HAMAP rule MF_01892
General rule information
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PURL | https://purl.expasy.org/hamap/rule/MF_01892 |
Accession | MF_01892 |
Dates | 2-MAR-2011 (Created)
2-SEP-2024 (Last updated, Version 7) |
Name | tRNA_Ile2_agm2C_synt |
Scope(s) |
Archaea |
Template(s) | O28025 (TIAS_ARCFU); [ Recover all ] |
Triggered by |
HAMAP; MF_01892 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TIAS |
Protein name | RecName: Full=tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS; Short=tRNA(Ile2)-agm2C synthetase; EC=6.3.4.22; AltName: Full=tRNA(Ile2) agmatidine synthetase; |
Gene name | Name=tiaS; |
Comments
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FUNCTION | ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. |
CATALYTIC ACTIVITY | Reaction=cytidine(34) in tRNA(Ile2) + agmatine + ATP + H2O = 2- agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 phosphate + 2 H(+); Xref=Rhea:RHEA:43608, Rhea:RHEA-COMP:10625, Rhea:RHEA-COMP:10626, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58145, ChEBI:CHEBI:82748, ChEBI:CHEBI:83545, ChEBI:CHEBI:456215; EC=6.3.4.22; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the TiaS family. |
Keywords
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Gene Ontology
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GO:0016879; Molecular function:ligase activity, forming carbon-nitrogen bonds |
GO:0002101; Biological process:tRNA wobble cytosine modification |
Cross-references
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Features
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Additional information
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Size range | 397-508 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |