HAMAP rule MF_01945
General rule information
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Accession | MF_01945 |
Dates | 17-DEC-2014 (Created) 29-SEP-2022 (Last updated, Version 7) |
Name | Lipid_A_LpxT |
Scope | Bacteria; Enterobacterales |
Template | P76445 (LPXT_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1-diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P). |
case <OC:Escherichia>
Catalytic activity | RHEA:45468: alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl diphosphate = (Kdo)2-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate
EC 2.7.4.29 |
else
Catalytic activity | RHEA:74291: an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate = an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate
EC 2.7.4.29 |
end case
Pathway | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
Subcellular location | Cell inner membrane; Multi-pass membrane protein. Note=Transferase activity takes place on the periplamic side of the inner membrane. |
Similarity | Belongs to the LpxT phosphotransferase family. |
Keywords
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Cell inner membrane
Cell membrane
Lipopolysaccharide biosynthesis
Membrane
Transferase
Transmembrane
Transmembrane helix
Cell membrane
Lipopolysaccharide biosynthesis
Membrane
Transferase
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0016776; Molecular function: phosphotransferase activity, phosphate group as acceptor.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Pfam | PF01569; PAP2; 1; |
Computed features
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General | Transmembrane; -; 5-6; trigger=yes; |
Additional information
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Size range | 216-262 amino acids |
Related rules | None |
Fusion | None |