HAMAP rule MF_01892

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01892
Accession	MF_01892
Dates	02-MAR-2011 (Created) 02-SEP-2024 (Last updated, Version 8)
Name	tRNA_Ile2_agm2C_synt
Scope(s)	Archaea
Template(s)	O28025; [ Recover all ]
Triggered by	HAMAP; MF_01892 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TIAS
Protein name	RecName: Full=tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS; Short=tRNA(Ile2)-agm2C synthetase; EC=6.3.4.22; AltName: Full=tRNA(Ile2) agmatidine synthetase;
Gene name	Name=tiaS;

Comments [?]

FUNCTION	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
CATALYTIC ACTIVITY	Reaction=cytidine(34) in tRNA(Ile2) + agmatine + ATP + H2O = 2- agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 phosphate + 2 H(+); Xref=Rhea:RHEA:43608, Rhea:RHEA-COMP:10625, Rhea:RHEA-COMP:10626, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58145, ChEBI:CHEBI:82748, ChEBI:CHEBI:83545, ChEBI:CHEBI:456215; EC=6.3.4.22;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the TiaS family.

Keywords [?]

Gene Ontology [?]

GO:0016879; Molecular function:ligase activity, forming carbon-nitrogen bonds

GO:0002101; Biological process:tRNA wobble cytosine modification

Cross-references [?]

Pfam	PF08489; DUF1743; 1;
Pfam	PF01336; tRNA_anti; 0-1;

Features [?]

Additional information [?]