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| Annotation rule MF_01956 |
General rule information
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| Accession | MF_01956 |
| Dates | 5-MAY-2006 (Created) 19-NOV-2019 (Last updated, Version 14) |
| Name | MUG |
| Scope | Bacteria; Enterobacterales |
| Template | P0A9H1 (MUG_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells. |
| Catalytic activity | Reaction=Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.28; |
| Subunit | Binds DNA as a monomer. |
| Subcellular location | Cytoplasm. |
| Similarity | Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family. |
Keywords
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Gene Ontology
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GO:0008263; Molecular function: pyrimidine-specific mismatch base pair DNA N-glycosylase activity.
GO:0006285; Biological process: base-excision repair, AP site formation.
GO:0005737; Cellular component: cytoplasm.
GO:0006285; Biological process: base-excision repair, AP site formation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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| Pfam | PF03167; UDG; 1; |
Additional information
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| Size range | 162-168 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | In SHIFL, mug (SF3110, S3315) is a pseudogene due to a stop codon in position 118. The sequence has been checked and is believed to be correct |