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HAMAP rule MF_01858

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General rule information [?]

Accession MF_01858
Dates 9-FEB-2009 (Created)
19-NOV-2019 (Last updated, Version 14)
Name 23SrRNA_methyltr_KL
Scope
Bacteria
Template P75864 (RLMKL_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RLMKL
Protein name
RecName: Full=Ribosomal RNA large subunit methyltransferase K/L;
Includes:
RecName: Full=23S rRNA m2G2445 methyltransferase;
EC 2.1.1.173;
AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RlmL;
Includes:
RecName: Full=23S rRNA m7G2069 methyltransferase;
EC 2.1.1.264;
AltName: Full=rRNA (guanine-N(7)-)-methyltransferase RlmK;
Gene name
rlmL

Comments [?]

Function Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
Catalytic activity RHEA:42740: guanosine(2445) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine
EC 2.1.1.173
RHEA:43772: guanosine(2069) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(2)-methylguanosine(2069) in 23S rRNA + S-adenosyl-L-homocysteine
EC 2.1.1.264
Subcellular location Cytoplasm.
Similarity Belongs to the methyltransferase superfamily. RlmKL family.

Keywords [?]

Cytoplasm
Methyltransferase
rRNA processing
S-adenosyl-L-methionine
Transferase

Gene Ontology [?]

GO:0052915; Molecular function: 23S rRNA (guanine(2445)-N(2))-methyltransferase activity.
GO:0070043; Molecular function: rRNA (guanine-N7-)-methyltransferase activity.
GO:0031167; Biological process: rRNA methylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS51165; THUMP; 1; trigger=PRU00529;
PS01261; UPF0020; 1;
Pfam PF03602; Cons_hypoth95; 0-1;
PF02926; THUMP; 1;
PF01170; UPF0020; 1;
PIRSF PIRSF037618; RNA_Mtase_bacteria_prd; 1;

Additional information [?]

Size range 676-807 amino acids
Related rules None
Fusion None


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