HAMAP rule MF_01886
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01886 |
| Accession | MF_01886 |
| Dates | 04-NOV-2010 (Created)
12-JUN-2025 (Last updated, Version 17) |
| Name | tRNA_acetyltr_TmcA |
| Scope(s) |
Bacteria Gammaproteobacteria Archaea |
| Template(s) | P76562; D4GW73; Q5JHC6; [ Recover all ] |
| Triggered by |
HAMAP; MF_01886 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TMCA |
| Protein name | RecName: Full=tRNA(Met) cytidine acetyltransferase TmcA; EC=2.3.1.193; |
| Gene name | Name=tmcA; |
Comments
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| FUNCTION | Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). |
| case <OC:Thermococcales> | |
| FUNCTION | Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) sites in rRNA, tRNA, mRNA and non-coding (nc)RNA, almost always on the middle C of a CCG motif. In hyperthermophiles more acetylation is seen at higher temperatures. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=cytidine(34) in elongator tRNA(Met) + acetyl-CoA + ATP + H2O = N(4)-acetylcytidine(34) in elongator tRNA(Met) + ADP + phosphate + CoA + H(+); Xref=Rhea:RHEA:43788, Rhea:RHEA-COMP:10693, Rhea:RHEA- COMP:10694, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; EC=2.3.1.193; |
| case <OC:Thermococcales> | |
| CATALYTIC ACTIVITY | Reaction=a cytidine in RNA + acetyl-CoA + ATP + H2O = an N(4)- acetylcytidine in RNA + ADP + phosphate + CoA + H(+); Xref=Rhea:RHEA:82211, Rhea:RHEA-COMP:15704, Rhea:RHEA-COMP:19834, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; |
| CATALYTIC ACTIVITY | Reaction=a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)- acetylcytidine in tRNA + ADP + phosphate + CoA + H(+); Xref=Rhea:RHEA:53876, Rhea:RHEA-COMP:13670, Rhea:RHEA-COMP:13671, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; |
| CATALYTIC ACTIVITY | Reaction=a cytidine in mRNA + acetyl-CoA + ATP + H2O = an N(4)- acetylcytidine in mRNA + ADP + phosphate + CoA + H(+); Xref=Rhea:RHEA:58480, Rhea:RHEA-COMP:15145, Rhea:RHEA-COMP:15146, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456216; |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the TmcA family. |
Keywords
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| Acyltransferase | |
| ATP-binding | |
| Cytoplasm | |
| Nucleotide-binding | |
| case <OC:Thermococcales> | |
| rRNA processing | |
| rRNA-binding | |
| end case | |
| RNA-binding | |
| Transferase | |
| tRNA processing | |
| tRNA-binding | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| GO:0000049; Molecular function:tRNA binding | |
| GO:0051392; Molecular function:tRNA cytidine N4-acetyltransferase activity | |
| GO:0051391; Biological process:tRNA acetylation | |
| GO:0002101; Biological process:tRNA wobble cytosine modification | |
| GO:0005737; Cellular component:cytoplasm | |
| case <OCellular component:Thermococcales> | |
| GO:1990882; Biological process:rRNA acetylation | |
| end case | |
Cross-references
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| PROSITE | PS51186; GNAT; 1; |
| Pfam | PF08351; DUF1726; 1; |
| Pfam | PF05127; DUF699; 1; |
| Pfam | PF00583; Acetyltransf_1; 1; |
Features
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| From: TMCA_ECOLI (P76562) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 174 | 175 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-A | ||||||||
| BINDING | 202 | 211 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-R-G-K-S-A-L-A-G-Q | ||||||||
| BINDING | 461 | 463 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
[IV]-A-[VT] | ||||||||
| BINDING | 468 | 474 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
Q-R-E-G-T-G-R | ||||||||
| BINDING | 180 | 180 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
Q | ||||||||
| BINDING | 319 | 319 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
| BINDING | 499 | 499 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
E | ||||||||
| BINDING | 506 | 506 | /ligand="acetyl-CoA" /ligand_id="ChEBI:CHEBI:57288" |
R | ||||||||
Additional information
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| Size range | 596-868 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |