HAMAP rule MF_01858

General rule information [?]

Accession	MF_01858
Dates	9-FEB-2009 (Created) 2-SEP-2024 (Last updated, Version 15)
Name	23SrRNA_methyltr_KL
Scope(s)	Bacteria
Template(s)	P75864 (RLMKL_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01858 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RLMKL
Protein name	RecName: Full=Ribosomal RNA large subunit methyltransferase K/L; Includes: RecName: Full=23S rRNA m2G2445 methyltransferase; EC=2.1.1.173; AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RlmL; Includes: RecName: Full=23S rRNA m7G2069 methyltransferase; EC=2.1.1.264; AltName: Full=rRNA (guanine-N(7)-)-methyltransferase RlmK;
Gene name	Name=rlmL;

Comments [?]

FUNCTION	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
CATALYTIC ACTIVITY	Reaction=guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = N(2)- methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:42740, Rhea:RHEA-COMP:10215, Rhea:RHEA-COMP:10216, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.173;
CATALYTIC ACTIVITY	Reaction=guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = N(2)- methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:43772, Rhea:RHEA-COMP:10688, Rhea:RHEA-COMP:10689, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.264;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the methyltransferase superfamily. RlmKL family.

Keywords [?]

Gene Ontology [?]

GO:0052915; Molecular function:23S rRNA (guanine(2445)-N(2))-methyltransferase activity

GO:0070043; Molecular function:rRNA (guanine-N7-)-methyltransferase activity

GO:0031167; Biological process:rRNA methylation

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]