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HAMAP rule MF_01927

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General rule information [?]

Accession MF_01927
Dates 10-JUL-2014 (Created)
18-JUL-2023 (Last updated, Version 6)
Name PurU
Scope(s) Bacteria
Template(s) P37051 (PURU_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01927 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PURU
Protein name RecName: Full=Formyltetrahydrofolate deformylase;
                 EC=3.5.1.10;
AltName: Full=Formyl-FH(4) hydrolase;
Gene name Name=purU;

Comments [?]

FUNCTIONCatalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
CATALYTIC ACTIVITY Reaction=(6R)-10-formyltetrahydrofolate + H2O = (6S)-5,6,7,8- tetrahydrofolate + formate + H(+); Xref=Rhea:RHEA:19833, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:57453, ChEBI:CHEBI:195366; EC=3.5.1.10;
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; formate from 10-formyl-5,6,7,8-tetrahydrofolate: step 1/1.
SIMILARITYBelongs to the PurU family.

Keywords [?]


Gene Ontology [?]

GO:0008864; Molecular function:formyltetrahydrofolate deformylase activity
GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

PROSITE PS51671; ACT; 1;
Pfam PF01842; ACT; 1;
Pfam PF00551; Formyl_trans_N; 1;
PRINTS PR01575; FFH4HYDRLASE; 1;
NCBIfam TIGR00655; PurU; 1;
PIRSF PIRSF036480; FormyFH4_hydr; 1;

Features [?]

From: PURU_ECOLI (P37051)
Key From To Description Tag Condition FTGroup
ACT_SITE 225 225 D

Additional information [?]

Size range 230-340 amino acids
Related rules None
Fusion Nter: None Cter: None



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