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HAMAP rule MF_01928

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General rule information [?]

Accession MF_01928
Dates 21-AUG-2014 (Created)
19-NOV-2022 (Last updated, Version 7)
Name PurK
Scope
Bacteria
Archaea
Template P09029 (PURK_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PURK
Protein name
RecName: Full=N5-carboxyaminoimidazole ribonucleotide synthase;
Short=N5-CAIR synthase;
EC 6.3.4.18;
AltName: Full=5-(carboxyamino)imidazole ribonucleotide synthetase;
Gene name
purK

Comments [?]

Function Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Catalytic activity RHEA:19317: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate
EC 6.3.4.18
Pathway Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.
Subunit Homodimer.
Similarity Belongs to the PurK/PurT family.

Keywords [?]

ATP-binding
Ligase
Nucleotide-binding
Purine biosynthesis

Gene Ontology [?]

GO:0034028; Molecular function: 5-(carboxyamino)imidazole ribonucleotide synthase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

PROSITE PS50975; ATP_GRASP; 1;
Pfam PF02222; ATP-grasp; 1;
TIGRFAMs TIGR01161; purK; 1;

Features [?]

case <Feature:PS50975>
From: PURK_ECOLI (P09029)
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     84     267       ATP-grasp        
end case
BINDING (Optional)     125     131       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [GA]-Y-D-G-x-G-Q  
BINDING (Optional)     153     156       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [EQD]-x-x-[IVL]  
BINDING (Optional)     237     238       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     N-E  
BINDING (Optional)     80     80       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [RK]  
BINDING (Optional)     120     120       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     K  
BINDING (Optional)     161     161       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     E  
BINDING (Optional)     184     184       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     H  

Additional information [?]

Size range 335-460 amino acids
Related rules None
Fusion None


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