HAMAP rule MF_01956

General rule information [?]

Accession	MF_01956
Dates	5-MAY-2006 (Created) 19-NOV-2019 (Last updated, Version 14)

Name

MUG

Scope

Bacteria; Enterobacterales

Template

P0A9H1 (MUG_ECOLI)

Triggered by

HAMAP; MF_01956 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MUG

Protein name

RecName:		Full=G/U mismatch-specific DNA glycosylase;
		EC 3.2.2.28;
AltName:		Full=Double-strand-specific uracil glycosylase;
AltName:		Full=Mismatch-specific uracil DNA-glycosylase;
		Short=MUG;

Gene name

mug

Comments [?]

Function	Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.
Catalytic activity	Reaction=Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.28;
Subunit	Binds DNA as a monomer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.

Keywords [?]

Cytoplasm
DNA damage
DNA excision
DNA repair
DNA-binding
Hydrolase

Gene Ontology [?]

GO:0008263; Molecular function: pyrimidine-specific mismatch base pair DNA N-glycosylase activity.
GO:0006285; Biological process: base-excision repair, AP site formation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF03167; UDG; 1;

Additional information [?]

Size range	162-168 amino acids
Related rules	None
Fusion	None
Comments	In SHIFL, mug (SF3110, S3315) is a pseudogene due to a stop codon in position 118. The sequence has been checked and is believed to be correct

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