HAMAP rule MF_01938

General rule information [?]

Accession	MF_01938
Dates	28-OCT-2014 (Created) 17-FEB-2023 (Last updated, Version 6)

Name

MenA_2

Scope

Bacteria; Cyanobacteriota

Template

P73962 (MENA_SYNY3)

Triggered by

HAMAP; MF_01938 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MENA

Protein name

RecName:		Full=2-carboxy-1,4-naphthoquinone phytyltransferase;
		EC 2.5.1.130;
AltName:		Full=1,4-dihydroxy-2-naphthoate phytyltransferase;
		Short=DHNA phytyltransferase;

Gene name

menA

Comments [?]

Function	Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4-naphthoquinone.
Catalytic activity	RHEA:47740: 1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate EC 2.5.1.130
Pathway	Cofactor biosynthesis; phylloquinone biosynthesis.
Subcellular location	Cell inner membrane; Multi-pass membrane protein.
Similarity	Belongs to the MenA family. Type 2 subfamily.

Keywords [?]

Cell inner membrane
Cell membrane
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0042372; Biological process: phylloquinone biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF01040; UbiA; 1;
TIGRFAMs	TIGR02235; menA_cyano-plnt; 1;
PIRSF	PIRSF005355; UBIAD1; 1;

Computed features [?]

General

Transmembrane; -; 7-9; trigger=yes;

Additional information [?]

Size range	277-340 amino acids
Related rules	None
Fusion	None

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