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HAMAP rule MF_01924

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General rule information [?]

Accession MF_01924
Dates 13-JUN-2014 (Created)
26-JAN-2023 (Last updated, Version 8)
Name A_A_dipeptidase
Scope(s) Bacteria
Template(s) Q06241 (VANX_ENTFC); P77790 (DDPX_ECOLI); P74268 (DDPX_SYNY3); Q9XAK6 (VANX_STRCO); [ Recover all ]
Triggered by HAMAP; MF_01924 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DDPX
Protein name RecName: Full=D-alanyl-D-alanine dipeptidase;
                 Short=D-Ala-D-Ala dipeptidase;
case <OC:Pseudomonadota>
Gene name Name=ddpX;
end case

Comments [?]

FUNCTIONCatalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
CATALYTIC ACTIVITY Reaction=D-alanyl-D-alanine + H2O = 2 D-alanine; Xref=Rhea:RHEA:20661, ChEBI:CHEBI:15377, ChEBI:CHEBI:57416, ChEBI:CHEBI:57822; EC=;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SIMILARITYBelongs to the peptidase M15D family.

Keywords [?]

Gene Ontology [?]

GO:0016805; Molecular function:dipeptidase activity
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Pfam PF01427; Peptidase_M15; 1;
PIRSF PIRSF026671; AA_dipeptidase; 1;

Features [?]

From: VANX_ENTFC (Q06241)
Key From To Description Tag Condition FTGroup
ACT_SITE 181 181 /note="Proton donor/acceptor" E
BINDING 116 116 /ligand="Zn(2+)"
H 1
BINDING 123 123 /ligand="Zn(2+)"
D 1
BINDING 184 184 /ligand="Zn(2+)"
H 1
SITE 71 71 /note="Transition state stabilizer" R

Additional information [?]

Size range 169-330 amino acids
Related rules None
Fusion Nter: None Cter: None

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