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Annotation rule MF_01847
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General rule information [?]

Accession MF_01847
Dates 4-JUN-2008 (Created)
19-NOV-2019 (Last updated, Version 15)
Name HMP_PP_phosphat
Scope
Bacteria; Enterobacterales
Template P46891 (COF_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COF
Protein name
RecName: Full=HMP-PP phosphatase;
EC 3.6.1.-;
Gene name
cof

Comments [?]

Function Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).
Catalytic activity RHEA:27914: 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + H(+) + phosphate
Cofactor Mg(2+)
Similarity Belongs to the HAD-like hydrolase superfamily. Cof family.

Keywords [?]


Gene Ontology [?]

GO:0000287; Molecular function: magnesium ion binding.
GO:0016791; Molecular function: phosphatase activity.

Cross-references [?]

PROSITE PS01228; COF_1; 1;
PS01229; COF_2; 1;
Pfam PF00702; Hydrolase; 1;
PF08282; Hydrolase_3; 1;
TIGRFAMs TIGR00099; Cof-subfamily; 1;
TIGR01484; HAD-SF-IIB; 1;

Features [?]

From: COF_ECOLI (P46891)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     8     8       Nucleophile     D  
METAL     8     8       Magnesium     D  
METAL     10     10       Magnesium; via carbonyl oxygen     D  
METAL     212     212       Magnesium     D  

Additional information [?]

Size range 260-274 amino acids
Related rules None
Fusion None
Comments The N-terminus of ECOLC is shorter. SHIDS is truncated and probably not functional. These sequences have not been included in the alignment.