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Annotation rule MF_01921 |
General rule information
[?]
Accession |
MF_01921 |
Dates |
13-MAY-2014 (Created) 19-NOV-2019 (Last updated, Version 5) |
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase;
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EC 4.1.3.44;
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AltName:
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Full=tRNA wyosine derivatives biosynthesis protein Taw1;
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Function |
Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). |
Catalytic activity |
RHEA:36347: N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine
EC 4.1.3.44
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case <FTGroup:1>
Cofactor |
[4Fe-4S] cluster Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. |
end case
Subunit |
Monomer. |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the TYW1 family. |
case <FTGroup:1>
end case
case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
end case
From: TYW1_METJA (Q57705) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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METAL
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26
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26
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Iron-sulfur 1 (4Fe-4S)
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C
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1
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METAL
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39
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39
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Iron-sulfur 1 (4Fe-4S)
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C
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1
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METAL
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52
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52
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Iron-sulfur 1 (4Fe-4S)
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C
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1
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METAL
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62
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62
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Iron-sulfur 2 (4Fe-4S-S-AdoMet)
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C
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1
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METAL
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66
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66
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Iron-sulfur 2 (4Fe-4S-S-AdoMet)
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C
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1
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METAL
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69
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69
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Iron-sulfur 2 (4Fe-4S-S-AdoMet)
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C
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1
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Additional information
[?]
Size range |
288-386 amino acids |
Related rules |
None |
Fusion |
None |