HAMAP rule MF_01858
General rule information
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Accession | MF_01858 |
Dates | 9-FEB-2009 (Created)
19-NOV-2019 (Last updated, Version 14) |
Name | 23SrRNA_methyltr_KL |
Scope(s) |
Bacteria |
Template(s) | P75864 (RLMKL_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01858 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | RLMKL |
Protein name | RecName: Full=Ribosomal RNA large subunit methyltransferase K/L; Includes: RecName: Full=23S rRNA m2G2445 methyltransferase; EC=2.1.1.173; AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RlmL; Includes: RecName: Full=23S rRNA m7G2069 methyltransferase; EC=2.1.1.264; AltName: Full=rRNA (guanine-N(7)-)-methyltransferase RlmK; |
Gene name | Name=rlmL; |
Comments
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FUNCTION | Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. |
CATALYTIC ACTIVITY | Reaction=guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42740, Rhea:RHEA-COMP:10215, Rhea:RHEA-COMP:10216, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.173; |
CATALYTIC ACTIVITY | Reaction=guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43772, Rhea:RHEA-COMP:10688, Rhea:RHEA-COMP:10689, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.264; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the methyltransferase superfamily. RlmKL family. |
Keywords
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Gene Ontology
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GO:0052915; Molecular function:23S rRNA (guanine(2445)-N(2))-methyltransferase activity |
GO:0070043; Molecular function:rRNA (guanine-N7-)-methyltransferase activity |
GO:0031167; Biological process:rRNA methylation |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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PROSITE | PS51165; THUMP; 1; |
PROSITE | PS01261; UPF0020; 1; |
Pfam | PF03602; Cons_hypoth95; 0-1; |
Pfam | PF02926; THUMP; 1; |
Pfam | PF01170; UPF0020; 1; |
PIRSF | PIRSF037618; RNA_Mtase_bacteria_prd; 1; |
Features
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Additional information
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Size range | 676-807 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |