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Annotation rule MF_01940
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General rule information [?]

Accession MF_01940
Dates 28-NOV-2014 (Created)
19-NOV-2019 (Last updated, Version 4)
Name RNA_CPDase
Scope
Bacteria
Archaea
Templates P37025 (THPR_ECOLI); Q8U4Q3 (THPR_PYRFU); Q5SHB1 (THPR_THET8): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
THPR
Protein name
RecName: Full=RNA 2',3'-cyclic phosphodiesterase;
Short=RNA 2',3'-CPDase;
EC 3.1.4.58;
case <OC:Escherichia> or <OC:Shigella>
Gene name
thpR
end case

Comments [?]

Function Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.
Catalytic activity RHEA:11828: H2O + RNA(n)-2',3'-cyclic phosphate = H(+) + RNA(n)-2'- phosphate
EC 3.1.4.58
Similarity Belongs to the 2H phosphoesterase superfamily. ThpR family.

Keywords [?]


Gene Ontology [?]

GO:0008081; Molecular function: phosphoric diester hydrolase activity.

Cross-references [?]

Pfam PF02834; LigT_PEase; 2;
TIGRFAMs TIGR02258; 2_5_ligase; 1;

Features [?]

From: THPR_ECOLI (P37025)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     43     46       HXTX 1     H-x-T-x  
MOTIF     125     128       HXTX 2     H-x-T-x  
ACT_SITE     43     43       Proton donor     H  
ACT_SITE     125     125       Proton acceptor     H  

Additional information [?]

Size range 153-320 amino acids
Related rules None
Fusion None
Comments Was originally thought to be a 2',5'-RNA ligase.