HAMAP rule MF_01924
General rule information
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| Accession | MF_01924 |
| Dates | 13-JUN-2014 (Created) 26-JAN-2023 (Last updated, Version 8) |
| Name | A_A_dipeptidase |
| Scope | Bacteria |
| Templates | Q06241 (VANX_ENTFC); P77790 (DDPX_ECOLI); P74268 (DDPX_SYNY3); Q9XAK6 (VANX_STRCO): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
| Protein name |
|
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case <OC:Pseudomonadota>
| Gene name |
|
end case
Comments
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| Function | Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. |
| Catalytic activity | RHEA:20661: D-alanyl-D-alanine + H2O = 2 D-alanine
EC 3.4.13.22 |
case <FTGroup:1>
| Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
| Similarity | Belongs to the peptidase M15D family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0016805; Molecular function: dipeptidase activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
Cross-references
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| Pfam | PF01427; Peptidase_M15; 1; |
| PIRSF | PIRSF026671; AA_dipeptidase; 1; |
Features
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| From: VANX_ENTFC (Q06241) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 181 | 181 | Proton donor/acceptor | E | ||||||||
| BINDING | 116 | 116 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
| BINDING | 123 | 123 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | D | 1 | |||||||
| BINDING | 184 | 184 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
| SITE | 71 | 71 | Transition state stabilizer | R | ||||||||
Additional information
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| Size range | 169-330 amino acids |
| Related rules | None |
| Fusion | None |