HAMAP rule MF_01922
General rule information
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Accession | MF_01922 |
Dates | 14-MAY-2014 (Created)
19-NOV-2022 (Last updated, Version 7) |
Name | TYW2_archaea |
Scope(s) |
Archaea |
Template(s) | Q58952 (TYW2_METJA); O58523 (TYW2_PYRHO); [ Recover all ] |
Triggered by |
HAMAP; MF_01922 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TYW2 |
Protein name | RecName: Full=tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; EC=2.5.1.114; AltName: Full=tRNA wyosine derivatives biosynthesis protein Taw2; |
Gene name | Name=taw2; |
Comments
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FUNCTION | S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). |
CATALYTIC ACTIVITY | Reaction=4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine; Xref=Rhea:RHEA:36355, Rhea:RHEA- COMP:10164, Rhea:RHEA-COMP:10378, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:64315, ChEBI:CHEBI:73550; EC=2.5.1.114; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. |
Keywords
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Gene Ontology
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GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups |
GO:0008033; Biological process:tRNA processing |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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From: TYW2_METJA (Q58952) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 154 | 155 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[DE]-N | ||||||||
BINDING | 80 | 80 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[SA] | ||||||||
BINDING | 87 | 87 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[RK] | ||||||||
BINDING | 127 | 127 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
E |
Additional information
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Size range | 240-442 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |