HAMAP rule MF_01884
General rule information
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Accession | MF_01884 |
Dates | 4-AUG-2010 (Created)
1-JUN-2023 (Last updated, Version 14) |
Name | Rho |
Scope(s) |
Bacteria |
Template(s) | P0AG30 (RHO_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01884 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | RHO |
RecName: Full=Transcription termination factor Rho;<br /> EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;<br /> AltName: Full=ATP-dependent helicase Rho; | |
Gene name | Name=rho; |
Comments
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FUNCTION | Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. |
SUBUNIT | Homohexamer. The homohexamer assembles into an open ring structure. |
SIMILARITY | Belongs to the Rho family. |
Keywords
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ATP-binding | |
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a> | |
Hydrolase | |
Nucleotide-binding | |
RNA-binding | |
Transcription | |
Transcription regulation | |
Transcription termination |
Gene Ontology
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GO:0005524; Molecular function:ATP binding |
GO:0004386; Molecular function:helicase activity |
GO:0003723; Molecular function:RNA binding |
GO:0006353; Biological process:DNA-templated transcription termination |
Cross-references
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Pfam | PF00006; ATP-synt_ab; 1; |
Pfam | PF07498; Rho_N; 1; |
Pfam | PF07497; Rho_RNA_bind; 1; |
NCBIfam | TIGR00767; Rho; 1; |
PROSITE | PS51856; RHO_RNA_BD; 1; |
Features
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From: RHO_ECOLI (P0AG30) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 169 | 174 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-x-G-x-x-[GAS] | ||||||||
BINDING | 181 | 186 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[KR]-x-G-K-[TS]-x | ||||||||
REGION | 61 | 66 | /note="RNA-binding 1" | G-[FY]-G-[FYR]-[LV]-R | 1 | |||||||
REGION | 78 | 80 | /note="RNA-binding 1" | D-I-[YFR] | 1 | |||||||
REGION | 108 | 110 | /note="RNA-binding 1" | [ED]-R-[YFR] | 1 | |||||||
REGION | 284 | 288 | /note="RNA-binding 2" | [VL]-L-[TS]-G-G | 1 | |||||||
BINDING | 212 | 212 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
SITE | 326 | 326 | /note="RNA-binding 2" | K | 1 |
Additional information
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Size range | 341-849 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |