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HAMAP rule MF_01938

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General rule information [?]

Accession MF_01938
Dates 28-OCT-2014 (Created)
1-JUN-2023 (Last updated, Version 7)
Name MenA_2
Scope(s) Bacteria
Template(s) P73962 (MENA_SYNY3); [ Recover all ]
Triggered by HAMAP; MF_01938 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MENA
Protein name RecName: Full=2-carboxy-1,4-naphthoquinone phytyltransferase;
AltName: Full=1,4-dihydroxy-2-naphthoate phytyltransferase;
                 Short=DHNA phytyltransferase;
Gene name Name=menA;

Comments [?]

FUNCTIONInvolved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone.
CATALYTIC ACTIVITY Reaction=1,4-dioxo-2-naphthoate + H(+) + phytyl diphosphate = CO2 + demethylphylloquinone + diphosphate; Xref=Rhea:RHEA:47740, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:31087, ChEBI:CHEBI:33019, ChEBI:CHEBI:75434, ChEBI:CHEBI:87842; EC=;
PATHWAYCofactor biosynthesis; phylloquinone biosynthesis.
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the MenA family. Type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0042372; Biological process:phylloquinone biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01040; UbiA; 1;
NCBIfam TIGR02235; menA_cyano-plnt; 1;
General Transmembrane; -; 7-9;

Features [?]

Additional information [?]

Size range 277-340 amino acids
Related rules None
Fusion Nter: None Cter: None

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