HAMAP rule MF_01875

General rule information [?]

Accession	MF_01875
Dates	23-OCT-2009 (Created) 28-NOV-2023 (Last updated, Version 12)
Name	Prokaryotic_Ku
Scope(s)	Bacteria Archaea Euryarchaeota
Template(s)	O34859 (KU_BACSU); P9WKD9 (KU_MYCTU); A0R3S7 (KU_MYCS2); Q9I1W5 (KU_PSEAE); [ Recover all ]
Triggered by	HAMAP; MF_01875 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	KU
Protein name	RecName: Full=Non-homologous end joining protein Ku;
Gene name	Name=ku;

Comments [?]

FUNCTION	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.
SUBUNIT	Homodimer. Interacts with LigD.
SIMILARITY	Belongs to the prokaryotic Ku family.

Keywords [?]

Gene Ontology [?]

GO:0006281; Biological process:DNA repair

GO:0006974; Biological process:DNA damage response

GO:0006303; Biological process:double-strand break repair via nonhomologous end joining

GO:0003690; Molecular function:double-stranded DNA binding

Cross-references [?]

Features [?]

Additional information [?]

Size range	223-422 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	LigD, the NHEJ partner of Ku, is a multifunctional protein composed of 2-3 domains; polymerase/primase, phosphoesterase and ligase domains. Domain order in LigD is permutated in Actinomycetota and Gammaproteobacteria, whereas the 3 domains are encoded as separate proteins in at least one Euryarchaeota. In Bacilli LigD only has the polymerase/primase and ligase domains.