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Annotation rule MF_01944 |
Accession | MF_01944 |
Dates | 16-DEC-2014 (Created) 19-NOV-2019 (Last updated, Version 4) |
Name | Lipid_A_LpxM |
Scope | Bacteria; Proteobacteria |
Template | P24205 (LPXM_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. |
Catalytic activity | RHEA:28438: dodecanoyl-(Kdo)2-lipid IVA + tetradecanoyl-[ACP] = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]
EC 2.3.1.243 |
Pathway | Glycolipid biosynthesis; KDO(2)-lipid A biosynthesis; KDO(2)-lipid A from CMP-3-deoxy-D-manno-octulosonate and lipid IV(A): step 4/4. |
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. | |
Subcellular location | Cell inner membrane; Single-pass membrane protein. |
Similarity | Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily. |
Pfam | PF03279; Lip_A_acyltrans; 1; |
TIGRFAMs | TIGR02208; lipid_A_msbB; 1; |
PIRSF | PIRSF026649; MsbB; 1; |
General | Transmembrane; -; 1; trigger=yes; |
From: LPXM_ECOLI (P24205) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 139 | 144 | HXXXXD motif | H-x-x-x-x-[DE] |
Size range | 290-365 amino acids |
Related rules | None |
Fusion | None |