HAMAP rule MF_01956
General rule information
[?]
Accession |
MF_01956 |
Dates |
5-MAY-2006 (Created) 19-NOV-2019 (Last updated, Version 14) |
Scope |
Bacteria; Enterobacterales |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=G/U mismatch-specific DNA glycosylase;
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EC 3.2.2.28;
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AltName:
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Full=Double-strand-specific uracil glycosylase;
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AltName:
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Full=Mismatch-specific uracil DNA-glycosylase;
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Short=MUG;
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Function |
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells. |
Catalytic activity |
Reaction=Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.28; |
Subunit |
Binds DNA as a monomer. |
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family. |
GO:0008263; Molecular function: pyrimidine-specific mismatch base pair DNA N-glycosylase activity.
GO:0006285; Biological process: base-excision repair, AP site formation.
GO:0005737; Cellular component: cytoplasm.
Additional information
[?]
Size range |
162-168 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
In SHIFL, mug (SF3110, S3315) is a pseudogene due to a stop codon in position 118. The sequence has been checked and is believed to be correct |