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HAMAP rule MF_01933

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General rule information [?]

Accession MF_01933
Dates 6-OCT-2014 (Created)
1-JUN-2023 (Last updated, Version 10)
Name MenC_2
Scope
Bacteria
Archaea
Templates O34514 (MENC_BACSU); P29208 (MENC_ECOLI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MENC
Protein name
RecName: Full=o-succinylbenzoate synthase;
Short=OSB synthase;
Short=OSBS;
EC 4.2.1.113;
AltName: Full=4-(2'-carboxyphenyl)-4-oxybutyric acid synthase;
AltName: Full=o-succinylbenzoic acid synthase;
Gene name
menC

Comments [?]

Function Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
Catalytic activity RHEA:10196: (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O
EC 4.2.1.113
Cofactor a divalent metal cation
Pathway Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.
case not <OC:Cyanobacteriota>
Pathway Quinol/quinone metabolism; menaquinone biosynthesis.
else case <OC:Cyanobacteriota>
Pathway Cofactor biosynthesis; phylloquinone biosynthesis.
end case
Similarity Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.

Keywords [?]

case not <OC:Cyanobacteriota>
Menaquinone biosynthesis
end case
Lyase
case <FTGroup:1>
Magnesium
Metal-binding
end case

Gene Ontology [?]

GO:0016836; Molecular function: hydro-lyase activity.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
case not <OC:Cyanobacteriota>
GO:0009234; Biological process: menaquinone biosynthetic process.
else case <OC:Cyanobacteriota>
GO:0042372; Biological process: phylloquinone biosynthetic process.
end case

Cross-references [?]

Pfam PF02746; MR_MLE_N; 1;
PF01188; MR_MLE; 0-1;
NCBIfam TIGR01928; menC_lowGC/arch; 1;

Features [?]

From: MENC_BACSU (O34514)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     164     164       Proton donor     K  
ACT_SITE     263     263       Proton acceptor     K  
BINDING     189     189       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D   1
BINDING     214     214       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E   1
BINDING     239     239       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D   1

Additional information [?]

Size range 328-400 amino acids
Related rules None
Fusion None


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