HAMAP rule MF_01936

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01936
Accession	MF_01936
Dates	23-OCT-2014 (Created) 01-JUN-2023 (Last updated, Version 8)
Name	MenI
Scope(s)	Bacteria Enterobacterales
Template(s)	P77781; [ Recover all ]
Triggered by	HAMAP; MF_01936 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MENI
Protein name	RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase; Short=DHNA-CoA hydrolase; EC=3.1.2.28; AltName: Full=DHNA-CoA thioesterase;
Gene name	Name=menI;

Comments [?]

FUNCTION	Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).
CATALYTIC ACTIVITY	Reaction=1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2- naphthoate + CoA + H(+); Xref=Rhea:RHEA:26309, ChEBI:CHEBI:11173, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58897; EC=3.1.2.28;
PATHWAY	Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.
PATHWAY	Quinol/quinone metabolism; menaquinone biosynthesis.
SUBUNIT	Homotetramer. Dimer of dimers.
SIMILARITY	Belongs to the thioesterase PaaI family.

Keywords [?]

Gene Ontology [?]

GO:0016790; Molecular function:thiolester hydrolase activity

GO:0009234; Biological process:menaquinone biosynthetic process

Cross-references [?]

Pfam	PF03061; 4HBT; 1;
NCBIfam	TIGR00369; unchar_dom_1; 1;

Features [?]

From: MENI_ECOLI (P77781)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="substrate"

H-[VIL]-[RK]-[SA]

BINDING

106

111

/ligand="substrate"

H-[VL]-G-[SAT]-R-H

ACT_SITE

/note="Nucleophile or proton acceptor"

BINDING

/ligand="substrate"

Additional information [?]

Size range	130-160 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	The profile and the rule are currently restricted to Enterobacterales. Further characterization is needed for other species.