 |
|
| Annotation rule MF_01847 |
General rule information
[?]
| Accession | MF_01847 |
| Dates | 4-JUN-2008 (Created) 19-NOV-2019 (Last updated, Version 15) |
| Name | HMP_PP_phosphat |
| Scope | Bacteria; Enterobacterales |
| Template | P46891 (COF_ECOLI) |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
| Protein name |
|
||||||||
| Gene name |
|
Comments
[?]
| Function | Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P). |
| Catalytic activity | RHEA:27914: 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate |
| Cofactor | Mg(2+) |
| Similarity | Belongs to the HAD-like hydrolase superfamily. Cof family. |
Keywords
[?]
Gene Ontology
[?]
GO:0000287; Molecular function: magnesium ion binding.
GO:0016791; Molecular function: phosphatase activity.
GO:0016791; Molecular function: phosphatase activity.
Cross-references
[?]
| PROSITE | PS01228; COF_1; 1; |
| PS01229; COF_2; 1; | |
| Pfam | PF00702; Hydrolase; 1; |
| PF08282; Hydrolase_3; 1; | |
| TIGRFAMs | TIGR00099; Cof-subfamily; 1; |
| TIGR01484; HAD-SF-IIB; 1; |
Features
[?]
| From: COF_ECOLI (P46891) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 8 | 8 | Nucleophile | D | ||||||||
| METAL | 8 | 8 | Magnesium | D | ||||||||
| METAL | 10 | 10 | Magnesium; via carbonyl oxygen | D | ||||||||
| METAL | 212 | 212 | Magnesium | D | ||||||||
Additional information
[?]
| Size range | 260-274 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | The N-terminus of ECOLC is shorter. SHIDS is truncated and probably not functional. These sequences have not been included in the alignment. |