HAMAP rule MF_01930

General rule information [?]

Accession	MF_01930
Dates	1-SEP-2014 (Created) 1-JUN-2023 (Last updated, Version 9)

Name

PurN

Scope

Bacteria

Template

P08179 (PUR3_ECOLI)

Triggered by

HAMAP; MF_01930 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

PUR3

Protein name

RecName:		Full=Phosphoribosylglycinamide formyltransferase;
		EC 2.1.2.2;
AltName:		Full=5'-phosphoribosylglycinamide transformylase;
AltName:		Full=GAR transformylase;
		Short=GART;

Gene name

purN

Comments [?]

Function	Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
Catalytic activity	RHEA:15053: (6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide EC 2.1.2.2
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.
Similarity	Belongs to the GART family.

Keywords [?]

Purine biosynthesis
Transferase

Gene Ontology [?]

GO:0004644; Molecular function: phosphoribosylglycinamide formyltransferase activity.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

PROSITE	PS00373; GART; 1;
Pfam	PF00551; Formyl_trans_N; 1;
NCBIfam	TIGR00639; PurN; 1;

Features [?]

From: PUR3_ECOLI (P08179)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 11 13 /ligand="N(1)-(5-phospho-beta-D-ribosyl)glycinamide" /ligand_id="ChEBI:CHEBI:143788 G-[ST]-N

BINDING (Optional) 89 92 /ligand="(6S)-10-formyltetrahydrofolate" /ligand_id="ChEBI:CHEBI:57454 [MLF]-[RK]-[IL]-[LVI]

ACT_SITE 108 108 Proton donor H

BINDING (Optional) 64 64 /ligand="(6S)-10-formyltetrahydrofolate" /ligand_id="ChEBI:CHEBI:57454 [RK]

BINDING (Optional) 106 106 /ligand="(6S)-10-formyltetrahydrofolate" /ligand_id="ChEBI:CHEBI:57454 N

SITE (Optional) 144 144 Raises pKa of active site His D

Additional information [?]

Size range	169-270 amino acids
Related rules	None
Fusion	None

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