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HAMAP rule MF_01924

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General rule information [?]

Accession MF_01924
Dates 13-JUN-2014 (Created)
26-JAN-2023 (Last updated, Version 8)
Name A_A_dipeptidase
Templates Q06241 (VANX_ENTFC); P77790 (DDPX_ECOLI); P74268 (DDPX_SYNY3); Q9XAK6 (VANX_STRCO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=D-alanyl-D-alanine dipeptidase;
Short=D-Ala-D-Ala dipeptidase;
case <OC:Pseudomonadota>
Gene name
end case

Comments [?]

Function Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
Catalytic activity RHEA:20661: D-alanyl-D-alanine + H2O = 2 D-alanine
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Similarity Belongs to the peptidase M15D family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0016805; Molecular function: dipeptidase activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case

Cross-references [?]

Pfam PF01427; Peptidase_M15; 1;
PIRSF PIRSF026671; AA_dipeptidase; 1;

Features [?]

From: VANX_ENTFC (Q06241)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     181     181       Proton donor/acceptor     E  
BINDING     116     116       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     123     123       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     D   1
BINDING     184     184       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
SITE     71     71       Transition state stabilizer     R  

Additional information [?]

Size range 169-330 amino acids
Related rules None
Fusion None