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HAMAP rule MF_01884

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General rule information [?]

Accession MF_01884
Dates 4-AUG-2010 (Created)
1-JUN-2023 (Last updated, Version 14)
Name Rho
Scope(s) Bacteria
Template(s) P0AG30 (RHO_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01884 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RHO
RecName: Full=Transcription termination factor Rho;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;<br /> AltName: Full=ATP-dependent helicase Rho;
Gene name Name=rho;

Comments [?]

FUNCTIONFacilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
SUBUNITHomohexamer. The homohexamer assembles into an open ring structure.
SIMILARITYBelongs to the Rho family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0004386; Molecular function:helicase activity
GO:0003723; Molecular function:RNA binding
GO:0006353; Biological process:DNA-templated transcription termination

Cross-references [?]

Pfam PF00006; ATP-synt_ab; 1;
Pfam PF07498; Rho_N; 1;
Pfam PF07497; Rho_RNA_bind; 1;
NCBIfam TIGR00767; Rho; 1;

Features [?]

From: RHO_ECOLI (P0AG30)
Key From To Description Tag Condition FTGroup
BINDING 169 174 /ligand="ATP"
BINDING 181 186 /ligand="ATP"
REGION 61 66 /note="RNA-binding 1" G-[FY]-G-[FYR]-[LV]-R 1
REGION 78 80 /note="RNA-binding 1" D-I-[YFR] 1
REGION 108 110 /note="RNA-binding 1" [ED]-R-[YFR] 1
REGION 284 288 /note="RNA-binding 2" [VL]-L-[TS]-G-G 1
BINDING 212 212 /ligand="ATP"
SITE 326 326 /note="RNA-binding 2" K 1

Additional information [?]

Size range 341-849 amino acids
Related rules None
Fusion Nter: None Cter: None

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