HAMAP rule MF_01929

General rule information [?]

Accession	MF_01929
Dates	25-AUG-2014 (Created) 14-MAY-2022 (Last updated, Version 6)

Name	PurE_classI

Scope

Bacteria

Archaea

Template

P0AG18 (PURE_ECOLI)

Triggered by

HAMAP; MF_01929 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PURE

Protein name

RecName:		Full=N5-carboxyaminoimidazole ribonucleotide mutase;
		Short=N5-CAIR mutase;
		EC 5.4.99.18;
AltName:		Full=5-(carboxyamino)imidazole ribonucleotide mutase;

Gene name

purE

Comments [?]

Function	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
Catalytic activity	RHEA:13193: 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate EC 5.4.99.18
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
Similarity	Belongs to the AIR carboxylase family. Class I subfamily.

Keywords [?]

Isomerase
Purine biosynthesis

Gene Ontology [?]

GO:0034023; Molecular function: 5-(carboxyamino)imidazole ribonucleotide mutase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

Pfam	PF00731; AIRC; 1;
TIGRFAMs	TIGR01162; purE; 1;
PIRSF	PIRSF001338; AIR_carboxylase; 1;

Features [?]

From: PURE_ECOLI (P0AG18)

Key From To Description Tag Condition FTGroup

BINDING 16 16 /ligand="substrate S

BINDING 19 19 /ligand="substrate D

BINDING 46 46 /ligand="substrate R

Additional information [?]

Size range	157-339 amino acids
Related rules	None
Fusion	None
Comments	See rule MF_02045 for prokaryotic class II PurEs. Class I and class II PurEs are mechanistically related but bind different substrates.

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