HAMAP rule MF_01886
General rule information
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| Accession | MF_01886 |
| Dates | 4-NOV-2010 (Created) 19-NOV-2022 (Last updated, Version 12) |
| Name | tRNA_acetyltr_TmcA |
| Scope | Bacteria; Gammaproteobacteria
Archaea |
| Templates | P76562 (TMCA_ECOLI); D4GW73 (TMCA_HALVD): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). |
| Catalytic activity | RHEA:43788: acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate
EC 2.3.1.193 |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the TmcA family. |
Keywords
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Acyltransferase
ATP-binding
Cytoplasm
Nucleotide-binding
RNA-binding
Transferase
tRNA processing
tRNA-binding
ATP-binding
Cytoplasm
Nucleotide-binding
RNA-binding
Transferase
tRNA processing
tRNA-binding
Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0000049; Molecular function: tRNA binding.
GO:0051392; Molecular function: tRNA N-acetyltransferase activity.
GO:0051391; Biological process: tRNA acetylation.
GO:0002101; Biological process: tRNA wobble cytosine modification.
GO:0005737; Cellular component: cytoplasm.
GO:0000049; Molecular function: tRNA binding.
GO:0051392; Molecular function: tRNA N-acetyltransferase activity.
GO:0051391; Biological process: tRNA acetylation.
GO:0002101; Biological process: tRNA wobble cytosine modification.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| PROSITE | PS51186; GNAT; 1; trigger=PRU00532; |
| Pfam | PF08351; DUF1726; 1; |
| PF05127; DUF699; 1; | |
| PF00583; Acetyltransf_1; 1; |
Features
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| From: TMCA_ECOLI (P76562) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 174 | 175 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-A | ||||||||
| BINDING (Optional) | 202 | 211 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | G-R-G-K-S-A-L-A-G-Q | ||||||||
| BINDING (Optional) | 461 | 463 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288 | [IV]-A-[VT] | ||||||||
| BINDING (Optional) | 468 | 474 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288 | Q-R-E-G-T-G-R | ||||||||
| BINDING (Optional) | 180 | 180 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | Q | ||||||||
| BINDING (Optional) | 319 | 319 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | R | ||||||||
| BINDING (Optional) | 499 | 499 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288 | E | ||||||||
| BINDING (Optional) | 506 | 506 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288 | R | ||||||||
Additional information
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| Size range | 596-868 amino acids |
| Related rules | None |
| Fusion | None |