HAMAP rule MF_01929
General rule information
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Accession | MF_01929 |
Dates | 25-AUG-2014 (Created) 14-MAY-2022 (Last updated, Version 6) |
Name | PurE_classI |
Scope | Bacteria
Archaea |
Template | P0AG18 (PURE_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). |
Catalytic activity | RHEA:13193: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
EC 5.4.99.18 |
Pathway | Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2. |
Similarity | Belongs to the AIR carboxylase family. Class I subfamily. |
Keywords
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Gene Ontology
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GO:0034023; Molecular function: 5-(carboxyamino)imidazole ribonucleotide mutase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.
Cross-references
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Pfam | PF00731; AIRC; 1; |
TIGRFAMs | TIGR01162; purE; 1; |
PIRSF | PIRSF001338; AIR_carboxylase; 1; |
Features
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From: PURE_ECOLI (P0AG18) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 16 | 16 | /ligand="substrate | S | ||||||||
BINDING | 19 | 19 | /ligand="substrate | D | ||||||||
BINDING | 46 | 46 | /ligand="substrate | R |
Additional information
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Size range | 157-339 amino acids |
Related rules | None |
Fusion | None |
Comments | See rule MF_02045 for prokaryotic class II PurEs. Class I and class II PurEs are mechanistically related but bind different substrates. |