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HAMAP rule MF_01891

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General rule information [?]

Accession MF_01891
Dates 14-FEB-2011 (Created)
26-JAN-2023 (Last updated, Version 12)
Name FhlC
Scope(s) Bacteria
Template(s) P0ABY7 (FLHC_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01891 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FLHC
Protein name RecName: Full=Flagellar transcriptional regulator FlhC;
Gene name Name=flhC;

Comments [?]

FUNCTIONFunctions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SUBUNITHeterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
SIMILARITYBelongs to the FlhC family.

Keywords [?]

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:1902208; Biological process:regulation of bacterial-type flagellum assembly
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF05280; FlhC; 1;
PIRSF PIRSF003159; FlhC; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 137 137 /ligand="Zn(2+)"
C 1
BINDING 140 140 /ligand="Zn(2+)"
C 1
BINDING 157 157 /ligand="Zn(2+)"
C 1
BINDING 160 160 /ligand="Zn(2+)"
C 1

Additional information [?]

Size range 169-225 amino acids
Related rules None
Fusion Nter: None Cter: None

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