HAMAP rule MF_01922

General rule information [?]

Accession	MF_01922
Dates	14-MAY-2014 (Created) 19-NOV-2022 (Last updated, Version 7)
Name	TYW2_archaea
Scope(s)	Archaea
Template(s)	Q58952 (TYW2_METJA); O58523 (TYW2_PYRHO); [ Recover all ]
Triggered by	HAMAP; MF_01922 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	TYW2
Protein name	RecName: Full=tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; EC=2.5.1.114; AltName: Full=tRNA wyosine derivatives biosynthesis protein Taw2;
Gene name	Name=taw2;

Comments [?]

FUNCTION	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).
CATALYTIC ACTIVITY	Reaction=4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine; Xref=Rhea:RHEA:36355, Rhea:RHEA- COMP:10164, Rhea:RHEA-COMP:10378, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:64315, ChEBI:CHEBI:73550; EC=2.5.1.114;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

Keywords [?]

Gene Ontology [?]

GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups

GO:0008033; Biological process:tRNA processing

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

PROSITE	PS51684; SAM_MT_TRM5_TYW2; 1;
Pfam	PF02475; Met_10; 1;

Features [?]

From: TYW2_METJA (Q58952)

Key

From

Description

Tag

Condition

FTGroup

BINDING

154

155

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

[DE]-N

BINDING

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

[SA]

BINDING

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

[RK]

BINDING

127

/ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"

Additional information [?]