HAMAP rule MF_01934
General rule information
[?]
| Accession | MF_01934 |
| Dates | 8-OCT-2014 (Created) 1-JUN-2023 (Last updated, Version 13) |
| Name | MenB |
| Scope | Bacteria
Archaea |
| Templates | P0ABU0 (MENB_ECOLI); P23966 (MENB_BACSU); A0QRD3 (MENB_MYCS2); P9WNP5 (MENB_MYCTU); Q7CQ56 (MENB_SALTY); Q5HH38 (MENB_STAAC): [Recover all] |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
| Protein name |
|
||||||||||||
| Gene name |
|
Comments
[?]
| Function | Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA). |
| Catalytic activity | RHEA:26562: 2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
EC 4.1.3.36 |
case <FTTag:hydrogencarbonate>
| Cofactor | hydrogencarbonate |
end case
| Pathway | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7. |
case not <OC:Cyanobacteriota>
| Pathway | Quinol/quinone metabolism; menaquinone biosynthesis. |
else case <OC:Cyanobacteriota>
| Pathway | Cofactor biosynthesis; phylloquinone biosynthesis. |
end case
| Similarity | Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. |
Keywords
[?]
case not <OC:Cyanobacteriota>
end case
Gene Ontology
[?]
GO:0008935; Molecular function: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity.
case not <OC:Cyanobacteriota>
GO:0009234; Biological process: menaquinone biosynthetic process.
else case <OC:Cyanobacteriota>
GO:0042372; Biological process: phylloquinone biosynthetic process.
end case
Cross-references
[?]
Features
[?]
| From: MENB_ECOLI (P0ABU0) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 84 | 88 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | [SAVT]-G-G-[DN]-Q | ||||||||
| BINDING | 129 | 133 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | |||||||||
| BINDING (Optional) | 154 | 156 | /ligand="hydrogencarbonate" /ligand_id="ChEBI:CHEBI:17544 | hydrogencarbonate | Q-T-G | |||||||
| BINDING (Optional) | 45 | 45 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | R | ||||||||
| BINDING (Optional) | 97 | 97 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | Y | ||||||||
| BINDING (Optional) | 155 | 155 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | T | ||||||||
| BINDING (Optional) | 161 | 161 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits" /note="in other chain | S | ||||||||
| BINDING (Optional) | 258 | 258 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits | Y | ||||||||
| BINDING (Optional) | 273 | 273 | /ligand="substrate" /ligand_note="ligand shared between two neighboring subunits | K | ||||||||
| SITE | 97 | 97 | Important for catalysis | Y | ||||||||
| SITE | 258 | 258 | Important for catalysis | Y | ||||||||
| From: MENB_MYCTU (P9WNP5) | ||||||||||||
| SITE (Optional) | 185 | 185 | Important for catalysis | D | ||||||||
Additional information
[?]
| Size range | 250-391 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | The hydrogencarbonate anion plays the same catalytic role (proton acceptor) as the side-chain carboxylate group of the essential 'Asp-185' found in actinobacteria, archaea, bacteroidetes, and deltaproteobacteria. |