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HAMAP rule MF_01909

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General rule information [?]

Accession MF_01909
Dates 29-FEB-2008 (Created)
1-JUN-2023 (Last updated, Version 16)
Name TFE_arch
Scope(s) Archaea
Template(s) Q980M5 (TFE_SACS2); Q8U3H5 (TFE_PYRFU); O27705 (TFE_METTH); Q58187 (TFE_METJA); [ Recover all ]
Triggered by HAMAP; MF_01909 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TFE
Protein name RecName: Full=Transcription factor E;
AltName: Full=TFIIE subunit alpha homolog;
AltName: Full=Transcription initiation factor TFIIE;
Gene name Name=tfe;

Comments [?]

FUNCTIONTranscription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.
SUBUNITMonomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
DOMAINThe winged helix domain is involved in binding to DNA in the preinitiation complex.
SIMILARITYBelongs to the TFE family.

Keywords [?]

Gene Ontology [?]

GO:0006352; Biological process:DNA-templated transcription initiation

Cross-references [?]

Pfam PF02002; TFIIE_alpha; 1;
NCBIfam TIGR00373; TIGR00373; 1;

Features [?]

Additional information [?]

Size range 139-211 amino acids
Related rules None
Fusion Nter: None Cter: None

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