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HAMAP rule MF_01940

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General rule information [?]

Accession MF_01940
Dates 28-NOV-2014 (Created)
1-JUN-2023 (Last updated, Version 6)
Name RNA_CPDase
Scope(s) Bacteria
Template(s) P37025 (THPR_ECOLI); Q8U4Q3 (THPR_PYRFU); Q5SHB1 (THPR_THET8); [ Recover all ]
Triggered by HAMAP; MF_01940 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier THPR
Protein name RecName: Full=RNA 2',3'-cyclic phosphodiesterase;
                 Short=RNA 2',3'-CPDase;
case <OC:Escherichia> or <OC:Shigella>
Gene name Name=thpR;
end case

Comments [?]

FUNCTIONHydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester.
CATALYTIC ACTIVITY Reaction=a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'- end 2'-phospho-ribonucleotide-RNA + H(+); Xref=Rhea:RHEA:11828, Rhea:RHEA-COMP:10464, Rhea:RHEA-COMP:17353, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:83064, ChEBI:CHEBI:173113; EC=;
SIMILARITYBelongs to the 2H phosphoesterase superfamily. ThpR family.

Keywords [?]

Gene Ontology [?]

GO:0008081; Molecular function:phosphoric diester hydrolase activity

Cross-references [?]

Pfam PF02834; LigT_PEase; 2;
NCBIfam TIGR02258; 2_5_ligase; 1;

Features [?]

From: THPR_ECOLI (P37025)
Key From To Description Tag Condition FTGroup
MOTIF 43 46 /note="HXTX 1" H-x-T-x
MOTIF 125 128 /note="HXTX 2" H-x-T-x
ACT_SITE 43 43 /note="Proton donor" H
ACT_SITE 125 125 /note="Proton acceptor" H

Additional information [?]

Size range 153-320 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Was originally thought to be a 2',5'-RNA ligase.

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