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HAMAP rule MF_01916

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General rule information [?]

Accession MF_01916
Dates 15-APR-2014 (Created)
1-JUN-2023 (Last updated, Version 6)
Name Cardiolipin_synth_Cls
Template P71040 (CLSA_BACSU)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Cardiolipin synthase;
Short=CL synthase;
EC 2.7.8.-;

Comments [?]

Function Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Catalytic activity RHEA:31451: 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the phospholipase D family. Cardiolipin synthase subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0016780; Molecular function: phosphotransferase activity, for other substituted phosphate groups.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS50035; PLD; 2; trigger=PRU00153;
Pfam PF13091; PLDc_2; 0-2;
PF13396; PLDc_N; 0-1;
PF00614; PLDc; 0-2;
NCBIfam TIGR04265; bac_cardiolipin; 1;

Computed features [?]

General Transmembrane; -; 2-3; trigger=yes;

Features [?]

From: CLSA_BACSU (P71040)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     222     222             H  
ACT_SITE     224     224             K  
ACT_SITE     229     229             D  
ACT_SITE     400     400             H  
ACT_SITE     402     402             K  
ACT_SITE     407     407             D  

Additional information [?]

Size range 440-550 amino acids
Related rules None
Fusion None