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HAMAP rule MF_01936

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General rule information [?]

Accession MF_01936
Dates 23-OCT-2014 (Created)
1-JUN-2023 (Last updated, Version 7)
Name MenI
Scope(s) Bacteria
Template(s) P77781 (MENI_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01936 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MENI
Protein name RecName: Full=1,4-dihydroxy-2-naphthoyl-CoA hydrolase;
                 Short=DHNA-CoA hydrolase;
AltName: Full=DHNA-CoA thioesterase;
Gene name Name=menI;

Comments [?]

FUNCTIONCatalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).
CATALYTIC ACTIVITY Reaction=1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2- naphthoate + CoA + H(+); Xref=Rhea:RHEA:26309, ChEBI:CHEBI:11173, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:58897; EC=;
PATHWAYQuinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 7/7.
PATHWAYQuinol/quinone metabolism; menaquinone biosynthesis.
SUBUNITHomotetramer. Dimer of dimers.
SIMILARITYBelongs to the thioesterase PaaI family.

Keywords [?]

Gene Ontology [?]

GO:0016790; Molecular function:thiolester hydrolase activity
GO:0009234; Biological process:menaquinone biosynthetic process

Cross-references [?]

Pfam PF03061; 4HBT; 1;
NCBIfam TIGR00369; unchar_dom_1; 1;

Features [?]

From: MENI_ECOLI (P77781)
Key From To Description Tag Condition FTGroup
BINDING 89 92 /ligand="substrate" H-[VIL]-[RK]-[SA]
BINDING 106 111 /ligand="substrate" H-[VL]-G-[SAT]-R-H
ACT_SITE 63 63 /note="Nucleophile or proton acceptor" E
BINDING 82 82 /ligand="substrate" G

Additional information [?]

Size range 130-160 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The profile and the rule are currently restricted to Enterobacterales. Further characterization is needed for other species.

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