HAMAP rule MF_01952

General rule information [?]

Accession	MF_01952
Dates	6-APR-2006 (Created) 19-NOV-2022 (Last updated, Version 23)

Name

UlaF

Scope

Bacteria; Enterobacteriaceae

Template

P39306 (ULAF_ECOLI)

Triggered by

HAMAP; MF_01952 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ULAF

case <FTGroup:1>

Protein name

RecName:		Full=L-ribulose-5-phosphate 4-epimerase UlaF;
		EC 5.1.3.4;
AltName:		Full=L-ascorbate utilization protein F;
AltName:		Full=Phosphoribulose isomerase;

end case

case not <FTGroup:1>

Protein name

RecName:

Full=Putative L-ribulose-5-phosphate 4-epimerase;

end case

Gene name

ulaF

Comments [?]

Function	Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization.
Catalytic activity	RHEA:22368: L-ribulose 5-phosphate = D-xylulose 5-phosphate EC 5.1.3.4
Cofactor	Zn(2+) Note: Binds 1 zinc ion per subunit.
Pathway	Cofactor degradation; L-ascorbate degradation; D-xylulose 5-phosphate from L-ascorbate: step 4/4.
Induction	Induced by L-ascorbate. Repressed by UlaR.
Similarity	Belongs to the aldolase class II family. AraD/FucA subfamily.

Keywords [?]

Carbohydrate metabolism
Isomerase
Metal-binding
Zinc

Gene Ontology [?]

GO:0019852; Biological process: L-ascorbic acid metabolic process.
GO:0008742; Molecular function: L-ribulose-phosphate 4-epimerase activity.
GO:0008270; Molecular function: zinc ion binding.

Cross-references [?]

Pfam	PF00596; Aldolase_II; 1;

Features [?]

From: ULAF_ECOLI (P39306)

Key From To Description Tag Condition FTGroup

BINDING 26 27 /ligand="substrate G-N

BINDING 43 44 /ligand="substrate [TS]-G

BINDING 72 73 /ligand="substrate S-S

ACT_SITE 118 118 Proton donor/acceptor D

ACT_SITE 225 225 Proton donor/acceptor Y

BINDING 74 74 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 D 1

BINDING 93 93 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 95 95 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

BINDING 167 167 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105 H 1

Additional information [?]

Size range	228-228 amino acids
Related rules	None
Fusion	None

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