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Annotation rule MF_01937
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General rule information [?]

Accession MF_01937
Dates 28-OCT-2014 (Created)
19-NOV-2019 (Last updated, Version 3)
Name MenA_1
Scope
Bacteria; except Cyanobacteria
Archaea
Template P32166 (MENA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MENA
Protein name
RecName: Full=1,4-dihydroxy-2-naphthoate octaprenyltransferase;
Short=DHNA-octaprenyltransferase;
EC 2.5.1.74;
Gene name
menA

Comments [?]

Function Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
Catalytic activity RHEA:26478: 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate
EC 2.5.1.74
Pathway Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the MenA family. Type 1 subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0046428; Molecular function: 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity.
GO:0009234; Biological process: menaquinone biosynthetic process.
GO:0005887; Cellular component: integral component of plasma membrane.

Cross-references [?]

Pfam PF01040; UbiA; 1;
TIGRFAMs TIGR00751; menA; 1;
PIRSF PIRSF005355; UBIAD1; 1;

Computed features [?]

General Transmembrane; -; 6-9; trigger=yes;

Additional information [?]

Size range 275-360 amino acids
Related rules None
Fusion None