HAMAP rule MF_01922
General rule information
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Accession | MF_01922 |
Dates | 14-MAY-2014 (Created) 19-NOV-2022 (Last updated, Version 7) |
Name | TYW2_archaea |
Scope | Archaea |
Templates | Q58952 (TYW2_METJA); O58523 (TYW2_PYRHO): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). |
Catalytic activity | RHEA:36355: 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
EC 2.5.1.114 |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. |
Keywords
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Gene Ontology
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GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0008033; Biological process: tRNA processing.
GO:0005737; Cellular component: cytoplasm.
GO:0008033; Biological process: tRNA processing.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: TYW2_METJA (Q58952) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 154 | 155 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [DE]-N | ||||||||
BINDING | 80 | 80 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [SA] | ||||||||
BINDING | 87 | 87 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [RK] | ||||||||
BINDING | 127 | 127 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | E |
Additional information
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Size range | 240-442 amino acids |
Related rules | None |
Fusion | None |