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HAMAP rule MF_01917

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General rule information [?]

Accession MF_01917
Dates 16-APR-2014 (Created)
26-JAN-2023 (Last updated, Version 6)
Name Cardiolipin_synth_ClsB
Scope(s) Bacteria
Template(s) P0AA84 (CLSB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01917 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CLSB
Protein name RecName: Full=Cardiolipin synthase B;
                 Short=CL synthase;
Gene name Name=clsB;

Comments [?]

FUNCTIONCatalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
CATALYTIC ACTIVITY Reaction=2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716;
SUBCELLULAR LOCATIONCell membrane; Peripheral membrane protein.
SIMILARITYBelongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups
GO:0008654; Biological process:phospholipid biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

PROSITE PS50035; PLD; 2;
Pfam PF13091; PLDc_2; 2;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 113 113 H
ACT_SITE 115 115 K
ACT_SITE 120 120 D
ACT_SITE 290 290 H
ACT_SITE 292 292 K
ACT_SITE 297 297 D

Additional information [?]

Size range 370-460 amino acids
Related rules None
Fusion Nter: None Cter: None

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