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HAMAP rule MF_01928

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General rule information [?]

Accession MF_01928
Dates 21-AUG-2014 (Created)
1-JUN-2023 (Last updated, Version 8)
Name PurK
Scope(s) Bacteria
Template(s) P09029 (PURK_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01928 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PURK
Protein name RecName: Full=N5-carboxyaminoimidazole ribonucleotide synthase;
                 Short=N5-CAIR synthase;
AltName: Full=5-(carboxyamino)imidazole ribonucleotide synthetase;
Gene name Name=purK;

Comments [?]

FUNCTIONCatalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
CATALYTIC ACTIVITY Reaction=5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate; Xref=Rhea:RHEA:19317, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58730, ChEBI:CHEBI:137981, ChEBI:CHEBI:456216; EC=;
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5- phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.
SIMILARITYBelongs to the PurK/PurT family.

Keywords [?]

Gene Ontology [?]

GO:0034028; Molecular function:5-(carboxyamino)imidazole ribonucleotide synthase activity
GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Pfam PF02222; ATP-grasp; 1;
NCBIfam TIGR01161; purK; 1;

Features [?]

From: PURK_ECOLI (P09029)
Key From To Description Tag Condition FTGroup
case <Feature:PS50975>
DOMAIN 84 267 /note="ATP-grasp"
end case
BINDING 125 131 /ligand="ATP"
BINDING 153 156 /ligand="ATP"
BINDING 237 238 /ligand="ATP"
BINDING 80 80 /ligand="ATP"
BINDING 120 120 /ligand="ATP"
BINDING 161 161 /ligand="ATP"
BINDING 184 184 /ligand="ATP"

Additional information [?]

Size range 335-460 amino acids
Related rules None
Fusion Nter: None Cter: None

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