HAMAP rule MF_01945
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01945 |
| Accession | MF_01945 |
| Dates | 17-DEC-2014 (Created)
03-SEP-2024 (Last updated, Version 10) |
| Name | Lipid_A_LpxT |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P76445; [ Recover all ] |
| Triggered by |
HAMAP; MF_01945 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LPXT |
| Protein name | RecName: Full=Lipid A 1-diphosphate synthase; EC=2.7.4.29; AltName: Full=Kdo(2)-lipid A phosphotransferase; AltName: Full=Undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase; |
| Gene name | Name=lpxT; |
Comments
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| FUNCTION | Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P). |
| case <OC:Escherichia> | |
| CATALYTIC ACTIVITY | Reaction=di-trans,octa-cis-undecaprenyl diphosphate + alpha-Kdo-(2->4)- alpha-Kdo-(2->6)-lipid A (E. coli) = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate; Xref=Rhea:RHEA:45468, ChEBI:CHEBI:58405, ChEBI:CHEBI:58540, ChEBI:CHEBI:60392, ChEBI:CHEBI:85271; EC=2.7.4.29; |
| else | |
| CATALYTIC ACTIVITY | Reaction=an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa- cis-undecaprenyl diphosphate = an alpha-D-Kdo-(2->4)-alpha-D-Kdo- (2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate; Xref=Rhea:RHEA:74291, ChEBI:CHEBI:58405, ChEBI:CHEBI:60392, ChEBI:CHEBI:176431, ChEBI:CHEBI:193150; EC=2.7.4.29; |
| end case | |
| PATHWAY | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. Note=Transferase activity takes place on the periplamic side of the inner membrane. |
| SIMILARITY | Belongs to the LpxT phosphotransferase family. |
Keywords
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| Cell inner membrane |
| Cell membrane |
| Lipopolysaccharide biosynthesis |
| Membrane |
| Transferase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0016776; Molecular function:phosphotransferase activity, phosphate group as acceptor |
| GO:0009245; Biological process:lipid A biosynthetic process |
| GO:0009103; Biological process:lipopolysaccharide biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF01569; PAP2; 1; |
| General | Transmembrane; -; 5-6; |
Features
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Additional information
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| Size range | 216-262 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |