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Annotation rule MF_01921
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General rule information [?]

Accession MF_01921
Dates 13-MAY-2014 (Created)
19-NOV-2019 (Last updated, Version 5)
Name TYW1_archaea
Scope
Archaea
Templates Q57705 (TYW1_METJA); Q9V1F9 (TYW1_PYRAB); O59412 (TYW1_PYRHO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TYW1
Protein name
RecName: Full=S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase;
EC 4.1.3.44;
AltName: Full=tRNA wyosine derivatives biosynthesis protein Taw1;
Gene name
taw1

Comments [?]

Function Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
Catalytic activity RHEA:36347: N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine
EC 4.1.3.44
case <FTGroup:1>
Cofactor [4Fe-4S] cluster
Note: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
end case
Subunit Monomer.
Subcellular location Cytoplasm.
Similarity Belongs to the TYW1 family.

Keywords [?]

case <FTGroup:1>
4Fe-4S
Iron
Iron-sulfur
Metal-binding
end case
Cytoplasm
Lyase
S-adenosyl-L-methionine
tRNA processing

Gene Ontology [?]

case <FTGroup:1>
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
end case
GO:0016833; Molecular function: oxo-acid-lyase activity.
GO:0008033; Biological process: tRNA processing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF04055; Radical_SAM; 1;
PF08608; Wyosine_form; 1;
TIGRFAMs TIGR03972; rSAM_TYW1; 1;

Features [?]

From: TYW1_METJA (Q57705)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     26     26       Iron-sulfur 1 (4Fe-4S)     C   1
METAL     39     39       Iron-sulfur 1 (4Fe-4S)     C   1
METAL     52     52       Iron-sulfur 1 (4Fe-4S)     C   1
METAL     62     62       Iron-sulfur 2 (4Fe-4S-S-AdoMet)     C   1
METAL     66     66       Iron-sulfur 2 (4Fe-4S-S-AdoMet)     C   1
METAL     69     69       Iron-sulfur 2 (4Fe-4S-S-AdoMet)     C   1

Additional information [?]

Size range 288-386 amino acids
Related rules None
Fusion None


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