HAMAP rule MF_01944
General rule information
[?]
Accession | MF_01944 |
Dates | 16-DEC-2014 (Created) 26-JAN-2023 (Last updated, Version 7) |
Name | Lipid_A_LpxM |
Scope | Bacteria; Pseudomonadota |
Template | P24205 (LPXM_ECOLI) |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
case <OC:Escherichia>
Protein name |
|
else
Protein name |
|
end case
Gene name |
|
Comments
[?]
case <OC:Escherichia>
Function | Catalyzes the transfer of myristate from myristoyl-[acyl-carrier-protein] (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. |
Catalytic activity | RHEA:28438: alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]
EC 2.3.1.243 |
else
Function | Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-(acyl)-lipid IV(A) to form a Kdo(2)-lipid A. |
Catalytic activity | RHEA:69400: a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]
EC 2.3.1.243 |
end case
Pathway | Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4. |
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. | |
Subcellular location | Cell inner membrane; Single-pass membrane protein. |
Similarity | Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily. |
Keywords
[?]
Acyltransferase
Cell inner membrane
Cell membrane
Lipopolysaccharide biosynthesis
Membrane
Transferase
Transmembrane
Transmembrane helix
Cell inner membrane
Cell membrane
Lipopolysaccharide biosynthesis
Membrane
Transferase
Transmembrane
Transmembrane helix
Gene Ontology
[?]
case <OC:Escherichia>
GO:0019107; Molecular function: myristoyltransferase activity.
else
GO:0016746; Molecular function: acyltransferase activity.
end case
GO:0036104; Biological process: Kdo2-lipid A biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0005886; Cellular component: plasma membrane.
Cross-references
[?]
Pfam | PF03279; Lip_A_acyltrans; 1; |
TIGRFAMs | TIGR02208; lipid_A_msbB; 1; |
PIRSF | PIRSF026649; MsbB; 1; |
Computed features
[?]
General | Transmembrane; -; 1; trigger=yes; |
Features
[?]
From: LPXM_ECOLI (P24205) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 139 | 144 | HXXXXD motif | H-x-x-x-x-[DE] |
Additional information
[?]
Size range | 290-365 amino acids |
Related rules | None |
Fusion | None |