HAMAP rule MF_01924

General rule information [?]

Accession	MF_01924
Dates	13-JUN-2014 (Created) 26-JAN-2023 (Last updated, Version 8)
Name	A_A_dipeptidase
Scope(s)	Bacteria
Template(s)	Q06241 (VANX_ENTFC); P77790 (DDPX_ECOLI); P74268 (DDPX_SYNY3); Q9XAK6 (VANX_STRCO); [ Recover all ]
Triggered by	HAMAP; MF_01924 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DDPX
Protein name	RecName: Full=D-alanyl-D-alanine dipeptidase; Short=D-Ala-D-Ala dipeptidase; EC=3.4.13.22;
case <OC:Pseudomonadota>
Gene name	Name=ddpX;
end case

Comments [?]

FUNCTION	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
CATALYTIC ACTIVITY	Reaction=D-alanyl-D-alanine + H2O = 2 D-alanine; Xref=Rhea:RHEA:20661, ChEBI:CHEBI:15377, ChEBI:CHEBI:57416, ChEBI:CHEBI:57822; EC=3.4.13.22;
case <FTGroup:1>
COFACTOR	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
SIMILARITY	Belongs to the peptidase M15D family.

Keywords [?]

Gene Ontology [?]

GO:0016805; Molecular function:dipeptidase activity
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case

Cross-references [?]

Pfam	PF01427; Peptidase_M15; 1;
PIRSF	PIRSF026671; AA_dipeptidase; 1;

Features [?]

From: VANX_ENTFC (Q06241)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

181

/note="Proton donor/acceptor"

BINDING

116

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"

BINDING

123

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"

BINDING

184

/ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"

SITE

/note="Transition state stabilizer"

Additional information [?]