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Annotation rule MF_01934
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General rule information [?]

Accession MF_01934
Dates 8-OCT-2014 (Created)
19-NOV-2019 (Last updated, Version 7)
Name MenB
Scope
Bacteria
Archaea
Templates P0ABU0 (MENB_ECOLI); P23966 (MENB_BACSU); A0QRD3 (MENB_MYCS2); P9WNP5 (MENB_MYCTU); Q7CQ56 (MENB_SALTY); Q5HH38 (MENB_STAAC): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MENB
Protein name
RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA synthase;
Short=DHNA-CoA synthase;
EC 4.1.3.36;
Gene name
menB

Comments [?]

Function Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
Catalytic activity RHEA:26562: 2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
EC 4.1.3.36
case <FTTag:hydrogencarbonate>
Cofactor hydrogencarbonate
end case
Pathway Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.
case not <OC:Cyanobacteria>
Pathway Quinol/quinone metabolism; menaquinone biosynthesis.
else case <OC:Cyanobacteria>
Pathway Cofactor biosynthesis; phylloquinone biosynthesis.
end case
Similarity Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.

Keywords [?]

Lyase
case not <OC:Cyanobacteria>
Menaquinone biosynthesis
end case

Gene Ontology [?]

GO:0008935; Molecular function: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity.
case not <OC:Cyanobacteria>
GO:0009234; Biological process: menaquinone biosynthetic process.
else case <OC:Cyanobacteria>
GO:0042372; Biological process: phylloquinone biosynthetic process.
end case

Cross-references [?]

PROSITE PS00166; ENOYL_COA_HYDRATASE; 1;
Pfam PF00378; ECH; 1;
TIGRFAMs TIGR01929; menB; 1;

Features [?]

From: MENB_ECOLI (P0ABU0)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     84     88       Substrate binding     [SAVT]-G-G-[DN]-Q  
REGION (Optional)     129     133       Substrate binding     [YWF]-[SAT]-x-G-G  
REGION (Optional)     154     156       Hydrogencarbonate binding   hydrogencarbonate   Q-T-G  
BINDING (Optional)     45     45       Substrate     R  
BINDING (Optional)     97     97       Substrate     Y  
BINDING (Optional)     155     155       Substrate     T  
BINDING (Optional)     161     161       Substrate     S  
BINDING (Optional)     258     258       Substrate; shared with neighboring subunit     Y  
BINDING (Optional)     273     273       Substrate; shared with neighboring subunit     K  
SITE     97     97       Important for catalysis     Y  
SITE     258     258       Important for catalysis     Y  
From: MENB_MYCTU (P9WNP5)
SITE (Optional)     185     185       Important for catalysis     D  

Additional information [?]

Size range 250-391 amino acids
Related rules None
Fusion None
Comments The hydrogencarbonate anion plays the same catalytic role (proton acceptor) as the side-chain carboxylate group of the essential 'Asp-185' found in actinobacteria, archaea, bacteroidetes, and deltaproteobacteria.


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