HAMAP rule MF_01956

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01956
Accession	MF_01956
Dates	05-MAY-2006 (Created) 19-NOV-2019 (Last updated, Version 15)
Name	MUG
Scope(s)	Bacteria Enterobacterales
Template(s)	P0A9H1; [ Recover all ]
Triggered by	HAMAP; MF_01956 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MUG
Protein name	RecName: Full=G/U mismatch-specific DNA glycosylase; EC=3.2.2.28; AltName: Full=Double-strand-specific uracil glycosylase; AltName: Full=Mismatch-specific uracil DNA-glycosylase; Short=MUG;
Gene name	Name=mug;

Comments [?]

FUNCTION	Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.
CATALYTIC ACTIVITY	Reaction=Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.28;
SUBUNIT	Binds DNA as a monomer.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.

Keywords [?]

Gene Ontology [?]

GO:0008263; Molecular function:pyrimidine-specific mismatch base pair DNA N-glycosylase activity

GO:0006285; Biological process:base-excision repair, AP site formation

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF03167; UDG; 1;

Features [?]

Additional information [?]

Size range	162-168 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	In SHIFL, mug (SF3110, S3315) is a pseudogene due to a stop codon in position 118. The sequence has been checked and is believed to be correct