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HAMAP rule MF_01945

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General rule information [?]

Accession MF_01945
Dates 17-DEC-2014 (Created)
29-SEP-2022 (Last updated, Version 7)
Name Lipid_A_LpxT
Scope
Bacteria; Enterobacterales
Template P76445 (LPXT_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LPXT
Protein name
RecName: Full=Lipid A 1-diphosphate synthase;
EC 2.7.4.29;
AltName: Full=Kdo(2)-lipid A phosphotransferase;
AltName: Full=Undecaprenyl pyrophosphate:lipid A 1-phosphate phosphotransferase;
Gene name
lpxT

Comments [?]

Function Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1-diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P).
case <OC:Escherichia>
Catalytic activity RHEA:45468: alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate
EC 2.7.4.29
else
Catalytic activity RHEA:74291: an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate = an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate
EC 2.7.4.29
end case
Pathway Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Subcellular location Cell inner membrane; Multi-pass membrane protein. Note=Transferase activity takes place on the periplamic side of the inner membrane.
Similarity Belongs to the LpxT phosphotransferase family.

Keywords [?]

Cell inner membrane
Cell membrane
Lipopolysaccharide biosynthesis
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0016776; Molecular function: phosphotransferase activity, phosphate group as acceptor.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01569; PAP2; 1;

Computed features [?]

General Transmembrane; -; 5-6; trigger=yes;

Additional information [?]

Size range 216-262 amino acids
Related rules None
Fusion None


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