HAMAP rule MF_01944
General rule information
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| Accession | MF_01944 |
| Dates | 16-DEC-2014 (Created)
1-JUN-2023 (Last updated, Version 8) |
| Name | Lipid_A_LpxM |
| Scope(s) |
Bacteria Pseudomonadota |
| Template(s) | P24205 (LPXM_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01944 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LPXM |
| case <OC:Escherichia> | |
| Protein name | RecName: Full=Lipid A biosynthesis myristoyltransferase; EC=2.3.1.243; AltName: Full=Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase; |
| else | |
| Protein name | RecName: Full=Lipid A biosynthesis acyltransferase; EC=2.3.1.243; AltName: Full=Kdo(2)-lauroyl-lipid IV(A) acyltransferase; |
| end case | |
| Gene name | Name=lpxM; |
Comments
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| case <OC:Escherichia> | |
| FUNCTION | Catalyzes the transfer of myristate from myristoyl-[acyl- carrier-protein] (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A. |
| CATALYTIC ACTIVITY | Reaction=alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(dodecanoyl)-lipid IVA (E. coli) + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + holo-[ACP]; Xref=Rhea:RHEA:28438, Rhea:RHEA-COMP:9648, Rhea:RHEA-COMP:9685, ChEBI:CHEBI:58540, ChEBI:CHEBI:61524, ChEBI:CHEBI:64479, ChEBI:CHEBI:78477; EC=2.3.1.243; |
| else | |
| FUNCTION | Catalyzes the transfer of an acyl chain from an acyl-[acyl- carrier-protein] (ACP) to a Kdo(2)-(acyl)-lipid IV(A) to form a Kdo(2)- lipid A. |
| CATALYTIC ACTIVITY | Reaction=a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)- (acyl)-lipid IVA = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]; Xref=Rhea:RHEA:69400, Rhea:RHEA-COMP:9685, Rhea:RHEA- COMP:14125, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651, ChEBI:CHEBI:176430, ChEBI:CHEBI:176431; EC=2.3.1.243; |
| end case | |
| PATHWAY | Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)- lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4. |
| PATHWAY | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
| SIMILARITY | Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily. |
Keywords
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| Acyltransferase |
| Cell inner membrane |
| Cell membrane |
| Lipopolysaccharide biosynthesis |
| Membrane |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| case <OCellular component:Escherichia> | |
| GO:0019107; Molecular function:myristoyltransferase activity | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0016746; Molecular function:acyltransferase activity | |
| end case | |
| GO:0036104; Biological process:Kdo2-lipid A biosynthetic process | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
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| Pfam | PF03279; Lip_A_acyltrans; 1; |
| NCBIfam | TIGR02208; lipid_A_msbB; 1; |
| PIRSF | PIRSF026649; MsbB; 1; |
| General | Transmembrane; -; 1; |
Features
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| From: LPXM_ECOLI (P24205) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 139 | 144 | /note="HXXXXD motif" | H-x-x-x-x-[DE] | ||||||||
Additional information
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| Size range | 290-365 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |