HAMAP rule MF_01856

General rule information [?]

Accession	MF_01856
Dates	5-FEB-2009 (Created) 19-NOV-2022 (Last updated, Version 14)

Name	16SrRNA_methyltr_B

Scope

Bacteria; Enterobacterales

Template

P36929 (RSMB_ECOLI)

Triggered by

HAMAP; MF_01856 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RSMB

Protein name

RecName:		Full=Ribosomal RNA small subunit methyltransferase B;
		EC 2.1.1.176;
AltName:		Full=16S rRNA m5C967 methyltransferase;
AltName:		Full=rRNA (cytosine-C(5)-)-methyltransferase RsmB;

Gene name

rsmB, sun

Comments [?]

Function	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
Catalytic activity	RHEA:42748: cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine EC 2.1.1.176
Subcellular location	Cytoplasm.
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

Keywords [?]

Cytoplasm
Methyltransferase
RNA-binding
rRNA processing
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0016434; Molecular function: rRNA (cytosine) methyltransferase activity.
GO:0031167; Biological process: rRNA methylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS01153; NOL1_NOP2_SUN; 1;
Pfam	PF01189; Nol1_Nop2_Fmu; 1;
	PF01029; NusB; 1;
TIGRFAMs	TIGR00563; RsmB; 1;
PROSITE	PS01153; NOL1_NOP2_SUN; 1;
	PS51686; SAM_MT_RSMB_NOP; 1;

Features [?]

From: RSMB_ECOLI (P36929)

Key From To Description Tag Condition FTGroup

BINDING 254 260 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 [ACSV]-[ACPS]-[AGP]-[PQ]-[AG]-[GINS]-K

ACT_SITE 375 375 Nucleophile C

BINDING 277 277 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 D

BINDING 303 303 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 D

BINDING 322 322 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 D

Additional information [?]

Size range	422-433 amino acids
Related rules	None
Fusion	None
Comments	The family is restricted to Enterobacterales in order to avoid wrong matches.

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