HAMAP rule MF_01936
General rule information
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Accession | MF_01936 |
Dates | 23-OCT-2014 (Created) 1-JUN-2023 (Last updated, Version 7) |
Name | MenI |
Scope | Bacteria; Enterobacterales |
Template | P77781 (MENI_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA). |
Catalytic activity | RHEA:26309: 1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA + H(+)
EC 3.1.2.28 |
Pathway | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7. |
Quinol/quinone metabolism; menaquinone biosynthesis. | |
Subunit | Homotetramer. Dimer of dimers. |
Similarity | Belongs to the thioesterase PaaI family. |
Keywords
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Gene Ontology
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GO:0016790; Molecular function: thiolester hydrolase activity.
GO:0009234; Biological process: menaquinone biosynthetic process.
GO:0009234; Biological process: menaquinone biosynthetic process.
Cross-references
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Features
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From: MENI_ECOLI (P77781) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING (Optional) | 89 | 92 | /ligand="substrate | H-[VIL]-[RK]-[SA] | ||||||||
BINDING (Optional) | 106 | 111 | /ligand="substrate | H-[VL]-G-[SAT]-R-H | ||||||||
ACT_SITE | 63 | 63 | Nucleophile or proton acceptor | E | ||||||||
BINDING (Optional) | 82 | 82 | /ligand="substrate | G |
Additional information
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Size range | 130-160 amino acids |
Related rules | None |
Fusion | None |
Comments | The profile and the rule are currently restricted to Enterobacterales. Further characterization is needed for other species. |