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HAMAP rule MF_01944

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General rule information [?]

Accession MF_01944
Dates 16-DEC-2014 (Created)
26-JAN-2023 (Last updated, Version 7)
Name Lipid_A_LpxM
Scope
Bacteria; Pseudomonadota
Template P24205 (LPXM_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LPXM
case <OC:Escherichia>
Protein name
RecName: Full=Lipid A biosynthesis myristoyltransferase;
EC 2.3.1.243;
AltName: Full=Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase;
else
Protein name
RecName: Full=Lipid A biosynthesis acyltransferase;
EC 2.3.1.243;
AltName: Full=Kdo(2)-lauroyl-lipid IV(A) acyltransferase;
end case
Gene name
lpxM

Comments [?]

case <OC:Escherichia>
Function Catalyzes the transfer of myristate from myristoyl-[acyl-carrier-protein] (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A.
Catalytic activity RHEA:28438: alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]
EC 2.3.1.243
else
Function Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-(acyl)-lipid IV(A) to form a Kdo(2)-lipid A.
Catalytic activity RHEA:69400: a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]
EC 2.3.1.243
end case
Pathway Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4.
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Subcellular location Cell inner membrane; Single-pass membrane protein.
Similarity Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.

Keywords [?]

Acyltransferase
Cell inner membrane
Cell membrane
Lipopolysaccharide biosynthesis
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

case <OC:Escherichia>
GO:0019107; Molecular function: myristoyltransferase activity.
else
GO:0016746; Molecular function: acyltransferase activity.
end case
GO:0036104; Biological process: Kdo2-lipid A biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF03279; Lip_A_acyltrans; 1;
TIGRFAMs TIGR02208; lipid_A_msbB; 1;
PIRSF PIRSF026649; MsbB; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Features [?]

From: LPXM_ECOLI (P24205)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     139     144       HXXXXD motif     H-x-x-x-x-[DE]  

Additional information [?]

Size range 290-365 amino acids
Related rules None
Fusion None


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