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Annotation rule MF_01956 |
Accession | MF_01956 |
Dates | 5-MAY-2006 (Created) 19-NOV-2019 (Last updated, Version 14) |
Name | MUG |
Scope | Bacteria; Enterobacterales |
Template | P0A9H1 (MUG_ECOLI) |
Triggered by |
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Function | Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells. |
Catalytic activity | Reaction=Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.28; |
Subunit | Binds DNA as a monomer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family. |
Pfam | PF03167; UDG; 1; |
Size range | 162-168 amino acids |
Related rules | None |
Fusion | None |
Comments | In SHIFL, mug (SF3110, S3315) is a pseudogene due to a stop codon in position 118. The sequence has been checked and is believed to be correct |