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HAMAP rule MF_01922

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General rule information [?]

Accession MF_01922
Dates 14-MAY-2014 (Created)
19-NOV-2022 (Last updated, Version 7)
Name TYW2_archaea
Scope
Archaea
Templates Q58952 (TYW2_METJA); O58523 (TYW2_PYRHO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TYW2
Protein name
RecName: Full=tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase;
EC 2.5.1.114;
AltName: Full=tRNA wyosine derivatives biosynthesis protein Taw2;
Gene name
taw2

Comments [?]

Function S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).
Catalytic activity RHEA:36355: 4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-methyl-5'-thioadenosine
EC 2.5.1.114
Subcellular location Cytoplasm.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.

Keywords [?]

Cytoplasm
S-adenosyl-L-methionine
Transferase
tRNA processing

Gene Ontology [?]

GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0008033; Biological process: tRNA processing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS51684; SAM_MT_TRM5_TYW2; 1;
Pfam PF02475; Met_10; 1;

Features [?]

From: TYW2_METJA (Q58952)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     154     155       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [DE]-N  
BINDING     80     80       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [SA]  
BINDING     87     87       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [RK]  
BINDING     127     127       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     E  

Additional information [?]

Size range 240-442 amino acids
Related rules None
Fusion None


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