HAMAP rule MF_01928
General rule information
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Accession | MF_01928 |
Dates | 21-AUG-2014 (Created) 19-NOV-2022 (Last updated, Version 7) |
Name | PurK |
Scope | Bacteria
Archaea |
Template | P09029 (PURK_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). |
Catalytic activity | RHEA:19317: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate
EC 6.3.4.18 |
Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2. |
Subunit | Homodimer. |
Similarity | Belongs to the PurK/PurT family. |
Keywords
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Gene Ontology
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GO:0034028; Molecular function: 5-(carboxyamino)imidazole ribonucleotide synthase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.
Cross-references
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Features
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case <Feature:PS50975>
From: PURK_ECOLI (P09029) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | 84 | 267 | ATP-grasp |
end case
Additional information
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Size range | 335-460 amino acids |
Related rules | None |
Fusion | None |