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HAMAP rule MF_01944

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General rule information [?]

Accession MF_01944
Dates 16-DEC-2014 (Created)
1-JUN-2023 (Last updated, Version 8)
Name Lipid_A_LpxM
Scope(s) Bacteria
Template(s) P24205 (LPXM_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01944 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LPXM
case <OC:Escherichia>
Protein name RecName: Full=Lipid A biosynthesis myristoyltransferase;
AltName: Full=Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase;
Protein name RecName: Full=Lipid A biosynthesis acyltransferase;
AltName: Full=Kdo(2)-lauroyl-lipid IV(A) acyltransferase;
end case
Gene name Name=lpxM;

Comments [?]

case <OC:Escherichia>
FUNCTIONCatalyzes the transfer of myristate from myristoyl-[acyl- carrier-protein] (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A.
CATALYTIC ACTIVITY Reaction=alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]; Xref=Rhea:RHEA:28438, Rhea:RHEA-COMP:9648, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:58540, ChEBI:CHEBI:61524, ChEBI:CHEBI:64479, ChEBI:CHEBI:78477; EC=;
FUNCTIONCatalyzes the transfer of an acyl chain from an acyl-[acyl- carrier-protein] (ACP) to a Kdo(2)-(acyl)-lipid IV(A) to form a Kdo(2)- lipid A.
CATALYTIC ACTIVITY Reaction=a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)- (acyl)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]; Xref=Rhea:RHEA:69400, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:14125, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651, ChEBI:CHEBI:176430, ChEBI:CHEBI:176431; EC=;
end case
PATHWAYGlycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)- lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4.
PATHWAYBacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
SIMILARITYBelongs to the LpxL/LpxM/LpxP family. LpxM subfamily.

Keywords [?]

Gene Ontology [?]

case <OCellular component:Escherichia>
GO:0019107; Molecular function:myristoyltransferase activity
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0016746; Molecular function:acyltransferase activity
end case
GO:0036104; Biological process:Kdo2-lipid A biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF03279; Lip_A_acyltrans; 1;
NCBIfam TIGR02208; lipid_A_msbB; 1;
PIRSF PIRSF026649; MsbB; 1;
General Transmembrane; -; 1;

Features [?]

From: LPXM_ECOLI (P24205)
Key From To Description Tag Condition FTGroup
MOTIF 139 144 /note="HXXXXD motif" H-x-x-x-x-[DE]

Additional information [?]

Size range 290-365 amino acids
Related rules None
Fusion Nter: None Cter: None

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