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HAMAP rule MF_01858

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General rule information [?]

Accession MF_01858
Dates 9-FEB-2009 (Created)
19-NOV-2019 (Last updated, Version 14)
Name 23SrRNA_methyltr_KL
Scope(s) Bacteria
Template(s) P75864 (RLMKL_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01858 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RLMKL
Protein name RecName: Full=Ribosomal RNA large subunit methyltransferase K/L;
RecName: Full=23S rRNA m2G2445 methyltransferase;
AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RlmL;
RecName: Full=23S rRNA m7G2069 methyltransferase;
AltName: Full=rRNA (guanine-N(7)-)-methyltransferase RlmK;
Gene name Name=rlmL;

Comments [?]

FUNCTIONSpecifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
CATALYTIC ACTIVITY Reaction=guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42740, Rhea:RHEA-COMP:10215, Rhea:RHEA-COMP:10216, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=;
CATALYTIC ACTIVITY Reaction=guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:43772, Rhea:RHEA-COMP:10688, Rhea:RHEA-COMP:10689, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=;
SIMILARITYBelongs to the methyltransferase superfamily. RlmKL family.

Keywords [?]

Gene Ontology [?]

GO:0052915; Molecular function:23S rRNA (guanine(2445)-N(2))-methyltransferase activity
GO:0070043; Molecular function:rRNA (guanine-N7-)-methyltransferase activity
GO:0031167; Biological process:rRNA methylation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE PS01261; UPF0020; 1;
Pfam PF03602; Cons_hypoth95; 0-1;
Pfam PF02926; THUMP; 1;
Pfam PF01170; UPF0020; 1;
PIRSF PIRSF037618; RNA_Mtase_bacteria_prd; 1;

Features [?]

Additional information [?]

Size range 676-807 amino acids
Related rules None
Fusion Nter: None Cter: None

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