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HAMAP rule MF_01917

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General rule information [?]

Accession MF_01917
Dates 16-APR-2014 (Created)
26-JAN-2023 (Last updated, Version 6)
Name Cardiolipin_synth_ClsB
Bacteria; Pseudomonadota
Template P0AA84 (CLSB_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Cardiolipin synthase B;
Short=CL synthase;
EC 2.7.8.-;
Gene name

Comments [?]

Function Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
Catalytic activity RHEA:31451: 2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol
Subcellular location Cell membrane; Peripheral membrane protein.
Similarity Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsB sub-subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016780; Molecular function: phosphotransferase activity, for other substituted phosphate groups.
GO:0008654; Biological process: phospholipid biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

PROSITE PS50035; PLD; 2; trigger=PRU00153;
Pfam PF13091; PLDc_2; 2;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     113     113             H  
ACT_SITE     115     115             K  
ACT_SITE     120     120             D  
ACT_SITE     290     290             H  
ACT_SITE     292     292             K  
ACT_SITE     297     297             D  

Additional information [?]

Size range 370-460 amino acids
Related rules None
Fusion None