HAMAP rule MF_01921
General rule information
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| Accession | MF_01921 |
| Dates | 13-MAY-2014 (Created)
1-JUN-2023 (Last updated, Version 9) |
| Name | TYW1_archaea |
| Scope(s) |
Archaea |
| Template(s) | Q57705 (TYW1_METJA); Q9V1F9 (TYW1_PYRAB); O59412 (TYW1_PYRHO); [ Recover all ] |
| Triggered by |
HAMAP; MF_01921 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TYW1 |
| Protein name | RecName: Full=S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; EC=4.1.3.44; AltName: Full=tRNA wyosine derivatives biosynthesis protein Taw1; |
| Gene name | Name=taw1; |
Comments
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| FUNCTION | Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). |
| CATALYTIC ACTIVITY | Reaction=N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl- L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine; Xref=Rhea:RHEA:36347, Rhea:RHEA- COMP:10164, Rhea:RHEA-COMP:10165, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377, ChEBI:CHEBI:16526, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:59789, ChEBI:CHEBI:64315, ChEBI:CHEBI:73542; EC=4.1.3.44; |
| case <FTGroup:1> | |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.; |
| end case | |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the TYW1 family. |
Keywords
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| case <FTGroup:1> | |
| 4Fe-4S | |
| Iron | |
| Iron-sulfur | |
| Metal-binding | |
| end case | |
| Cytoplasm | |
| Lyase | |
| S-adenosyl-L-methionine | |
| tRNA processing | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding | |
| end case | |
| GO:0016833; Molecular function:oxo-acid-lyase activity | |
| GO:0008033; Biological process:tRNA processing | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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| From: TYW1_METJA (Q57705) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 26 | 26 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1" |
C | 1 | |||||||
| BINDING | 39 | 39 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1" |
C | 1 | |||||||
| BINDING | 52 | 52 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="1" |
C | 1 | |||||||
| BINDING | 62 | 62 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
| BINDING | 66 | 66 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
| BINDING | 69 | 69 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_label="2" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
Additional information
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| Size range | 288-386 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |