HAMAP rule MF_01956
General rule information
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| Accession | MF_01956 |
| Dates | 5-MAY-2006 (Created)
19-NOV-2019 (Last updated, Version 14) |
| Name | MUG |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0A9H1 (MUG_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01956 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MUG |
| Protein name | RecName: Full=G/U mismatch-specific DNA glycosylase; EC=3.2.2.28; AltName: Full=Double-strand-specific uracil glycosylase; AltName: Full=Mismatch-specific uracil DNA-glycosylase; Short=MUG; |
| Gene name | Name=mug; |
Comments
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| FUNCTION | Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells. |
| CATALYTIC ACTIVITY | Reaction=Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.28; |
| SUBUNIT | Binds DNA as a monomer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family. |
Keywords
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Gene Ontology
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| GO:0008263; Molecular function:pyrimidine-specific mismatch base pair DNA N-glycosylase activity |
| GO:0006285; Biological process:base-excision repair, AP site formation |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF03167; UDG; 1; |
Features
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Additional information
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| Size range | 162-168 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | In SHIFL, mug (SF3110, S3315) is a pseudogene due to a stop codon in position 118. The sequence has been checked and is believed to be correct |