HAMAP rule MF_01891
General rule information
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| Accession | MF_01891 |
| Dates | 14-FEB-2011 (Created)
26-JAN-2023 (Last updated, Version 12) |
| Name | FhlC |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0ABY7 (FLHC_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01891 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FLHC |
| Protein name | RecName: Full=Flagellar transcriptional regulator FlhC; |
| Gene name | Name=flhC; |
Comments
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| FUNCTION | Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways. |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| SUBUNIT | Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the FlhC family. |
Keywords
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| Activator | |
| Bacterial flagellum biogenesis | |
| Cytoplasm | |
| DNA-binding | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
| Transcription | |
| Transcription regulation | |
Gene Ontology
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| GO:0003677; Molecular function:DNA binding | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0006355; Biological process:regulation of DNA-templated transcription | |
| GO:1902208; Biological process:regulation of bacterial-type flagellum assembly | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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| Pfam | PF05280; FlhC; 1; |
| PIRSF | PIRSF003159; FlhC; 1; |
Features
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| From: FLHC_ECOLI (P0ABY7) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 137 | 137 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 140 | 140 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 157 | 157 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 160 | 160 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 169-225 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |