Home  |  Contact
Annotation rule MF_01875
Send feedback

General rule information [?]

Accession MF_01875
Dates 23-OCT-2009 (Created)
19-NOV-2019 (Last updated, Version 8)
Name Prokaryotic_Ku
Scope
Bacteria
Archaea; Euryarchaeota
Templates O34859 (KU_BACSU); P9WKD9 (KU_MYCTU); A0R3S7 (KU_MYCS2); Q9I1W5 (KU_PSEAE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KU
Protein name
RecName: Full=Non-homologous end joining protein Ku;
Gene name
ku

Comments [?]

Function With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.
Subunit Homodimer. Interacts with LigD.
Similarity Belongs to the prokaryotic Ku family.

Keywords [?]


Gene Ontology [?]

GO:0006281; Biological process: DNA repair.
GO:0006974; Biological process: cellular response to DNA damage stimulus.
GO:0006303; Biological process: double-strand break repair via nonhomologous end joining.
GO:0003690; Molecular function: double-stranded DNA binding.

Cross-references [?]

Pfam PF02735; Ku; 1; trigger=Yes;
TIGRFAMs TIGR02772; Ku_bact; 1;
PIRSF PIRSF006493; Prok_Ku; 1;

Additional information [?]

Size range 223-422 amino acids
Related rules None
Fusion None
Comments LigD, the NHEJ partner of Ku, is a multifunctional protein composed of 2-3 domains; polymerase/primase, phosphoesterase and ligase domains. Domain order in LigD is permutated in Actinobacteria and Gammaproteobacteria, whereas the 3 domains are encoded as separate proteins in at least one Euryarchaeota. In Bacilli LigD only has the polymerase/primase and ligase domains.