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HAMAP rule MF_01956

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General rule information [?]

Accession MF_01956
Dates 5-MAY-2006 (Created)
19-NOV-2019 (Last updated, Version 14)
Name MUG
Scope(s) Bacteria
Template(s) P0A9H1 (MUG_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01956 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MUG
Protein name RecName: Full=G/U mismatch-specific DNA glycosylase;
AltName: Full=Double-strand-specific uracil glycosylase;
AltName: Full=Mismatch-specific uracil DNA-glycosylase;
Gene name Name=mug;

Comments [?]

FUNCTIONExcises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.
CATALYTIC ACTIVITY Reaction=Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=;
SUBUNITBinds DNA as a monomer.
SIMILARITYBelongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.

Keywords [?]

Gene Ontology [?]

GO:0008263; Molecular function:pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0006285; Biological process:base-excision repair, AP site formation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF03167; UDG; 1;

Features [?]

Additional information [?]

Size range 162-168 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments In SHIFL, mug (SF3110, S3315) is a pseudogene due to a stop codon in position 118. The sequence has been checked and is believed to be correct

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