HAMAP rule MF_01917
General rule information
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| Accession | MF_01917 |
| Dates | 16-APR-2014 (Created)
26-JAN-2023 (Last updated, Version 6) |
| Name | Cardiolipin_synth_ClsB |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P0AA84 (CLSB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01917 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CLSB |
| Protein name | RecName: Full=Cardiolipin synthase B; Short=CL synthase; EC=2.7.8.-; |
| Gene name | Name=clsB; |
Comments
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| FUNCTION | Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. |
| CATALYTIC ACTIVITY | Reaction=2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol; Xref=Rhea:RHEA:31451, ChEBI:CHEBI:17754, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716; |
| SUBCELLULAR LOCATION | Cell membrane; Peripheral membrane protein. |
| SIMILARITY | Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily. |
Keywords
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| Cell membrane |
| Lipid biosynthesis |
| Lipid metabolism |
| Membrane |
| Phospholipid biosynthesis |
| Phospholipid metabolism |
| Transferase |
Gene Ontology
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| GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups |
| GO:0008654; Biological process:phospholipid biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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Features
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| From: CLSB_ECOLI (P0AA84) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 113 | 113 | H | |||||||||
| ACT_SITE | 115 | 115 | K | |||||||||
| ACT_SITE | 120 | 120 | D | |||||||||
| ACT_SITE | 290 | 290 | H | |||||||||
| ACT_SITE | 292 | 292 | K | |||||||||
| ACT_SITE | 297 | 297 | D | |||||||||
Additional information
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| Size range | 370-460 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |