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HAMAP rule MF_01937

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General rule information [?]

Accession MF_01937
Dates 28-OCT-2014 (Created)
1-JUN-2023 (Last updated, Version 6)
Name MenA_1
Scope(s) Bacteria
Template(s) P32166 (MENA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01937 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MENA
Protein name RecName: Full=1,4-dihydroxy-2-naphthoate octaprenyltransferase;
Gene name Name=menA;

Comments [?]

FUNCTIONConversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
CATALYTIC ACTIVITY Reaction=1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate; Xref=Rhea:RHEA:26478, Rhea:RHEA-COMP:9563, Rhea:RHEA-COMP:9564, ChEBI:CHEBI:11173, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33019, ChEBI:CHEBI:55437, ChEBI:CHEBI:58914; EC=;
PATHWAYQuinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 1/2.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the MenA family. Type 1 subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Menaquinone biosynthesis
Transmembrane helix

Gene Ontology [?]

GO:0046428; Molecular function:1,4-dihydroxy-2-naphthoate octaprenyltransferase activity
GO:0009234; Biological process:menaquinone biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01040; UbiA; 1;
NCBIfam TIGR00751; menA; 1;
General Transmembrane; -; 6-9;

Features [?]

Additional information [?]

Size range 275-360 amino acids
Related rules None
Fusion Nter: None Cter: None

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