0000287; Molecular function:magnesium ion binding |
| GO:0016791; Molecular function:phosphatase activity |
Cross-references
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| PROSITE | PS01228; COF_1; 1; |
| PROSITE | PS01229; COF_2; 1; |
| Pfam | PF00702; Hydrolase; 1; |
| Pfam | PF08282; Hydrolase_3; 1; |
| NCBIfam | TIGR00099; Cof-subfamily; 1; |
| NCBIfam | TIGR01484; HAD-SF-IIB; 1; |
Features
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| From: COF_ECOLI (P46891) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 8 | 8 | /note="Nucleophile" | D | ||||||||
| BINDING | 8 | 8 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 10 | 10 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| BINDING | 212 | 212 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
Additional information
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| Size range | 260-274 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The N-terminus of ECOLC is shorter. SHIDS is truncated and probably not functional. These sequences have not been included in the alignment. |