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HAMAP rule MF_01886

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General rule information [?]

Accession MF_01886
Dates 4-NOV-2010 (Created)
19-NOV-2022 (Last updated, Version 12)
Name tRNA_acetyltr_TmcA
Bacteria; Gammaproteobacteria
Templates P76562 (TMCA_ECOLI); D4GW73 (TMCA_HALVD): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=tRNA(Met) cytidine acetyltransferase TmcA;
Gene name

Comments [?]

Function Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
Catalytic activity RHEA:43788: acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate
Subcellular location Cytoplasm.
Similarity Belongs to the TmcA family.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0000049; Molecular function: tRNA binding.
GO:0051392; Molecular function: tRNA N-acetyltransferase activity.
GO:0051391; Biological process: tRNA acetylation.
GO:0002101; Biological process: tRNA wobble cytosine modification.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS51186; GNAT; 1; trigger=PRU00532;
Pfam PF08351; DUF1726; 1;
PF05127; DUF699; 1;
PF00583; Acetyltransf_1; 1;

Features [?]

From: TMCA_ECOLI (P76562)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     174     175       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-A  
BINDING (Optional)     202     211       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-R-G-K-S-A-L-A-G-Q  
BINDING (Optional)     461     463       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288     [IV]-A-[VT]  
BINDING (Optional)     468     474       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288     Q-R-E-G-T-G-R  
BINDING (Optional)     180     180       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     Q  
BINDING (Optional)     319     319       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     R  
BINDING (Optional)     499     499       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288     E  
BINDING (Optional)     506     506       /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288     R  

Additional information [?]

Size range 596-868 amino acids
Related rules None
Fusion None