HAMAP rule MF_01875
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01875 |
| Accession | MF_01875 |
| Dates | 23-OCT-2009 (Created)
08-OCT-2024 (Last updated, Version 14) |
| Name | Prokaryotic_Ku |
| Scope(s) |
Bacteria Archaea Methanobacteriati |
| Template(s) | O34859; P9WKD9; A0R3S7; Q9I1W5; [ Recover all ] |
| Triggered by |
HAMAP; MF_01875 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | KU |
| Protein name | RecName: Full=Non-homologous end joining protein Ku; |
| Gene name | Name=ku; |
Comments
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| FUNCTION | With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. |
| SUBUNIT | Homodimer. Interacts with LigD. |
| SIMILARITY | Belongs to the prokaryotic Ku family. |
Keywords
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Gene Ontology
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| GO:0006281; Biological process:DNA repair |
| GO:0006974; Biological process:DNA damage response |
| GO:0006303; Biological process:double-strand break repair via nonhomologous end joining |
| GO:0003690; Molecular function:double-stranded DNA binding |
Cross-references
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| Pfam | PF02735; Ku; 1; |
| NCBIfam | TIGR02772; Ku_bact; 1; |
| PIRSF | PIRSF006493; Prok_Ku; 1; |
Features
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Additional information
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| Size range | 223-422 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | LigD, the NHEJ partner of Ku, is a multifunctional protein composed of 2-3 domains; polymerase/primase, phosphoesterase and ligase domains. Domain order in LigD is permutated in Actinomycetota and Gammaproteobacteria, whereas the 3 domains are encoded as separate proteins in at least one Euryarchaeota. In Bacilli LigD only has the polymerase/primase and ligase domains. |