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Annotation rule MF_01929
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General rule information [?]

Accession MF_01929
Dates 25-AUG-2014 (Created)
19-NOV-2019 (Last updated, Version 5)
Name PurE_classI
Scope
Bacteria
Archaea
Template P0AG18 (PURE_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PURE
Protein name
RecName: Full=N5-carboxyaminoimidazole ribonucleotide mutase;
Short=N5-CAIR mutase;
EC 5.4.99.18;
AltName: Full=5-(carboxyamino)imidazole ribonucleotide mutase;
Gene name
purE

Comments [?]

Function Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
Catalytic activity RHEA:13193: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
EC 5.4.99.18
Pathway Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
Similarity Belongs to the AIR carboxylase family. Class I subfamily.

Keywords [?]


Gene Ontology [?]

GO:0034023; Molecular function: 5-(carboxyamino)imidazole ribonucleotide mutase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

Pfam PF00731; AIRC; 1;
TIGRFAMs TIGR01162; purE; 1;
PIRSF PIRSF001338; AIR_carboxylase; 1;

Features [?]

From: PURE_ECOLI (P0AG18)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     16     16       Substrate     S  
BINDING     19     19       Substrate     D  
BINDING     46     46       Substrate     R  

Additional information [?]

Size range 157-339 amino acids
Related rules None
Fusion None
Comments See rule MF_02045 for prokaryotic class II PurEs. Class I and class II PurEs are mechanistically related but bind different substrates.