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HAMAP rule MF_01929

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General rule information [?]

Accession MF_01929
Dates 25-AUG-2014 (Created)
1-JUN-2023 (Last updated, Version 7)
Name PurE_classI
Scope(s) Bacteria
Template(s) P0AG18 (PURE_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01929 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PURE
Protein name RecName: Full=N5-carboxyaminoimidazole ribonucleotide mutase;
                 Short=N5-CAIR mutase;
AltName: Full=5-(carboxyamino)imidazole ribonucleotide mutase;
Gene name Name=purE;

Comments [?]

FUNCTIONCatalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
CATALYTIC ACTIVITY Reaction=5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate; Xref=Rhea:RHEA:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:58730, ChEBI:CHEBI:77657; EC=;
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; 5- amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5- phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
SIMILARITYBelongs to the AIR carboxylase family. Class I subfamily.

Keywords [?]

Gene Ontology [?]

GO:0034023; Molecular function:5-(carboxyamino)imidazole ribonucleotide mutase activity
GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Pfam PF00731; AIRC; 1;
NCBIfam TIGR01162; purE; 1;
PIRSF PIRSF001338; AIR_carboxylase; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 16 16 /ligand="substrate" S
BINDING 19 19 /ligand="substrate" D
BINDING 46 46 /ligand="substrate" R

Additional information [?]

Size range 157-339 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments See rule MF_02045 for prokaryotic class II PurEs. Class I and class II PurEs are mechanistically related but bind different substrates.

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