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Annotation rule MF_01934 |
General rule information
[?]
Accession |
MF_01934 |
Dates |
8-OCT-2014 (Created) 19-NOV-2019 (Last updated, Version 7) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=1,4-dihydroxy-2-naphthoyl-CoA synthase;
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Short=DHNA-CoA synthase;
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EC 4.1.3.36;
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Function |
Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA). |
Catalytic activity |
RHEA:26562: 2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
EC 4.1.3.36
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case <FTTag:hydrogencarbonate>
end case
Pathway |
Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7. |
case not <OC:Cyanobacteria>
Pathway |
Quinol/quinone metabolism; menaquinone biosynthesis. |
else case <OC:Cyanobacteria>
Pathway |
Cofactor biosynthesis; phylloquinone biosynthesis. |
end case
Similarity |
Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. |
case not <OC:Cyanobacteria>
end case
GO:0008935; Molecular function: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity.
case not <OC:Cyanobacteria>
GO:0009234; Biological process: menaquinone biosynthetic process.
else case <OC:Cyanobacteria>
GO:0042372; Biological process: phylloquinone biosynthetic process.
end case
From: MENB_ECOLI (P0ABU0) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION (Optional)
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84
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88
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Substrate binding
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[SAVT]-G-G-[DN]-Q
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REGION (Optional)
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129
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133
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Substrate binding
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[YWF]-[SAT]-x-G-G
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REGION (Optional)
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154
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156
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Hydrogencarbonate binding
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hydrogencarbonate
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Q-T-G
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BINDING (Optional)
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45
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45
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Substrate
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R
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BINDING (Optional)
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97
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97
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Substrate
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Y
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BINDING (Optional)
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155
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155
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Substrate
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T
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BINDING (Optional)
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161
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161
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Substrate
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S
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BINDING (Optional)
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258
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258
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Substrate; shared with neighboring subunit
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Y
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BINDING (Optional)
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273
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273
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Substrate; shared with neighboring subunit
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K
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SITE
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97
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97
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Important for catalysis
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Y
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SITE
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258
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258
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Important for catalysis
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Y
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From: MENB_MYCTU (P9WNP5) |
SITE (Optional)
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185
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185
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Important for catalysis
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D
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Additional information
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Size range |
250-391 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
The hydrogencarbonate anion plays the same catalytic role (proton acceptor) as the side-chain carboxylate group of the essential 'Asp-185' found in actinobacteria, archaea, bacteroidetes, and deltaproteobacteria. |