HAMAP rule MF_01936

General rule information [?]

Accession	MF_01936
Dates	23-OCT-2014 (Created) 1-JUN-2023 (Last updated, Version 7)

Name

MenI

Scope

Bacteria; Enterobacterales

Template

P77781 (MENI_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MENI

Protein name

RecName:		Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase;
		Short=DHNA-CoA hydrolase;
		EC 3.1.2.28;
AltName:		Full=DHNA-CoA thioesterase;

Gene name

menI

Comments [?]

Function	Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).
Catalytic activity	RHEA:26309: 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+) EC 3.1.2.28
Pathway	Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.
	Quinol/quinone metabolism; menaquinone biosynthesis.
Subunit	Homotetramer. Dimer of dimers.
Similarity	Belongs to the thioesterase PaaI family.

Keywords [?]

Gene Ontology [?]

GO:0016790; Molecular function: thiolester hydrolase activity.
GO:0009234; Biological process: menaquinone biosynthetic process.

Cross-references [?]

Pfam	PF03061; 4HBT; 1;
NCBIfam	TIGR00369; unchar_dom_1; 1;

Features [?]

From: MENI_ECOLI (P77781)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 89 92 /ligand="substrate H-[VIL]-[RK]-[SA]

BINDING (Optional) 106 111 /ligand="substrate H-[VL]-G-[SAT]-R-H

ACT_SITE 63 63 Nucleophile or proton acceptor E

BINDING (Optional) 82 82 /ligand="substrate G

Additional information [?]

Size range	130-160 amino acids
Related rules	None
Fusion	None
Comments	The profile and the rule are currently restricted to Enterobacterales. Further characterization is needed for other species.