HAMAP rule MF_01937

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01937
Accession	MF_01937
Dates	28-OCT-2014 (Created) 03-SEP-2024 (Last updated, Version 8)
Name	MenA_1
Scope(s)	Bacteria Archaea
Template(s)	P32166; [ Recover all ]
Triggered by	HAMAP; MF_01937 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MENA
Protein name	RecName: Full=1,4-dihydroxy-2-naphthoate octaprenyltransferase; Short=DHNA-octaprenyltransferase; EC=2.5.1.74;
Gene name	Name=menA;

Comments [?]

FUNCTION	Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
CATALYTIC ACTIVITY	Reaction=an all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2- naphthoate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate; Xref=Rhea:RHEA:26478, Rhea:RHEA-COMP:9563, Rhea:RHEA-COMP:9564, ChEBI:CHEBI:11173, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33019, ChEBI:CHEBI:55437, ChEBI:CHEBI:58914; EC=2.5.1.74;
PATHWAY	Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the MenA family. Type 1 subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Membrane
Menaquinone biosynthesis
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0046428; Molecular function:1,4-dihydroxy-2-naphthoate polyprenyltransferase activity

GO:0009234; Biological process:menaquinone biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]