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HAMAP rule MF_01936

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General rule information [?]

Accession MF_01936
Dates 23-OCT-2014 (Created)
1-JUN-2023 (Last updated, Version 7)
Name MenI
Bacteria; Enterobacterales
Template P77781 (MENI_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase;
Short=DHNA-CoA hydrolase;
AltName: Full=DHNA-CoA thioesterase;
Gene name

Comments [?]

Function Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).
Catalytic activity RHEA:26309: 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)
Pathway Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.
Quinol/quinone metabolism; menaquinone biosynthesis.
Subunit Homotetramer. Dimer of dimers.
Similarity Belongs to the thioesterase PaaI family.

Keywords [?]

Gene Ontology [?]

GO:0016790; Molecular function: thiolester hydrolase activity.
GO:0009234; Biological process: menaquinone biosynthetic process.

Cross-references [?]

Pfam PF03061; 4HBT; 1;
NCBIfam TIGR00369; unchar_dom_1; 1;

Features [?]

From: MENI_ECOLI (P77781)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     89     92       /ligand="substrate     H-[VIL]-[RK]-[SA]  
BINDING (Optional)     106     111       /ligand="substrate     H-[VL]-G-[SAT]-R-H  
ACT_SITE     63     63       Nucleophile or proton acceptor     E  
BINDING (Optional)     82     82       /ligand="substrate     G  

Additional information [?]

Size range 130-160 amino acids
Related rules None
Fusion None
Comments The profile and the rule are currently restricted to Enterobacterales. Further characterization is needed for other species.