HAMAP rule MF_01940
General rule information
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| Accession | MF_01940 |
| Dates | 28-NOV-2014 (Created) 1-JUN-2023 (Last updated, Version 6) |
| Name | RNA_CPDase |
| Scope | Bacteria
Archaea |
| Templates | P37025 (THPR_ECOLI); Q8U4Q3 (THPR_PYRFU); Q5SHB1 (THPR_THET8): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
| Protein name |
|
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case <OC:Escherichia> or <OC:Shigella>
| Gene name |
|
end case
Comments
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| Function | Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. |
| Catalytic activity | RHEA:11828: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)
EC 3.1.4.58 |
| Similarity | Belongs to the 2H phosphoesterase superfamily. ThpR family. |
Keywords
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Gene Ontology
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GO:0008081; Molecular function: phosphoric diester hydrolase activity.
Cross-references
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Features
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| From: THPR_ECOLI (P37025) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 43 | 46 | HXTX 1 | H-x-T-x | ||||||||
| MOTIF | 125 | 128 | HXTX 2 | H-x-T-x | ||||||||
| ACT_SITE | 43 | 43 | Proton donor | H | ||||||||
| ACT_SITE | 125 | 125 | Proton acceptor | H | ||||||||
Additional information
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| Size range | 153-320 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Was originally thought to be a 2',5'-RNA ligase. |