HAMAP rule MF_01916
General rule information
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| Accession | MF_01916 |
| Dates | 15-APR-2014 (Created) 1-JUN-2023 (Last updated, Version 6) |
| Name | Cardiolipin_synth_Cls |
| Scope | Bacteria |
| Template | P71040 (CLSA_BACSU) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
|
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Comments
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| Function | Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. |
| Catalytic activity | RHEA:31451: 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol |
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
| Similarity | Belongs to the phospholipase D family. Cardiolipin synthase subfamily. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Cell membrane
Lipid biosynthesis
Lipid metabolism
Membrane
Phospholipid biosynthesis
Phospholipid metabolism
Transferase
Transmembrane
Transmembrane helix
Lipid biosynthesis
Lipid metabolism
Membrane
Phospholipid biosynthesis
Phospholipid metabolism
Transferase
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0016780; Molecular function: phosphotransferase activity, for other substituted phosphate groups.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| PROSITE | PS50035; PLD; 2; trigger=PRU00153; |
| Pfam | PF13091; PLDc_2; 0-2; |
| PF13396; PLDc_N; 0-1; | |
| PF00614; PLDc; 0-2; | |
| NCBIfam | TIGR04265; bac_cardiolipin; 1; |
Computed features
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| General | Transmembrane; -; 2-3; trigger=yes; |
Features
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| From: CLSA_BACSU (P71040) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 222 | 222 | H | |||||||||
| ACT_SITE | 224 | 224 | K | |||||||||
| ACT_SITE | 229 | 229 | D | |||||||||
| ACT_SITE | 400 | 400 | H | |||||||||
| ACT_SITE | 402 | 402 | K | |||||||||
| ACT_SITE | 407 | 407 | D | |||||||||
Additional information
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| Size range | 440-550 amino acids |
| Related rules | None |
| Fusion | None |