Home  |  Contact
Annotation rule MF_01961
Send feedback

General rule information [?]

Accession MF_01961
Dates 23-OCT-2008 (Created)
19-NOV-2019 (Last updated, Version 24)
Name Catal_peroxid
Scope
Bacteria
Archaea; Euryarchaeota
Templates P13029 (KATG_ECOLI); O59651 (KATG2_HALMA); Q939D2 (KATG_BURPS); P9WIE5 (KATG_MYCTU); Q31MN3 (KATG_SYNE7): [Recover all]
case <OC:Bacteria> or <OC:Archaea>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KATG
Protein name
RecName: Full=Catalase-peroxidase;
Short=CP;
EC 1.11.1.21;
AltName: Full=Peroxidase/catalase;
Gene name
katG

Comments [?]

Function Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
Catalytic activity RHEA:30275: AH2 + H2O2 = A + 2 H2O
EC 1.11.1.21
RHEA:20309: 2 H2O2 = 2 H2O + O2
EC 1.11.1.21
Cofactor heme b
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
Subunit Homodimer or homotetramer.
Ptm Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
Similarity Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Keywords [?]

Heme
Hydrogen peroxide
Iron
Metal-binding
Oxidoreductase
Peroxidase

Gene Ontology [?]

GO:0004096; Molecular function: catalase activity.
GO:0004601; Molecular function: peroxidase activity.

Cross-references [?]

PROSITE PS00435; PEROXIDASE_1; 1;
PS00436; PEROXIDASE_2; 1;
PS50873; PEROXIDASE_4; 1;
Pfam PF00141; peroxidase; 2;
PRINTS PR00460; BPEROXIDASE; 1;
PR00458; PEROXIDASE; 1;
TIGRFAMs TIGR00198; Cat_per_HPI; 1;

Computed features [?]

General Signal; -; 0-1; trigger=yes;

Features [?]

From: KATG_ECOLI (P13029)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     106     106       Proton acceptor     H  
METAL     267     267       Iron (heme axial ligand)     H  
SITE     102     102       Transition state stabilizer     R  
CROSSLNK     105     226       Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with #{Met-252})     W-x*-Y  
CROSSLNK     226     252       Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with #{Trp-105})     Y-x*-M  

Additional information [?]

Size range 699-781 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)