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HAMAP rule MF_01847

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General rule information [?]

Accession MF_01847
Dates 4-JUN-2008 (Created)
1-JUN-2023 (Last updated, Version 18)
Name HMP_PP_phosphat
Scope(s) Bacteria
Template(s) P46891 (COF_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01847 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier COF
Protein name RecName: Full=HMP-PP phosphatase;
Gene name Name=cof;

Comments [?]

FUNCTIONCatalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P).
CATALYTIC ACTIVITY Reaction=4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4- amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate; Xref=Rhea:RHEA:27914, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57841, ChEBI:CHEBI:58354;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SIMILARITYBelongs to the HAD-like hydrolase superfamily. Cof family.

Keywords [?]

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding
GO:0016791; Molecular function:phosphatase activity

Cross-references [?]

PROSITE PS01228; COF_1; 1;
PROSITE PS01229; COF_2; 1;
Pfam PF00702; Hydrolase; 1;
Pfam PF08282; Hydrolase_3; 1;
NCBIfam TIGR00099; Cof-subfamily; 1;
NCBIfam TIGR01484; HAD-SF-IIB; 1;

Features [?]

From: COF_ECOLI (P46891)
Key From To Description Tag Condition FTGroup
ACT_SITE 8 8 /note="Nucleophile" D
BINDING 8 8 /ligand="Mg(2+)"
BINDING 10 10 /ligand="Mg(2+)"
BINDING 212 212 /ligand="Mg(2+)"

Additional information [?]

Size range 260-274 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The N-terminus of ECOLC is shorter. SHIDS is truncated and probably not functional. These sequences have not been included in the alignment.

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